MyMpn
The Mycoplasma pneumoniae database
 
e.g Mpn001 or dnaN or polymerase
Gene uvrD (MPN153)
Name 
uvrD
Stable ID 
MPN153
Location 
202383 - 205724 +
Sequence 
    1  ATGAACGACT GACAGTGACT CAAAAACCGG CTGGTTAACG CCAAAACTAA GGCTGTTAGT
   61  TTCTGGCTAG CCCAAACTAC CAGCACCATC TTAGATATTG CTGAACTAAT TAAATGTTGT
  121  TCGGATTTAA AGAATACTTC CATTAATGGG TTAGTTGATC TTATAAACCA ACAAGAAAAA
  181  CTCGAATTTA ACTTAACAAG GTTAAAGGAA ATTGATGGCG AGGATGCACG ACAGTTGTTT
  241  GGCATTGAAG GTAATGTTTA CAAACACTTC CAAACTGAAC TTAGTCGCTT TTACAAGCAA
  301  ACGCGCAAAC ACTTTCGCGA AACTGGTTCG GAAAGTCTCT TTTTAGGTTT ACCAGTAATT
  361  GAGGGCATTA ACGAGTTTAA CGATGTCTTT CGTGCTCCTT TACTCTATGT GGGGGTTAAG
  421  TTAAAAGTAG CACCACGACT TGAACGCTTT TGATTGGAAA TAAACCGCGA GGAAATCTTT
  481  TTAAATCCGA CCATCATCGG GGTTGAAATT AACAAGCGTA ACAGCTTGTT TAAAAATAAC
  541  TATGACACCA CTAAGGTTGA TATTAACCAG GCATTGGAAA TCTTTCGTGA GTTGGAATAC
  601  CAATTTCGGA TGCCACTCAC CTCGGAGTTA AAAAGTTTTT CCAAAAAGGC TAAGAGTGAC
  661  TTTAACACTG AAAAACGGAC TAACTTCCTC ACTAATAACG TTCTTTTAGG AATCTTTGAC
  721  GTTAAGGGGG ATCAACTGTT CCAAAACTTT AACGAAATTC TAAACACTGA TCCTGATGTT
  781  TTGGATGAAT TGTTAAAGGA TCGCCGCGAT CTCTTATACG ACAACCGTGA GTTTCGTGAA
  841  AACTTTAACT TAAAGGGCAC TTACCTCTTT AGCCACTTAG ACATCTTCCA GCAGTACGCT
  901  GTCAAACAGG CATTTGATGG GGATGTCATT ATTGAAGGTC CACCTGGTAC TGGTAAGAGT
  961  GAAACGATTG TCAACATCTT GGTCAACCTC GCTTTAAACA AAAAGAAGGT GTTGTTTGTG
 1021  TCAGAAAAGG TAACTGCCTT AGATGTCGTT TACAACCGGC TAGGTAGCTT TAAGCACATT
 1081  GCCTTATTTA ATGCTTCGGT AGCGAGTGAG AAGAAGCGCT TTTACAGCCA GTTCGCTGAT
 1141  TATGAAAGCT TCTTTACCGA TAACTTTTCC AAGAAGGATT TAGTTAACGA AATGCCGGTG
 1201  TTTGACGGGC AGTGGGTTGA TAAGATCCTA AGTGAATTCA CTAACCTTCA AAACATTTAC
 1261  GATACCCAAA TTAATTCGGG TAACCAGAGC TATTCCTTCA AGGAAATCCT AAGTAGTTTT
 1321  CCAATACTTG ATGTCAGTTA CATTAAGATC AAGGAACACG ATCGTTTTGA TGAATGAGTG
 1381  CGGGTATTTT CCTCACAAGT TTGATTAGAA AAACACTTAA CTTACTTAGC GTTTAAAGCG
 1441  GAACTGAGCA AACGCTGACA AAACATCGAT AACTTCTACG CTTTAAAAGA CTTACTGGAA
 1501  AAAAGAAAGA ACATCCGCGT GTTGTGCTAT GTGTTGGATT ACTTCGAGCA GAACAACAGC
 1561  ATAATCAAAC CGAAGCGGGT ATTGCTCTAT ACCCCCACTG AACGCGGGCA AAAGCAGTTG
 1621  CACCAACTCC AGCAAGACGT TGCTAAGTAC AACAGCTTGC AACGTTTTAA ATCGGCTGCT
 1681  AAGTTTGAAA CAATTAAGCT CAATTTAGCT AACAAACTAG CACAAAACGC CAAGCCTTTT
 1741  TTCTTTTCTT GATTCATTCA AACACACGCG CAAACACTGT TGGAAAATCT CGTACAAACC
