Table S13: Synthetic Lethal and Sick Interactions in In Silico Double Knock-OutsTable S13: Synthetic Lethal and Sick Interactions in In Silico Double Knock-OutsTable S13: Synthetic Lethal and Sick Interactions in In Silico Double Knock-OutsTable S13: Synthetic Lethal and Sick Interactions in In Silico Double Knock-OutsTable S13: Synthetic Lethal and Sick Interactions in In Silico Double Knock-OutsTable S13: Synthetic Lethal and Sick Interactions in In Silico Double Knock-OutsTable S13: Synthetic Lethal and Sick Interactions in In Silico Double Knock-OutsTable S13: Synthetic Lethal and Sick Interactions in In Silico Double Knock-OutsTable S13: Synthetic Lethal and Sick Interactions in In Silico Double Knock-OutsTable S13: Synthetic Lethal and Sick Interactions in In Silico Double Knock-OutsTable S13: Synthetic Lethal and Sick Interactions in In Silico Double Knock-OutsTable S13: Synthetic Lethal and Sick Interactions in In Silico Double Knock-OutsTable S13: Synthetic Lethal and Sick Interactions in In Silico Double Knock-OutsTable S13: Synthetic Lethal and Sick Interactions in In Silico Double Knock-OutsTable S13: Synthetic Lethal and Sick Interactions in In Silico Double Knock-OutsTable S13: Synthetic Lethal and Sick Interactions in In Silico Double Knock-OutsTable S13: Synthetic Lethal and Sick Interactions in In Silico Double Knock-OutsTable S13: Synthetic Lethal and Sick Interactions in In Silico Double Knock-OutsTable S13: Synthetic Lethal and Sick Interactions in In Silico Double Knock-OutsTable S13: Synthetic Lethal and Sick Interactions in In Silico Double Knock-OutsTable S13: Synthetic Lethal and Sick Interactions in In Silico Double Knock-OutsTable S13: Synthetic Lethal and Sick Interactions in In Silico Double Knock-OutsTable S13: Synthetic Lethal and Sick Interactions in In Silico Double Knock-OutsTable S13: Synthetic Lethal and Sick Interactions in In Silico Double Knock-OutsTable S13: Synthetic Lethal and Sick Interactions in In Silico Double Knock-OutsTable S13: Synthetic Lethal and Sick Interactions in In Silico Double Knock-OutsTable S13: Synthetic Lethal and Sick Interactions in In Silico Double Knock-OutsTable S13: Synthetic Lethal and Sick Interactions in In Silico Double Knock-OutsTable S13: Synthetic Lethal and Sick Interactions in In Silico Double Knock-OutsTable S13: Synthetic Lethal and Sick Interactions in In Silico Double Knock-OutsTable S13: Synthetic Lethal and Sick Interactions in In Silico Double Knock-OutsTable S13: Synthetic Lethal and Sick Interactions in In Silico Double Knock-OutsTable S13: Synthetic Lethal and Sick Interactions in In Silico Double Knock-OutsTable S13: Synthetic Lethal and Sick Interactions in In Silico Double Knock-OutsTable S13: Synthetic Lethal and Sick Interactions in In Silico Double Knock-OutsTable S13: Synthetic Lethal and Sick Interactions in In Silico Double Knock-Outs Gene 1 Pathway 1 Gene 2 Pathway 2 Interaction type MPN033 NT metabolism MPN043 sugar metabolism sick MPN033 NT metabolism MPN044 NT metabolism sick MPN033 NT metabolism MPN050 sugar metabolism sick MPN033 NT metabolism MPN051 glycolysis/lipid metbaolism