MyMpn Project

Gene holA (MPN450)

Name	holA
Stable ID	MPN450
Location	548690 - 549634 -
Sequence	1 ATGGGCTGTG GGGCTTGTTG TATACTGTGG GTACAGTCTT TTACTATGAC CGTAGTTTAT 61 GGTGCCGATA TTGGGTTAAT TCACCAGCAG TTAAACCAAC TGCTCAACCC AGCCGCTTGT 121 AAACAGGTCT GGTTTCAAGA TGTTAATAAG CTGTATGATG TGGTGTTAAA CCAGAATCTG 181 TTTGCTGAGG ACACTAAACC GATCCTCATT CACAACTGCA GTTTTTTGGA AAAGAACAAC 241 TTAACTAAGG CTGAATTACA CTGCTTAAAA ACACTTAAAG ATACTGATGT GGTGGTCACC 301 ATTTACAGCG ACAGTCCCGC TAATGCCCTC ATTAATGACC GGGCAATTAC CAAGTATGCT 361 TGTAAACCAG TCACAGCTAA AACCATCCAC CAGGTGATCA GTAAGGCCGC TAAGACACTC 421 AAACTCAACT TAAACCCTGA TTTAATTGAC CACTTAGCCA CGATTCTACC CTTTAACTTA 481 GGGGTCATTG AACAGGAGTT GCGTAAGTTA ACTCTACTTA GCCCGGCAGA ATTACAGGAC 541 AAAAAAATGT TAGAAGCCGT TTTGTGTGAT TACCAAACCA GTCAAATCTT ACAATTAACT 601 GACGCCATGG TGCGTTTGCA AACAGCTAAA GCCTTAAAGT TGATTGAACG CTTGTTTTTA 661 CCAAAGCAGC TCACACCACC GCAATTCCTA GAATTTTTAG CAAATGAACT ACTTTTGGCC 721 TTGATGGTCA AAGGCGTTAA ACCACAAGCT GTTTTCCAAC TACAGTGAAA TGTCAATCCC 781 TTTCGTTTAA AGGCGATTCA AAGCCAGTAC CGCTTTTGAT CCACCAACCA ATTAACGGCC 841 TTAATTAATG CGATTTGGCA GCTGGATATT AAAATTAAGC GCAATGATGG CTTAGCAATC 901 CATTTGCTAA AGCACTTCGT GTTGCGATTC TTTGCGCAAA AGTAA
Download Sequence
Operon	OP409
Operon location	546400 - 549603

Protein (mpn450)

Name	DNA polymerase III subunit delta (EC 2.7.7.7)
Stable ID	Mpn450
Molecular Weight	34540
Isoelectric Point	9
Localization	Cytoplasm
Comment	The delta subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA
Sequence	MGCGACCILWVQSFTMTVVYGADIGLIHQQLNQLLNPAACKQVWFQDVNKLYDVVLNQNLFAEDTKPILIHNCSFLEKNN LTKAELHCLKTLKDTDVVVTIYSDSPANALINDRAITKYACKPVTAKTIHQVISKAAKTLKLNLNPDLIDHLATILPFNL GVIEQELRKLTLLSPAELQDKKMLEAVLCDYQTSQILQLTDAMVRLQTAKALKLIERLFLPKQLTPPQFLEFLANELLLA LMVKGVKPQAVFQLQWNVNPFRLKAIQSQYRFWSTNQLTALINAIWQLDIKIKRNDGLAIHLLKHFVLRFFAQK

Post translational modifications

No post translational modifications were found

GENE/PROTEIN holA (Domains Overview)

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Domains (InterProScan)

Location (aa)	Name (InterPro ID)	Description	GO terms	Sequence	Evalue
19-172	PF06144 (IPR010372)	DNA polymerase III, delta	Biological Process: <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0006260'>'DNA' == '' ? '': 'DNA'; 'replication' == '' ? '': 'replication'; ('GO' == '' ? '': 'GO';:0006260) Cellular Component: <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0009360'>'DNA' == '' ? '': 'DNA'; 'polymerase' == '' ? '': 'polymerase'; 'III' == '' ? '': 'III'; 'complex' == '' ? '': 'complex'; ('GO' == '' ? '': 'GO';:0009360) Molecular Function: <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0003677'>'DNA' == '' ? '': 'DNA'; 'binding' == '' ? '': 'binding'; ('GO' == '' ? '': 'GO';:0003677) <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0003887'>'DNA' == '' ? '': 'DNA';-'directed' == '' ? '': 'directed'; 'DNA' == '' ? '': 'DNA'; 'polymerase' == '' ? '': 'polymerase'; 'activity' == '' ? '': 'activity'; ('GO' == '' ? '': 'GO';:0003887)		0.0087
50-73	PS50818 (IPR006141)	Intein splice site	Biological Process: <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0016539'>'intein' == '' ? '': 'intein';-'mediated' == '' ? '': 'mediated'; 'protein' == '' ? '': 'protein'; 'splicing' == '' ? '': 'splicing'; ('GO' == '' ? '': 'GO';:0016539)		0
113-193	SSF52540 (n.a.)	NULL			0.000009
128-213	G3DSA:1.10.8.60 (n.a.)	NULL			0.00000000054
194-310	SSF48019 (IPR008921)	DNA polymerase III, clamp loader complex, gamma/de	Biological Process: <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0006260'>'DNA' == '' ? '': 'DNA'; 'replication' == '' ? '': 'replication'; ('GO' == '' ? '': 'GO';:0006260) Molecular Function: <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0003677'>'DNA' == '' ? '': 'DNA'; 'binding' == '' ? '': 'binding'; ('GO' == '' ? '': 'GO';:0003677)		0.000000000011

Protein Homology (BLASTP results)

Protein Start	Protein End	Hit Size	Orthologous	Organism	Orthologous Start	Orthologous End	Evalue	Identity	Score	Alignment
16	312	296	- MG315	Mycoplasma genitalium	1	296	<1e-50	43.771	635

External IDs

COG	COG1466L
EC number	2.7.7.7
Gene ID	877048
GI	13508189
GO	DNA replication, recombination and repair
Home COG	L
InterPro	IPR010372\|DNA polymerase III, delta
InterPro	IPR008921\|DNA polymerase III clamp loader subunit, C-terminal
InterPro	IPR006141\|Protein splicing (intein) site
Old MP number	MP391
Pathway	Division, DNA repair and maintenance, cell defense
PDB homologs	1pzx_A
PDB homologs	1mgp_A
Pfam	PF06144
PID	g1674072
RefSeq	NP_110138.1
Swiss-Prot protein ID	Y450_MYCPN
phylomeDB tree	No orthologous found
UniProt	Q50362

Transcription

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OPERON OP409 (Genomic Overview)

Region:546400-549603

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STRING image

STRING legend

PDB image(s)

PDB 1pzx

PDB 1mgp