MyMpn
The Mycoplasma pneumoniae database
 
e.g Mpn001 or dnaN or polymerase
Gene hprK (MPN223)
Name 
hprK
Stable ID 
MPN223
Location 
274571 - 275509 +
Sequence 
    1  ATGAAAAAGT TATTAGTCAA GGAGTTAATC GAACAATTTC AGGATTGTGT TAACCTCATT
   61  GATGGGCACA CTAACACCAG TAATGTAATT AGAGTACCCG GATTAAAGCG GGTGGTGTTT
  121  GAAATGCTGG GGTTGTTTTC CAGCCAAATT GGCTCGGTAG CCATTTTGGG CAAACGCGAG
  181  TTTGGCTTTT TGAGTCAAAA AACGCTGGTT GAACAACAGC AAATTCTCCA CAACTTACTC
  241  AAACTCAACC CACCAGCGAT TATTTTGACC AAGTCCTTTA CTGACCCCAC GGTACTTTTA
  301  CAGGTTAACC AGACTTATCA GGTACCGATC CTAAAGACCG ATTTCTTTTC CACGGAACTT
  361  TCCTTTACGG TCGAAACCTA CATTAACGAA CAGTTTGCTA CTGTTGCACA AATTCACGGC
  421  GTCTTGCTGG AAGTTTTTGG TGTAGGTGTC TTATTAACTG GTCGCAGTGG CATTGGTAAA
  481  TCAGAGTGTG CCTTAGATCT AATTAACAAG AACCACCTCT TTGTCGGTGA TGATGCGATT
  541  GAAATATACC GTTTGGGTAA TCGCTTGTTT GGTCGCGCGC AGGAAGTAGC GAAAAAGTTT
  601  ATGGAAATCC GTGGTCTTGG TATTATTAAC GTCGAGCGCT TTTACGGATT GCAAATTACT
  661  AAACAGCGCA CCGAAATCCA GTTAATGGTG AACTTACTGA GTTTAGAAAA ACAAACGACC
  721  GTGACCTTTG AGCGTTTAGG TACCGAATTG AAAAAACAAC GTTTACTCGG AGTTGATTTG
  781  AGCTTTTATG AAATTCCGAT TTCCCCCGGG CGGAAGACGA GTGAAATCAT TGAAAGCGCT
  841  GTAATTGATT TTAAACTTAA GCACAGTGGC TATAACTCTG CTTTAGACTT TATTGAAAAC
  901  CAGAAGGCCA TTTTAAAACG TAAAAAAGAT GAATCCTAG
Download Sequence
Operon 
OP93
Operon location 
265662 - 273150
Protein (mpn223)
Name 
HPr kinase/phosphorylase (HPrK/P) (EC 2.7.11.-) (EC 2.7.4.-) (HPr(Ser) kinase/phosphorylase)
Stable ID 
Mpn223
Molecular Weight 
34320
Isoelectric Point 
9
Localization 
Cytoplasm
Comment Kinase (ATP + HPr = ADP + P-Ser-HPr), and phosphorylase activity (P-Ser-HPr + phosphate = HPr + diphosphate). Serine-47of Hpr (Mpn053). Contrary to HPrK/P of B. subtilis and other bacteria, that of M. pneumoniae is active as a kinase at very low ATP concentrations in the absence of fructose 1,6-bisphosphate (FBP). Kinase activity is slightly activated by FBP, and inhibited by inorganic phosphate (Pi), but FBP prevents kinase inhibition by Pi. Dephosphorylation of P-Ser-HPr by M. pneumoniae HPrK/P is strictly dependent on the presence of Pi, and is inhibited by FBP
Sequence 
MKKLLVKELIEQFQDCVNLIDGHTNTSNVIRVPGLKRVVFEMLGLFSSQIGSVAILGKREFGFLSQKTLVEQQQILHNLL
KLNPPAIILTKSFTDPTVLLQVNQTYQVPILKTDFFSTELSFTVETYINEQFATVAQIHGVLLEVFGVGVLLTGRSGIGK
SECALDLINKNHLFVGDDAIEIYRLGNRLFGRAQEVAKKFMEIRGLGIINVERFYGLQITKQRTEIQLMVNLLSLEKQTT
VTFERLGTELKKQRLLGVDLSFYEIPISPGRKTSEIIESAVIDFKLKHSGYNSALDFIENQKAILKRKKDES
Post translational modifications
No post translational modifications were found
GENE/PROTEIN hprK (Domains Overview)
Click on the features to jump to domain info