sick MPN033 NT metabolism MPN062 NT metabolism sick MPN033 NT metabolism MPN064 NT metabolism sick MPN033 NT metabolism MPN065 NT metabolism sick MPN033 NT metabolism MPN073 PPP synthetic lethal MPN033 NT metabolism MPN082 PPP sick MPN033 NT metabolism MPN133 sugar metabolism sick MPN033 NT metabolism MPN134 sugar metabolism sick MPN033 NT metabolism MPN135 sugar metabolism sick MPN033 NT metabolism MPN136 sugar metabolism sick MPN033 NT metabolism MPN251 PPP sick MPN033 NT metabolism MPN258 sugar metabolism sick MPN033 NT metabolism MPN259 sugar metabolism sick MPN033 NT metabolism MPN260 sugar metabolism sick MPN033 NT metabolism MPN306 amino acid metabolism sick MPN033 NT metabolism MPN307 amino acid metabolism sick MPN033 NT metabolism MPN320 folate metabolism sick MPN033 NT metabolism MPN386 NT metabolism sick MPN033 NT metabolism MPN390 pyruvate metabolism sick MPN033 NT metabolism MPN391 pyruvate metabolism sick MPN033 NT metabolism MPN392 pyruvate metabolism sick MPN033 NT metabolism MPN393 pyruvate metabolism sick MPN033 NT metabolism MPN394 pyruvate metabolism sick MPN033 NT metabolism MPN428 pyruvate metabolism sick MPN033 NT metabolism MPN533 pyruvate metabolism sick MPN033 NT metabolism MPN595 PPP sick MPN033 NT metabolism MPN674 pyruvate metabolism sick MPN043 sugar metabolism MPN044 NT metabolism sick MPN043 sugar metabolism MPN051 glycolysis/lipid metbaolism sick MPN043 sugar metabolism MPN062 NT metabolism sick MPN043 sugar metabolism MPN064 NT metabolism sick MPN043 sugar metabolism MPN065 NT metabolism sick MPN043 sugar metabolism MPN082 PPP sick MPN043 sugar metabolism MPN133 sugar metabolism synthetic lethal MPN043 sugar metabolism MPN134 sugar metabolism synthetic lethal MPN043 sugar metabolism MPN135 sugar metabolism synthetic lethal MPN043 sugar metabolism MPN136 sugar metabolism synthetic lethal MPN043 sugar metabolism MPN251 PPP sick MPN043 sugar metabolism MPN258 sugar metabolism sick MPN043 sugar metabolism MPN259 sugar metabolism sick MPN043 sugar metabolism MPN260 sugar metabolism sick MPN043 sugar metabolism MPN306 amino acid metabolism sick MPN043 sugar metabolism MPN307 amino acid metabolism sick MPN043 sugar metabolism MPN320 folate metabolism sick MPN043 sugar metabolism MPN386 NT metabolism sick MPN043 sugar metabolism MPN390 pyruvate metabolism sick MPN043 sugar metabolism MPN391 pyruvate metabolism sick MPN043 sugar metabolism MPN392 pyruvate metabolism sick MPN043 sugar metabolism MPN393 pyruvate metabolism sick MPN043 sugar metabolism MPN394 pyruvate metabolism sick MPN043 sugar metabolism MPN428 pyruvate metabolism sick MPN043 sugar metabolism MPN533 pyruvate metabolism sick MPN043 sugar metabolism MPN595 PPP sick MPN043 sugar metabolism MPN674 pyruvate metabolism sick MPN044 NT metabolism MPN050 sugar metabolism sick MPN044 NT metabolism MPN051 glycolysis/lipid metbaolism sick MPN044 NT metabolism MPN062 NT metabolism sick MPN044 NT metabolism MPN064 NT metabolism sick MPN044 NT metabolism MPN065 NT metabolism sick MPN044 NT metabolism MPN082 PPP sick MPN044 NT metabolism MPN133 sugar metabolism sick MPN044 NT metabolism MPN134 sugar metabolism