MyMpn
The Mycoplasma pneumoniae database
 
e.g Mpn001 or dnaN or polymerase
Gene hemK (MPN362)
Name 
hemK
Stable ID 
MPN362
Location 
431707 - 433068 +
Sequence 
    1  ATGAACTTGT ATGAACTTTT CTTGAACCAA AAGCTGCTGT ATGGCACCGA TCCGCACTTT
   61  AACGGTGTTT TTCTCACCCT ATTAGAAAAG TTTGGTCTGC ACTTTAAGGA TTTAACAGCA
  121  CTGTGAAAGC ACGCTAAAAC AATTACTGAC TTTGACGAAC AGGGAATTGT TAATGCTTTA
  181  AAAGCTTACT TTGTCGATCA ACTACCCTTA CCCTATATTA CCGGGAGTGT TAAGCTAGGT
  241  TCATTAACTT TTAAAACTCA ACCTGGCGTC TTTATTCCTC GTGCCGACAG TTTAGCGCTT
  301  TTAAAGGTAG TCAAAGCACA AAACCTTAAA ACCGCGGTTG ACCTTTGCTG TGGAAGCGGT
  361  ACGTTAGCAA TTGCGCTAAA AAAGCGTTTT CCTCACTTAA ATGTTTATGG TAGTGACCTC
  421  AACCCCCAAG CATTGCAGTT AGCGGCGCAA AATGCCCGTT TGAATATGGT TGAAGTGCAG
  481  TGAATTGAAG CTGATTTTTT AGCTGCTCTA GCACAGGTAA ACACACCTAT TGATCTCATT
  541  ATTACCAATC CACCCTATTT AAACGAAAGT CAGTTAGATC AAACTTTAAA CCACGAACCG
  601  CGCAACAGTT TAGTGGCTGA TGGTAACGGA ATTTTGTTTT ACCAAAAGCT GTATAACTTT
  661  TTATTGGGTA ACCGCCAAGT TAAACAAGTG ATACTGGAGT GCTCACCAAC CCAGAAAAAA
  721  GAGTTTTTAG CCTTATTTAG CATTTTTAAA ACTAGTGAAA TTTACACAAG CCACAAGCAA
  781  TTCATCGGTT TGAGTATTGA CAACACTAAA CTACCAGTCT TAAAAATTGC GCAAACCAAG
  841  CAAATTAAAG CACTGCTAGA CAAGGGGATG ACGGCCATTA TCCCCACCGA CACGCAAATA
  901  GGATTAATGA GTTATTGCCA ACAAGATTTA GACCACATTA AACAACGCGA TCCCAACAAG
  961  CACTACGTCC AGTTTTTAGC ACCTAGTCAA ATTAACCAGT TACCCAAACA ATTACAAAAG
 1021  CTAGCCAAAC TGTTTTGACC AGGTGCTTAC ACCTTTATTG TAGATGGACA GAGCTATCGT
 1081  CTACCCAACA GCCCACAGCT GTTAAAGCTC TTAAAAACGG TTGGTTTAAT TTACTGTACC
 1141  AGTGCTAATC AAGCTAAACA AAAACCATTT GGCAAGTTAA GCGCTTACCA GAACGATCCT
 1201  TACTGAGTGC AGCAGAACTG TTTTATTGTG CAAAACAGCT TTAAAAGTAA TAACGAACCG
 1261  TCCTTAATTT ACAACTTGGA TACGAAGCAA ATTGTTCGTG GTAGTTCAAC CCAATTACAA
 1321  CGTTTCCAAG CGTTACTAGC AAAACACAAA TTAAGACACT AA
Download Sequence
Operon 
OP143
Operon location 
432403 - 433050
Protein (mpn362)
Name 
Protein methyltransferase hemK (EC 2.1.1.-) (Protein-glutamine N-methyltransferase hemK) (Protein-(glutamine-N(5)) MTase hemK)
Stable ID 
Mpn362
Molecular Weight 
49830
Isoelectric Point 
10
Localization 
Cytoplasm
Comment A->t6A (N6-threonylcarbamoyladenosine). TRNA modification position 37
Sequence 
MNLYELFLNQKLLYGTDPHFNGVFLTLLEKFGLHFKDLTALWKHAKTITDFDEQGIVNALKAYFVDQLPLPYITGSVKLG
SLTFKTQPGVFIPRADSLALLKVVKAQNLKTAVDLCCGSGTLAIALKKRFPHLNVYGSDLNPQALQLAAQNARLNMVEVQ
WIEADFLAALAQVNTPIDLIITNPPYLNESQLDQTLNHEPRNSLVADGNGILFYQKLYNFLLGNRQVKQVILECSPTQKK
EFLALFSIFKTSEIYTSHKQFIGLSIDNTKLPVLKIAQTKQIKALLDKGMTAIIPTDTQIGLMSYCQQDLDHIKQRDPNK
HYVQFLAPSQINQLPKQLQKLAKLFWPGAYTFIVDGQSYRLPNSPQLLKLLKTVGLIYCTSANQAKQKPFGKLSAYQNDP
YWVQQNCFIVQNSFKSNNEPSLIYNLDTKQIVRGSSTQLQRFQALLAKHKLRH
Post translational modifications
Modification Modified sequence Relative start Relative end Amino acid
Oxidation mNLYELFLNQK 1 12 M
GENE/PROTEIN hemK (Domains Overview)
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Domains (InterProScan)
Location (aa) Name (InterPro ID) Description GO terms Sequence Evalue
1-211 SSF53335 (n.a.) NULL 7.40001e-38
1-283 TIGR00536 (IPR004556) Modification methylase HemK Biological Process:
<'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0006479'>'protein' == '' ? '': 'protein'; 'amino' == '' ? '': 'amino'; 'acid' == '' ? '': 'acid'; 'methylation' == '' ? '': 'methylation'; ('GO' == '' ? '': 'GO';:0006479)