 1801  CAAAAGCAAT TGGTTAAGGC TAAGCAAAGC TACTTAAGCA AAATTGAGCA GTATGTAGTT
 1861  AGTTGTAAAC GGATTCTCAA AGCTACCATT TTAGCCAACT TCTTTGAGTT GTACCAAACC
 1921  AATAAGAATG AACTATTGGA TATCTGTCGG GAAGCCAAAA ACCCTGTTTT AAAGGAAATT
 1981  ACCTGGTGGT TTAAGAAGAA CTTTGCACTG TTATCAAAGC TATTCCCCGT CCACATTATG
 2041  ACGTTTGAAT CAGCCGCCTT ATTAACCCCG AACCAGCGCC GTTTGTATGA CTATGTGGTG
 2101  ATTGATGAAG CTAGCCAGGT TTATCTAGAA CGTGCCATTC CAATCTTATA CCGTGGCGCT
 2161  AAGTACATTA TTGCTGGAGA CACCAAACAA TTAAAACCAT CCAATTTCTT CCAAGCCCGG
 2221  GCTGAGTATG ATGTGGATGA AGAGTTTGAA GATGGTAACG TTGAAGCTGC GGTGCACTCG
 2281  ACTTCGTTAC TACACTTTTT GAAGAACCGT TCGCGCATTT TAACGCTGCT CAAATTCCAC
 2341  TACCGCAGTG ATTCCGCTAA CCTAATTGCC TTTACTAATA ACCGCATTTA TAACAACGAG
 2401  CTCATCTTTA TGAATAAAGC AACCGCTGAC AAGCAGGTCT TTATTGTCCA TGATGTCATC
 2461  GATGGTATTT GACGGAACAA CCGTAACCTT CAAGAAGCAC GCGATGTCGT ACAACGCTTA
 2521  GAACAGTTGA CCCAAACTGC GGAATATCAA AAATCATTAG GGGTGATCTG TTTCAATAAA
 2581  AATCAGGCCG AGTTAATTGA GTACATGATT GACAAGCAGA ACAATCCGCT ACTCAATGAG
 2641  TGACGTGACC GGGTGAACGC TCAGGGCGAG TATGTCGGTT TGTTTGTCAA AAACATTGAA
 2701  AACGTTCAGG GTGATGAACG GGACATTATT ATCTTCTCGT TGGGCTATGA CCGTTCTGTC
 2761  AACAGCTATG GCCCGATTTC CAAGCAAGGT GGGGAGAACC GTTTGAATGT AGCGATTACC
 2821  CGTGCTAAGC AGCGGATTGA ACTGTTCAAG ACTAACCGTG CTAGTGATTA CAATGGTTTG
 2881  AGCTCCAATT CCTTGGGTAG TAAGTTATTG GTGGAATACT TACTGTACTG TGAGGCAATG
 2941  GCCAACAACC AGGGTGAGAG CTTAGACTTC CAAGCAACCC AAAAACAAGC ACCCAAGGCC
 3001  AAGTACGAAT TGGAATTGGA GAACCAGTTC TTTAATGAGT TGGAACTTAT TTTTGGTGAG
 3061  CAGTTTACGA TTAAACGCAA TGTCAATGAG GGTGCATACA GCTTTAGCTT TGTCTTTTAC
 3121  TTTAACGAAA ACCCTTACCT AGCGGTTGAC TTTAACCCTG CTTTACCCCA CTCCAGAAAG
 3181  GAAGTGAGTG AAAACATTAT TTACCGCGAA CAATTTTTGA AAAAGCGGAA ATGGAACCTC
 3241  GTTAACATTT GGTTAGACGA GTGAAAACTC AATCCAGGTG GTGTGTTGCA AAAGCTTAGA
 3301  AATTGTCTAA CTCACAGCGA AAATGAGTTT GAAGAAATAT AA
Download Sequence
Operon 
OP72
Operon location 
202358 - 207500
Protein (mpn153)
Name 
Probable DNA helicase I homolog (EC 3.6.1.-)
Stable ID 
Mpn153
Molecular Weight 
122430
Isoelectric Point 
8
Localization 
Cytoplasm
Comment UvrD is a superfamily I DNA helicase with well documented roles in excision repair and methyl-directed mismatch repair (MMR) in addition to poorly understood roles in replication and recombination. Nucleic Acids Research, 2006, Vol. 34, No. 15 4089-4097 UvrD plays a role of RecA nucleoprotein filament remover.