sick MPN044 NT metabolism MPN135 sugar metabolism sick MPN044 NT metabolism MPN136 sugar metabolism sick MPN044 NT metabolism MPN251 PPP sick MPN044 NT metabolism MPN258 sugar metabolism sick MPN044 NT metabolism MPN259 sugar metabolism sick MPN044 NT metabolism MPN260 sugar metabolism sick MPN044 NT metabolism MPN306 amino acid metabolism sick MPN044 NT metabolism MPN307 amino acid metabolism sick MPN044 NT metabolism MPN320 folate metabolism synthetic lethal MPN044 NT metabolism MPN386 NT metabolism sick MPN044 NT metabolism MPN390 pyruvate metabolism sick MPN044 NT metabolism MPN391 pyruvate metabolism sick MPN044 NT metabolism MPN392 pyruvate metabolism sick MPN044 NT metabolism MPN393 pyruvate metabolism sick MPN044 NT metabolism MPN394 pyruvate metabolism sick MPN044 NT metabolism MPN428 pyruvate metabolism sick MPN044 NT metabolism MPN533 pyruvate metabolism sick MPN044 NT metabolism MPN595 PPP sick MPN044 NT metabolism MPN674 pyruvate metabolism sick MPN050 sugar metabolism MPN051 glycolysis/lipid metbaolism sick MPN050 sugar metabolism MPN062 NT metabolism sick MPN050 sugar metabolism MPN064 NT metabolism sick MPN050 sugar metabolism MPN065 NT metabolism sick MPN050 sugar metabolism MPN082 PPP sick MPN050 sugar metabolism MPN133 sugar metabolism synthetic lethal MPN050 sugar metabolism MPN134 sugar metabolism synthetic lethal MPN050 sugar metabolism MPN135 sugar metabolism synthetic lethal MPN050 sugar metabolism MPN136 sugar metabolism synthetic lethal MPN050 sugar metabolism MPN251 PPP sick MPN050 sugar metabolism MPN258 sugar metabolism sick MPN050 sugar metabolism MPN259 sugar metabolism sick MPN050 sugar metabolism MPN260 sugar metabolism sick MPN050 sugar metabolism MPN306 amino acid metabolism sick MPN050 sugar metabolism MPN307 amino acid metabolism sick MPN050 sugar metabolism MPN320 folate metabolism sick MPN050 sugar metabolism MPN386 NT metabolism sick MPN050 sugar metabolism MPN390 pyruvate metabolism sick MPN050 sugar metabolism MPN391 pyruvate metabolism sick MPN050 sugar metabolism MPN392 pyruvate metabolism sick MPN050 sugar metabolism MPN393 pyruvate metabolism sick MPN050 sugar metabolism MPN394 pyruvate metabolism sick MPN050 sugar metabolism MPN428 pyruvate metabolism sick MPN050 sugar metabolism MPN533 pyruvate metabolism sick MPN050 sugar metabolism MPN595 PPP sick MPN050 sugar metabolism MPN674 pyruvate metabolism sick MPN051 glycolysis/lipid metbaolism MPN062 NT metabolism sick MPN051 glycolysis/lipid metbaolism MPN064 NT metabolism sick MPN051 glycolysis/lipid metbaolism MPN065 NT metabolism sick MPN051 glycolysis/lipid metbaolism MPN082 PPP sick MPN051 glycolysis/lipid metbaolism MPN251 PPP sick MPN051 glycolysis/lipid metbaolism MPN258 sugar metabolism sick MPN051 glycolysis/lipid metbaolism MPN259 sugar metabolism sick MPN051 glycolysis/lipid metbaolism MPN260 sugar metabolism sick MPN051 glycolysis/lipid metbaolism MPN306 amino acid metabolism sick MPN051 glycolysis/lipid metbaolism MPN307 amino acid metabolism sick MPN051 glycolysis/lipid metbaolism MPN320 folate metabolism sick MPN051 glycolysis/lipid metbaolism MPN386 NT metabolism sick