MyMpn
The Mycoplasma pneumoniae database
 
e.g Mpn001 or dnaN or polymerase
Gene lplA (MPN389)
Name 
lplA
Stable ID 
MPN389
Location 
465427 - 466446 -
Sequence 
    1  ATGAAAACTT ACATTCTCAC TTCCCCTAAA AACATTCCTT ACTTCAACGC AGCGTTAGAA
   61  GAATGGCTAC TCACCGAATT TAAAAAGGGC GAGGAAATTA AAGTCATTTA CTTCTGGCAA
  121  AACGCCAACA CGATTGTGGT GGGGCGCAAC CAAAATACGT ACGCTGAGGT TAACCTTAGT
  181  GAAGTGGAAA AGGACAAGGT TAATTTGTTT CGCCGTTTTT CTGGAGGTGG GGCGGTGTTT
  241  CATGACATGG GTAACATCTG TTTCTCAATT ATTTTGCCCA AAGCAAAAAA GGAAATGGAA
  301  AACGCTTATG AAGAAACAAC CCGTAATGTG GTGAAGTTCT TAAACAGTGT AGGTGTACCC
  361  GCACAGTTTC ATGGCCGCAA TGACTTGGAA ATTGAGGGCA AGAAGTTCTC TGGTTTAGCG
  421  GAATACCTCT CCAAAGACCG CGTGTTGGTC CACGGTACGT TGTTGTTTGA TACCGACTTT
  481  ACCAAGCTAG CGAAGTACCT CAATGTGGAT AAAACAAAAA TGGTAAGTAA GGGAATTGAA
  541  AGTGTCCAAA AACGGGTAGT TAACGTAAAA GAATACCTCC CCAACCTCTC TACCCCAACC
  601  TTCTTGGAAA AGATGGTGCA GTTCTTTACC GAAACCGAAC ATGCTGAAAC GATTCATTTG
  661  GATGAAAGCA GCATTAAGAT GGTGGAAAAA CGTGCACAGG AACACTTCCA ATCCTGGGAT
  721  TGAAACTTTG GTAAAACAGC TGACTACAAC TTTAAAAACA AGAAACGGTT TGAGGGTGCG
  781  GGCATCTTTG AATGTAACGT GCAGGTAGAT CAGGGTAAAG TAGTCGACAT TAAGTTCTAT
  841  GGGGACTTTT TGAGTGTTAT CGACATTACC CCCGTTACCC AGCAGTTGGT AGGACAAAAA
  901  TACGATTACC AAACCTTTGC TAAAATATTG GGTAACATTG ATAACTTTAA GGAGTACTTT
  961  GGTACCTTAA CACCTCAACA AATGCTCGAA GTTATCTTTG ATAACAAAAA GGATGAGTAA
Download Sequence
Operon 
OP439
Operon location 
464000 - 469068
Protein (mpn389)
Name 
Probable lipoate-protein ligase A (Lipoate--protein ligase) (EC 2.7.7.63)
Stable ID 
Mpn389
Molecular Weight 
37290
Isoelectric Point 
7
Localization 
Cytoplasm
Comment (RN:R07770) ATP + lipoate = diphosphate + lipoyl-AMP and (RN:R07771) lipoyl-AMP + apoprotein = protein N6-(lipoyl)lysine + AMP
Sequence 
MKTYILTSPKNIPYFNAALEEWLLTEFKKGEEIKVIYFWQNANTIVVGRNQNTYAEVNLSEVEKDKVNLFRRFSGGGAVF
HDMGNICFSIILPKAKKEMENAYEETTRNVVKFLNSVGVPAQFHGRNDLEIEGKKFSGLAEYLSKDRVLVHGTLLFDTDF
TKLAKYLNVDKTKMVSKGIESVQKRVVNVKEYLPNLSTPTFLEKMVQFFTETEHAETIHLDESSIKMVEKRAQEHFQSWD
WNFGKTADYNFKNKKRFEGAGIFECNVQVDQGKVVDIKFYGDFLSVIDITPVTQQLVGQKYDYQTFAKILGNIDNFKEYF
GTLTPQQMLEVIFDNKKDE
Post translational modifications
Modification Modified sequence Relative start Relative end Amino acid
Oxidation mKTYILTSPK 1 11 M
Oxidation rFSGGGAVFHDmGNIcFSIILPk 72 95 M
Oxidation AKKEmENAYEETTR 95 109 M
Oxidation kEmENAYEETTr 97 109 M
Oxidation KEmENAYEETTR 97 109 M
Oxidation KEmENAYEETTRNVVK 97 113 M
Oxidation EmENAYEETTr 98 109 M
Oxidation EmENAYEETTR 98 109 M
Oxidation mVSKGIESVQKR 174 186 M
Oxidation mVQFFTETEHAETIHLDESSIK 205 227 M
Oxidation mVQFFTETEHAETIHLDESSIKmVEKR 205 232 M
Oxidation ILGNIDNFKEYFGTLTPQQmLEVIFDNKKDE 309 340 M
GENE/PROTEIN lplA (Domains Overview)
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Domains (InterProScan)
Location (aa) Name (InterPro ID) Description GO terms Sequence Evalue
1-327 TIGR00545 (IPR004562) Lipoyltransferase/lipoate-protein ligase Biological Process:
<'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0009249'>'protein' == '' ? '': 'protein'; 'lipoylation' == '' ? '': 'lipoylation'; ('GO' == '' ? '': 'GO';:0009249)