Sequence 
MNDWQWLKNRLVNAKTKAVSFWLAQTTSTILDIAELIKCCSDLKNTSINGLVDLINQQEKLEFNLTRLKEIDGEDARQLF
GIEGNVYKHFQTELSRFYKQTRKHFRETGSESLFLGLPVIEGINEFNDVFRAPLLYVGVKLKVAPRLERFWLEINREEIF
LNPTIIGVEINKRNSLFKNNYDTTKVDINQALEIFRELEYQFRMPLTSELKSFSKKAKSDFNTEKRTNFLTNNVLLGIFD
VKGDQLFQNFNEILNTDPDVLDELLKDRRDLLYDNREFRENFNLKGTYLFSHLDIFQQYAVKQAFDGDVIIEGPPGTGKS
ETIVNILVNLALNKKKVLFVSEKVTALDVVYNRLGSFKHIALFNASVASEKKRFYSQFADYESFFTDNFSKKDLVNEMPV
FDGQWVDKILSEFTNLQNIYDTQINSGNQSYSFKEILSSFPILDVSYIKIKEHDRFDEWVRVFSSQVWLEKHLTYLAFKA
ELSKRWQNIDNFYALKDLLEKRKNIRVLCYVLDYFEQNNSIIKPKRVLLYTPTERGQKQLHQLQQDVAKYNSLQRFKSAA
KFETIKLNLANKLAQNAKPFFFSWFIQTHAQTLLENLVQTQKQLVKAKQSYLSKIEQYVVSCKRILKATILANFFELYQT
NKNELLDICREAKNPVLKEITWWFKKNFALLSKLFPVHIMTFESAALLTPNQRRLYDYVVIDEASQVYLERAIPILYRGA
KYIIAGDTKQLKPSNFFQARAEYDVDEEFEDGNVEAAVHSTSLLHFLKNRSRILTLLKFHYRSDSANLIAFTNNRIYNNE
LIFMNKATADKQVFIVHDVIDGIWRNNRNLQEARDVVQRLEQLTQTAEYQKSLGVICFNKNQAELIEYMIDKQNNPLLNE
WRDRVNAQGEYVGLFVKNIENVQGDERDIIIFSLGYDRSVNSYGPISKQGGENRLNVAITRAKQRIELFKTNRASDYNGL
SSNSLGSKLLVEYLLYCEAMANNQGESLDFQATQKQAPKAKYELELENQFFNELELIFGEQFTIKRNVNEGAYSFSFVFY
FNENPYLAVDFNPALPHSRKEVSENIIYREQFLKKRKWNLVNIWLDEWKLNPGGVLQKLRNCLTHSENEFEEI
Post translational modifications
Modification Modified sequence Relative start Relative end Amino acid
Oxidation mNDWQWLK 1 9 M
Oxidation mPLTSELK 204 212 M
Oxidation DLVNEmPVFDGQWVDK 393 409 M
Methylation kNFALLSK 666 674 K
Oxidation IYNNELIFmNK 796 807 M
Oxidation NQAELIEYmIDK 861 873 M
GENE/PROTEIN uvrD (Domains Overview)
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Domains (InterProScan)
Location (aa) Name (InterPro ID) Description GO terms Sequence Evalue
3-954 PTHR10887 (n.a.) NULL 0
3-954 PTHR10887:SF7 (n.a.) NULL 0
282-946 SSF52540 (n.a.) NULL 2.50001e-37
295-337 G3DSA:3.40.50.300 (n.a.) NULL 0.0000000000047
526-591 G3DSA:3.40.50.300 (n.a.) NULL 0.0000000000047
682-734 G3DSA:3.40.50.300 (n.a.) NULL 0.0000000000047
781-958 G3DSA:3.40.50.300 (n.a.) NULL 0.000023
Protein Homology (BLASTP results)
Protein Start Protein End Hit Size Orthologous Organism Orthologous Start Orthologous End Evalue Identity Score Alignment
623 956 333 - MAG4780 Mycoplasma agalactiae 574 886 8e-37 33.432 371
297 381 84 - MAG4780 Mycoplasma agalactiae 324 409 0.00000005 34.8837 371
663 988 325 - MARTH_orf701 Mycoplasma arthritidis 610 917 1e-37 32.7327 377