MPN051 glycolysis/lipid metbaolism MPN390 pyruvate metabolism sick MPN051 glycolysis/lipid metbaolism MPN391 pyruvate metabolism sick MPN051 glycolysis/lipid metbaolism MPN392 pyruvate metabolism sick MPN051 glycolysis/lipid metbaolism MPN393 pyruvate metabolism sick MPN051 glycolysis/lipid metbaolism MPN394 pyruvate metabolism sick MPN051 glycolysis/lipid metbaolism MPN428 pyruvate metabolism sick MPN051 glycolysis/lipid metbaolism MPN533 pyruvate metabolism sick MPN051 glycolysis/lipid metbaolism MPN595 PPP sick MPN051 glycolysis/lipid metbaolism MPN674 pyruvate metabolism sick MPN062 NT metabolism MPN064 NT metabolism sick MPN062 NT metabolism MPN065 NT metabolism sick MPN062 NT metabolism MPN082 PPP sick MPN062 NT metabolism MPN133 sugar metabolism sick MPN062 NT metabolism MPN134 sugar metabolism sick MPN062 NT metabolism MPN135 sugar metabolism sick MPN062 NT metabolism MPN136 sugar metabolism sick MPN062 NT metabolism MPN251 PPP sick MPN062 NT metabolism MPN258 sugar metabolism sick MPN062 NT metabolism MPN259 sugar metabolism sick MPN062 NT metabolism MPN260 sugar metabolism sick MPN062 NT metabolism MPN306 amino acid metabolism sick MPN062 NT metabolism MPN307 amino acid metabolism sick MPN062 NT metabolism MPN320 folate metabolism sick MPN062 NT metabolism MPN386 NT metabolism sick MPN062 NT metabolism MPN390 pyruvate metabolism sick MPN062 NT metabolism MPN391 pyruvate metabolism sick MPN062 NT metabolism MPN392 pyruvate metabolism sick MPN062 NT metabolism MPN393 pyruvate metabolism sick MPN062 NT metabolism MPN394 pyruvate metabolism sick MPN062 NT metabolism MPN428 pyruvate metabolism sick MPN062 NT metabolism MPN533 pyruvate metabolism sick MPN062 NT metabolism MPN595 PPP sick MPN062 NT metabolism MPN674 pyruvate metabolism sick MPN064 NT metabolism MPN065 NT metabolism sick MPN064 NT metabolism MPN073 PPP synthetic lethal MPN064 NT metabolism MPN082 PPP sick MPN064 NT metabolism MPN133 sugar metabolism sick MPN064 NT metabolism MPN134 sugar metabolism sick MPN064 NT metabolism MPN135 sugar metabolism sick MPN064 NT metabolism MPN136 sugar metabolism sick MPN064 NT metabolism MPN251 PPP sick MPN064 NT metabolism MPN258 sugar metabolism sick MPN064 NT metabolism MPN259 sugar metabolism sick MPN064 NT metabolism MPN260 sugar metabolism sick MPN064 NT metabolism MPN306 amino acid metabolism sick MPN064 NT metabolism MPN307 amino acid metabolism sick MPN064 NT metabolism MPN320 folate metabolism synthetic lethal MPN064 NT metabolism MPN386 NT metabolism sick MPN064 NT metabolism MPN390 pyruvate metabolism sick MPN064 NT metabolism MPN391 pyruvate metabolism sick MPN064 NT metabolism MPN392 pyruvate metabolism sick MPN064 NT metabolism MPN393 pyruvate metabolism sick MPN064 NT metabolism MPN394 pyruvate metabolism sick MPN064 NT metabolism MPN428 pyruvate metabolism sick MPN064 NT metabolism MPN533 pyruvate metabolism sick MPN064 NT metabolism MPN595 PPP sick MPN064 NT metabolism MPN674 pyruvate metabolism sick MPN065 NT metabolism MPN082 PPP sick MPN065 NT metabolism MPN133 sugar metabolism sick MPN065 NT metabolism MPN134 sugar metabolism sick MPN065 NT metabolism MPN135 