Molecular Function:
<'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0016740'>'transferase' == '' ? '': 'transferase'; 'activity' == '' ? '': 'activity'; ('GO' == '' ? '': 'GO';:0016740)

0
2-244 G3DSA:3.90.1550.10 (n.a.) NULL 0
3-244 SSF55681 (n.a.) NULL 0
5-291 PTHR12561 (n.a.) NULL 1.7e-32
47-159 PF03099 (IPR004143) Biotin/lipoate A/B protein ligase Biological Process:
<'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0006464'>'protein' == '' ? '': 'protein'; 'modification' == '' ? '': 'modification'; 'process' == '' ? '': 'process'; ('GO' == '' ? '': 'GO';:0006464)

Molecular Function:
<'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0003824'>'catalytic' == '' ? '': 'catalytic'; 'activity' == '' ? '': 'activity'; ('GO' == '' ? '': 'GO';:0003824)

6.8e-19
245-332 PF10437 (IPR019491) Lipoate protein ligase, C-terminal 3.1e-21
245-333 G3DSA:3.30.390.50 (IPR005107) CO dehydrogenase flavoprotein, C-terminal 1.4e-23
245-334 SSF82649 (n.a.) NULL 1.7e-20
Protein Homology (BLASTP results)
Protein Start Protein End Hit Size Orthologous Organism Orthologous Start Orthologous End Evalue Identity Score Alignment
5 301 296 - b4386 Escherichia coli 6 303 <1e-50 36.5696 477
1 333 332 - MAG0600 Mycoplasma agalactiae 1 325 <1e-50 38.0531 559
18 334 316 - MAG0070 Mycoplasma agalactiae 21 343 5e-29 24.5399 298
18 192 174 - MAG0060 Mycoplasma agalactiae 21 195 0.000000000000003 27.5281 180
5 333 328 - MCJ_003870 Mycoplasma conjunctivae 3 330 <1e-50 36.2018 547
18 333 315 - MCJ_004210 Mycoplasma conjunctivae 21 342 1e-28 26.3804 295
5 314 309 - MCAP_0224 Mycoplasma capricolum subsp. capricolum 4 313 <1e-50 37.5796 599
22 334 312 - MCAP_0449 Mycoplasma capricolum subsp. capricolum 19 343 5e-29 25.0765 300
8 336 328 - MYCGA4810 Mycoplasma gallisepticum 7 331 <1e-50 46.9697 794
1 336 335 - MG270 Mycoplasma genitalium 1 336 <1e-50 75.8929 1398
1 333 332 - MHP7448_0254 Mycoplasma hyopneumoniae 7448 1 330 <1e-50 34.8083 457
18 300 282 - MHP7448_0310 Mycoplasma hyopneumoniae 7448 21 309 2e-32 31.7406 329
1 333 332 - MMOB0580 Mycoplasma mobile 1 327 <1e-50 37.3529 532
5 314 309 - MSC_0264 Mycoplasma mycoides subsp. mycoides SC 4 313 <1e-50 36.9427 591
22 334 312 - MSC_0527 Mycoplasma mycoides subsp. mycoides SC 19 343 3e-29 25.0765 302
1 335 334 - MYPE8650 Mycoplasma penetrans 1 327 <1e-50 37.0149 520
13 333 320 - MS53_0060 Mycoplasma synoviae 11 325 <1e-50 39.7516 574
13 331 318 - Lactococcus lactis subsp. lactis KF147 11 325 <1e-50 36.5625 574
11 333 322 - Bacillus subtilis subsp. subtilis 10 331 <1e-50 33.945 553
11 333 322 - Bacillus subtilis subsp. subtilis 10 331 <1e-50 33.945 551
13 245 232 - Bacillus subtilis subsp. subtilis 16 278 0.000000000004 25 160
18 245 227 - Bacillus subtilis subsp. subtilis 2 259 0.00000000002 24.7104 154
5 338 333 - Mycoplasma pulmonis 15 341 <1e-50 39.403 620
15 333 318 - Mycoplasma pulmonis 18 343 6e-34 28.7009 342
External IDs
COG 
COG0095H
EC number 
2.7.7.63
Gene ID 
877079
GI 
13508128
GO 
Post-translational modification, protein turnover, chaperones
Home COG 
O
InterPro 
IPR004562|Lipoyltransferase and lipoate-protein ligase
InterPro 
IPR004143|Biotin/lipoate A/B protein ligase
Old MP number 
MP449
Pathway 
Metabolism lipid
PDB homologs 
1bia_
PDB homologs 
1bib_
PDB homologs 
1hxd_A
Pfam 
PF03099
PID 
g1674137
RefSeq 
NP_110077.1
Swiss-Prot protein ID 
LPLA_MYCPN
phylomeDB tree 
LPLA_MYCPN
UniProt 
P75394
Transcription
IMAGE BROWSERS

OPERON OP439 (Genomic Overview)
Region:464000-469068

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STRING image

STRING of Mpn389STRING legend

PDB image(s)

1bia

PDB 1bia

1bib

PDB 1bib

1hxd

PDB 1hxd
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