Molecular Function:
<'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0008276'>'protein' == '' ? '': 'protein'; 'methyltransferase' == '' ? '': 'methyltransferase'; 'activity' == '' ? '': 'activity'; ('GO' == '' ? '': 'GO';:0008276)

1.2e-19
66-222 G3DSA:3.40.50.150 (n.a.) NULL 2.9e-40
82-208 PF05175 (IPR007848) Methyltransferase small Molecular Function:
<'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0008168'>'methyltransferase' == '' ? '': 'methyltransferase'; 'activity' == '' ? '': 'activity'; ('GO' == '' ? '': 'GO';:0008168)

6.8e-17
93-219 PTHR18895 (n.a.) NULL 4.80001e-26
93-219 PTHR18895:SF7 (n.a.) NULL 4.80001e-26
180-186 PS00092 (IPR002052) DNA methylase, N-6 adenine-specific, conserved sit Biological Process:
<'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0032259'>'methylation' == '' ? '': 'methylation'; ('GO' == '' ? '': 'GO';:0032259)

Molecular Function:
<'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0003676'>'nucleic' == '' ? '': 'nucleic'; 'acid' == '' ? '': 'acid'; 'binding' == '' ? '': 'binding'; ('GO' == '' ? '': 'GO';:0003676) <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0008168'>'methyltransferase' == '' ? '': 'methyltransferase'; 'activity' == '' ? '': 'activity'; ('GO' == '' ? '': 'GO';:0008168)