sugar metabolism sick MPN065 NT metabolism MPN136 sugar metabolism sick MPN065 NT metabolism MPN251 PPP sick MPN065 NT metabolism MPN258 sugar metabolism sick MPN065 NT metabolism MPN259 sugar metabolism sick MPN065 NT metabolism MPN260 sugar metabolism sick MPN065 NT metabolism MPN306 amino acid metabolism sick MPN065 NT metabolism MPN307 amino acid metabolism sick MPN065 NT metabolism MPN386 NT metabolism sick MPN065 NT metabolism MPN390 pyruvate metabolism sick MPN065 NT metabolism MPN391 pyruvate metabolism sick MPN065 NT metabolism MPN392 pyruvate metabolism sick MPN065 NT metabolism MPN393 pyruvate metabolism sick MPN065 NT metabolism MPN394 pyruvate metabolism sick MPN065 NT metabolism MPN428 pyruvate metabolism sick MPN065 NT metabolism MPN533 pyruvate metabolism sick MPN065 NT metabolism MPN595 PPP sick MPN065 NT metabolism MPN674 pyruvate metabolism sick MPN073 PPP MPN082 PPP sick MPN073 PPP MPN133 sugar metabolism sick MPN073 PPP MPN134 sugar metabolism sick MPN073 PPP MPN135 sugar metabolism sick MPN073 PPP MPN136 sugar metabolism sick MPN073 PPP MPN251 PPP sick MPN073 PPP MPN258 sugar metabolism sick MPN073 PPP MPN259 sugar metabolism sick MPN073 PPP MPN260 sugar metabolism sick MPN073 PPP MPN306 amino acid metabolism sick MPN073 PPP MPN307 amino acid metabolism sick MPN073 PPP MPN320 folate metabolism sick MPN073 PPP MPN386 NT metabolism sick MPN073 PPP MPN390 pyruvate metabolism sick MPN073 PPP MPN391 pyruvate metabolism sick MPN073 PPP MPN392 pyruvate metabolism sick MPN073 PPP MPN393 pyruvate metabolism sick MPN073 PPP MPN394 pyruvate metabolism sick MPN073 PPP MPN428 pyruvate metabolism sick MPN073 PPP MPN533 pyruvate metabolism sick MPN073 PPP MPN595 PPP sick MPN073 PPP MPN674 pyruvate metabolism sick MPN078 sugar metabolism MPN082 PPP sick MPN078 sugar metabolism MPN133 sugar metabolism sick MPN078 sugar metabolism MPN134 sugar metabolism sick MPN078 sugar metabolism MPN135 sugar metabolism sick MPN078 sugar metabolism MPN136 sugar metabolism sick MPN078 sugar metabolism MPN251 PPP sick MPN078 sugar metabolism MPN258 sugar metabolism sick MPN078 sugar metabolism MPN259 sugar metabolism sick MPN078 sugar metabolism MPN260 sugar metabolism sick MPN078 sugar metabolism MPN306 amino acid metabolism sick MPN078 sugar metabolism MPN307 amino acid metabolism sick MPN078 sugar metabolism MPN320 folate metabolism sick MPN078 sugar metabolism MPN386 NT metabolism sick MPN078 sugar metabolism MPN390 pyruvate metabolism sick MPN078 sugar metabolism MPN391 pyruvate metabolism sick MPN078 sugar metabolism MPN392 pyruvate metabolism sick MPN078 sugar metabolism MPN393 pyruvate metabolism sick MPN078 sugar metabolism MPN394 pyruvate metabolism sick MPN078 sugar metabolism MPN428 pyruvate metabolism sick MPN078 sugar metabolism MPN533 pyruvate metabolism sick MPN078 sugar metabolism MPN595 PPP sick MPN078 sugar metabolism MPN674 pyruvate metabolism sick MPN079 sugar metabolism MPN082 PPP sick MPN079 sugar metabolism MPN133 sugar metabolism sick MPN079 sugar metabolism MPN134 sugar metabolism sick MPN079 sugar metabolism MPN135 sugar metabolism sick MPN079 sugar metabolism