 ExportIMG
Domains (InterProScan)
Location (aa) Name (InterPro ID) Description GO terms Sequence Evalue
1-132 SSF75138 (n.a.) NULL 6.39999e-32
1-133 G3DSA:3.40.1390.20 (n.a.) NULL 1.9e-30
1-306 TIGR00679 (IPR003755) Signal transduction serine kinase/phosphorylase, H Biological Process:
<'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0000160'>'two' == '' ? '': 'two';-'component' == '' ? '': 'component'; 'signal' == '' ? '': 'signal'; 'transduction' == '' ? '': 'transduction'; 'system' == '' ? '': 'system'; ('phosphorelay' == '' ? '': 'phosphorelay';) ('GO' == '' ? '': 'GO';:0000160) <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0006109'>'regulation' == '' ? '': 'regulation'; 'of' == '' ? '': 'of'; 'carbohydrate' == '' ? '': 'carbohydrate'; 'metabolic' == '' ? '': 'metabolic'; 'process' == '' ? '': 'process'; ('GO' == '' ? '': 'GO';:0006109)

Molecular Function:
<'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0000155'>'two' == '' ? '': 'two';-'component' == '' ? '': 'component'; 'sensor' == '' ? '': 'sensor'; 'activity' == '' ? '': 'activity'; ('GO' == '' ? '': 'GO';:0000155) <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0004672'>'protein' == '' ? '': 'protein'; 'kinase' == '' ? '': 'kinase'; 'activity' == '' ? '': 'activity'; ('GO' == '' ? '': 'GO';:0004672) <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0005524'>'ATP' == '' ? '': 'ATP'; 'binding' == '' ? '': 'binding'; ('GO' == '' ? '': 'GO';:0005524)

0
2-129 PF02603 (IPR011126) Signal transduction serine kinase/phosphorylase, H Biological Process:
<'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0000160'>'two' == '' ? '': 'two';-'component' == '' ? '': 'component'; 'signal' == '' ? '': 'signal'; 'transduction' == '' ? '': 'transduction'; 'system' == '' ? '': 'system'; ('phosphorelay' == '' ? '': 'phosphorelay';) ('GO' == '' ? '': 'GO';:0000160) <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0006109'>'regulation' == '' ? '': 'regulation'; 'of' == '' ? '': 'of'; 'carbohydrate' == '' ? '': 'carbohydrate'; 'metabolic' == '' ? '': 'metabolic'; 'process' == '' ? '': 'process'; ('GO' == '' ? '': 'GO';:0006109)

Molecular Function:
<'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0000155'>'two' == '' ? '': 'two';-'component' == '' ? '': 'component'; 'sensor' == '' ? '': 'sensor'; 'activity' == '' ? '': 'activity'; ('GO' == '' ? '': 'GO';:0000155) <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0004672'>'protein' == '' ? '': 'protein'; 'kinase' == '' ? '': 'kinase'; 'activity' == '' ? '': 'activity'; ('GO' == '' ? '': 'GO';:0004672) <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0005524'>'ATP' == '' ? '': 'ATP'; 'binding' == '' ? '': 'binding'; ('GO' == '' ? '': 'GO';:0005524)