0
259-450 SSF55821 (IPR017945) DHBP synthase RibB-like alpha/beta domain 1.1e-22
276-437 PS51163 (IPR006070) Sua5/YciO/YrdC, N-terminal 0
278-445 G3DSA:3.90.870.10 (IPR017945) DHBP synthase RibB-like alpha/beta domain 0.000000000000054
285-425 PF01300 (IPR006070) Sua5/YciO/YrdC, N-terminal 0.00017
Protein Homology (BLASTP results)
Protein Start Protein End Hit Size Orthologous Organism Orthologous Start Orthologous End Evalue Identity Score Alignment
345 433 88 - MAG4520 Mycoplasma agalactiae 68 151 0.000000000008 39.1304 151
69 219 150 - MAG7340 Mycoplasma agalactiae 33 189 0.00000000000003 29.2994 173
69 217 148 - MARTH_orf296 Mycoplasma arthritidis 33 182 0.0000001 24.5161 116
293 383 90 - MARTH_orf655 Mycoplasma arthritidis 10 108 0.0000000002 33.3333 140
296 433 137 - MCJ_000330 Mycoplasma conjunctivae 105 253 0.000001 26.6234 106
68 236 168 - MHO_1610 Mycoplasma hominis 32 200 0.0000000008 25.8427 134
293 383 90 - MHO_3870 Mycoplasma hominis 10 108 0.00000001 30.303 124
69 263 194 - Lactococcus lactis subsp. lactis KF147 63 262 0.00000000000003 26.2136 176
66 217 151 - Bacillus subtilis subsp. subtilis 65 228 0.000000002 23.7805 139
66 217 151 - Bacillus subtilis subsp. subtilis 65 228 0.0000000008 24.3902 142
57 211 154 - b1212 Escherichia coli 55 214 0.00000002 25.9259 129
48 224 176 - b2330 Escherichia coli 68 247 0.00000007 26.455 123
67 220 153 - Rv1300 Mycobacterium tuberculosis 65 227 0.0000000000003 25.7669 170
69 217 148 - MCAP_0145 Mycoplasma capricolum subsp. capricolum 67 223 0.0000000004 28.6624 137
1 451 450 - MG259 Mycoplasma genitalium 1 454 <1e-50 50.8811 1213
69 217 148 - MS53_0182 Mycoplasma synoviae 31 182 0.00000000000007 27.0968 169
296 433 137 - MHP7448_0649 Mycoplasma hyopneumoniae 7448 144 286 0.00000002 33.7838 122
69 217 148 - MHP7448_0140 Mycoplasma hyopneumoniae 7448 36 184 0.000000002 27.6316 132
346 433 87 - MMOB3710 Mycoplasma mobile 80 162 0.0000001 31.8182 116
68 217 149 - MMOB1890 Mycoplasma mobile 32 184 0.00000000000002 27.5641 173
69 217 148 - MSC_0151 Mycoplasma mycoides subsp. mycoides SC 67 223 0.0000000004 29.2994 138
69 204 135 - LIC_10266 Leptospira interrogans serovar Copenhage 73 219 0.0000004 25 116
282 448 166 - MYCGA1390 Mycoplasma gallisepticum 14 182 2e-23 35.2941 252
24 236 212 - MYCGA1380 Mycoplasma gallisepticum 25 246 6e-26 27.4775 274
258 449 191 - MYPE670 Mycoplasma penetrans 29 213 0.000000000006 27 154
47 241 194 - MYPE660 Mycoplasma penetrans 57 260 0.000000000000006 28.9855 180
293 398 105 - Mycoplasma pulmonis 10 114 0.000003 31.5789 105
68 243 175 - Mycoplasma pulmonis 32 209 0.0000000002 27.027 141
External IDs
COG 
COG2890J,COG0009J
EC number 
2.1.1.-
Gene ID 
876873
GI 
13508101
GO 
Translation, ribosomal structure and biogenesis
Home COG 
J
InterPro 
IPR004556|Modification methylase HemK
InterPro 
IPR002052|N-6 Adenine-specific DNA methylase
InterPro 
IPR013216|Methyltransferase type 11
InterPro 
IPR006070|SUA5/yciO/yrdC, N-terminal
Old MP number 
MP474
Pathway 
Metabolism
Pathway 
intermediary metabolism
PDB homologs 
1AQI-A
Pfam 
PF08241
Pfam 
PF08242
Pfam 
PF01170
Pfam 
PF09445
Pfam 
PF06325
Pfam 
PF02475
Pfam 
PF05175
PID 
g1674165
RefSeq 
NP_110050.1
Swiss-Prot protein ID 
Y362_MYCPN
phylomeDB tree No orthologous found
UniProt 
P75419
Transcription
IMAGE BROWSERS

OPERON OP143 (Genomic Overview)
Region:432403-433050

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STRING image

STRING of Mpn362STRING legend

PDB image(s)

1AQI

PDB 1AQI
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