297 363 66 - MARTH_orf701 Mycoplasma arthritidis 322 388 0.000003 38.806 377
696 1088 392 - MCJ_002580 Mycoplasma conjunctivae 967 1355 5e-26 27.0983 278
280 354 74 - MCJ_002580 Mycoplasma conjunctivae 320 395 0.0000004 35.5263 278
666 950 284 - MCJ_006700 Mycoplasma conjunctivae 631 896 2e-31 30.9028 324
670 956 286 - MHO_1080 Mycoplasma hominis 618 886 7e-35 32.5424 353
297 363 66 - MHO_1080 Mycoplasma hominis 322 388 0.00000009 41.791 353
658 1099 441 - MHO_2390 Mycoplasma hominis 898 1339 1e-35 28.27 359
285 374 89 - MHO_2390 Mycoplasma hominis 276 368 0.00000004 37.6344 359
1 1113 1112 - MG140 Mycoplasma genitalium 1 1113 <1e-50 74.124 4391
670 956 286 - MS53_0433 Mycoplasma synoviae 639 904 3e-31 31.9444 323
297 405 108 - MS53_0433 Mycoplasma synoviae 333 431 0.0000004 30.0885 323
666 956 290 - MHP7448_0592 Mycoplasma hyopneumoniae 7448 636 907 2e-33 31.4189 341
670 1103 433 - MHP7448_0064 Mycoplasma hyopneumoniae 7448 934 1356 3e-34 28.5714 349
281 398 117 - MHP7448_0064 Mycoplasma hyopneumoniae 7448 306 406 0.00000004 30.2521 349
692 956 264 - MMOB4990 Mycoplasma mobile 655 901 3e-33 34.0824 340
234 447 213 - MMOB4990 Mycoplasma mobile 276 495 0.00000007 27.4336 340
696 1093 397 - MSC_0658 Mycoplasma mycoides subsp. mycoides SC 96 484 1e-27 28.6058 292
294 354 60 - MSC_0656 Mycoplasma mycoides subsp. mycoides SC 309 370 0.000002 40.3226 110
2 1103 1101 - MYCGA0950 Mycoplasma gallisepticum 3 1117 <1e-50 44.1071 2428
670 956 286 - MYPE8460 Mycoplasma penetrans 832 1112 6e-39 37.8378 391
94 435 341 - MYPE8460 Mycoplasma penetrans 124 461 0.0000000000003 27.0492 391
696 956 260 - Mycoplasma pulmonis 653 893 4e-35 36.0902 357
278 401 123 - Mycoplasma pulmonis 315 435 0.0000000006 32 357
External IDs
COG 
COG1112L
EC number 
3.6.1.-
Gene ID 
877311
GI 
13507892
GO 
DNA replication, recombination and repair
Home COG 
L
Old MP number 
MP001
Pathway 
Division, DNA maintenance and repair
PDB homologs 
1qhg_A:1
PDB homologs 
1pjr_
PDB homologs 
3pjr_A
Pfam 
PF07728
PID 
g1673646
RefSeq 
NP_109841.1
Swiss-Prot protein ID 
Y153_MYCPN
phylomeDB tree 
Y153_MYCPN
UniProt 
P75033
Transcription
IMAGE BROWSERS

OPERON OP72 (Genomic Overview)
Region:202358-207500

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STRING image

STRING of Mpn153STRING legend

PDB image(s)

1qhg

PDB 1qhg

1pjr

PDB 1pjr

3pjr

PDB 3pjr
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