3.2e-25
130-300 PF07475 (IPR011104) Signal transduction serine kinase/phosphorylase, H Biological Process:
<'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0000160'>'two' == '' ? '': 'two';-'component' == '' ? '': 'component'; 'signal' == '' ? '': 'signal'; 'transduction' == '' ? '': 'transduction'; 'system' == '' ? '': 'system'; ('phosphorelay' == '' ? '': 'phosphorelay';) ('GO' == '' ? '': 'GO';:0000160) <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0006109'>'regulation' == '' ? '': 'regulation'; 'of' == '' ? '': 'of'; 'carbohydrate' == '' ? '': 'carbohydrate'; 'metabolic' == '' ? '': 'metabolic'; 'process' == '' ? '': 'process'; ('GO' == '' ? '': 'GO';:0006109)

Molecular Function:
<'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0000155'>'two' == '' ? '': 'two';-'component' == '' ? '': 'component'; 'sensor' == '' ? '': 'sensor'; 'activity' == '' ? '': 'activity'; ('GO' == '' ? '': 'GO';:0000155) <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0004672'>'protein' == '' ? '': 'protein'; 'kinase' == '' ? '': 'kinase'; 'activity' == '' ? '': 'activity'; ('GO' == '' ? '': 'GO';:0004672) <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0005524'>'ATP' == '' ? '': 'ATP'; 'binding' == '' ? '': 'binding'; ('GO' == '' ? '': 'GO';:0005524)

0
133-302 SSF53795 (n.a.) NULL 5.50002e-34
137-308 G3DSA:3.40.50.300 (n.a.) NULL 0
Protein Homology (BLASTP results)
Protein Start Protein End Hit Size Orthologous Organism Orthologous Start Orthologous End Evalue Identity Score Alignment
6 311 305 - MAG0890 Mycoplasma agalactiae 8 315 1e-31 27.707 321
156 271 115 - Caulobacter crescentus NA1000 25 132 0.000000001 30 136
25 297 272 - Lactococcus lactis subsp. lactis KF147 29 295 1e-25 25.4545 273
1 297 296 - Bacillus subtilis subsp. subtilis 1 295 4e-37 31.7726 376
1 297 296 - Bacillus subtilis subsp. subtilis 1 295 4e-37 31.7726 376
1 311 310 - MG085 Mycoplasma genitalium 1 311 <1e-50 69.1318 1101
1 309 308 - MSC_0940 Mycoplasma mycoides subsp. mycoides SC 1 313 2e-35 29.4304 354
1 309 308 - MCAP_0777 Mycoplasma capricolum subsp. capricolum 1 313 3e-35 29.1139 353
10 307 297 - MMOB1820 Mycoplasma mobile 19 319 8e-38 31.5113 374
1 302 301 - LIC_11546 Leptospira interrogans serovar Copenhage 3 303 3e-29 26.2295 305
6 299 293 - MYCGA7160 Mycoplasma gallisepticum 12 307 <1e-50 41.2162 604
52 293 241 - MYPE2990 Mycoplasma penetrans 47 287 4.99983e-42 34.8361 412
2 292 290 - Mycoplasma pulmonis 3 296 6e-29 27.4576 298
External IDs
COG 
COG1493T
EC number 
2.7.11.-
EC number 
2.7.4.-
Gene ID 
877117
GI 
13507962
GO 
Signal transduction mechanisms
Home COG 
T
InterPro 
IPR000276|Rhodopsin-like GPCR superfamily
InterPro 
IPR011104|HPr Serine kinase, C-terminal
InterPro 
IPR003755|HPr(Ser) kinase
InterPro 
IPR011126|HPr Serine kinase, N-terminal
Old MP number 
MP608
Pathway 
Regulation
PDB homologs 
1knx_A
Pfam 
PF07475
Pfam 
PF03970
Pfam 
PF02603
PID 
g1674310
RefSeq 
NP_109911.1
Swiss-Prot protein ID 
HPRK_MYCPN
phylomeDB tree 
HPRK_MYCPN
UniProt 
P75548
Transcription
IMAGE BROWSERS

OPERON OP93 (Genomic Overview)
Region:265662-273150

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STRING image

STRING of Mpn223STRING legend

PDB image(s)

1knx

PDB 1knx
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