MPN136 sugar metabolism sick MPN079 sugar metabolism MPN251 PPP sick MPN079 sugar metabolism MPN258 sugar metabolism sick MPN079 sugar metabolism MPN259 sugar metabolism sick MPN079 sugar metabolism MPN260 sugar metabolism sick MPN079 sugar metabolism MPN306 amino acid metabolism sick MPN079 sugar metabolism MPN307 amino acid metabolism sick MPN079 sugar metabolism MPN320 folate metabolism sick MPN079 sugar metabolism MPN386 NT metabolism sick MPN079 sugar metabolism MPN390 pyruvate metabolism sick MPN079 sugar metabolism MPN391 pyruvate metabolism sick MPN079 sugar metabolism MPN392 pyruvate metabolism sick MPN079 sugar metabolism MPN393 pyruvate metabolism sick MPN079 sugar metabolism MPN394 pyruvate metabolism sick MPN079 sugar metabolism MPN428 pyruvate metabolism sick MPN079 sugar metabolism MPN533 pyruvate metabolism sick MPN079 sugar metabolism MPN595 PPP sick MPN079 sugar metabolism MPN674 pyruvate metabolism sick MPN082 PPP MPN133 sugar metabolism sick MPN082 PPP MPN134 sugar metabolism sick MPN082 PPP MPN135 sugar metabolism sick MPN082 PPP MPN136 sugar metabolism sick MPN082 PPP MPN258 sugar metabolism synthetic lethal MPN082 PPP MPN259 sugar metabolism synthetic lethal MPN082 PPP MPN260 sugar metabolism synthetic lethal MPN082 PPP MPN306 amino acid metabolism sick MPN082 PPP MPN307 amino acid metabolism sick MPN082 PPP MPN320 folate metabolism sick MPN082 PPP MPN386 NT metabolism sick MPN082 PPP MPN390 pyruvate metabolism sick MPN082 PPP MPN391 pyruvate metabolism sick MPN082 PPP MPN392 pyruvate metabolism sick MPN082 PPP MPN393 pyruvate metabolism sick MPN082 PPP MPN394 pyruvate metabolism sick MPN082 PPP MPN428 pyruvate metabolism sick MPN082 PPP MPN533 pyruvate metabolism sick MPN082 PPP MPN674 pyruvate metabolism sick MPN108 amino acid metabolism MPN082 PPP sick MPN108 amino acid metabolism MPN133 sugar metabolism sick MPN108 amino acid metabolism MPN134 sugar metabolism sick MPN108 amino acid metabolism MPN135 sugar metabolism sick MPN108 amino acid metabolism MPN136 sugar metabolism sick MPN108 amino acid metabolism MPN251 PPP sick MPN108 amino acid metabolism MPN258 sugar metabolism sick MPN108 amino acid metabolism MPN259 sugar metabolism sick MPN108 amino acid metabolism MPN260 sugar metabolism sick MPN108 amino acid metabolism MPN306 amino acid metabolism sick MPN108 amino acid metabolism MPN307 amino acid metabolism sick MPN108 amino acid metabolism MPN320 folate metabolism sick MPN108 amino acid metabolism MPN386 NT metabolism sick MPN108 amino acid metabolism MPN390 pyruvate metabolism sick MPN108 amino acid metabolism MPN391 pyruvate metabolism sick MPN108 amino acid metabolism MPN392 pyruvate metabolism sick MPN108 amino acid metabolism MPN393 pyruvate metabolism sick MPN108 amino acid metabolism MPN394 pyruvate metabolism sick MPN108 amino acid metabolism MPN428 pyruvate metabolism sick MPN108 amino acid metabolism MPN533 pyruvate metabolism sick MPN108 amino acid metabolism MPN595 PPP sick MPN108 amino acid metabolism MPN674 pyruvate metabolism sick MPN133 sugar metabolism MPN134 sugar metabolism sick MPN133 sugar metabolism MPN135 sugar metabolism sick MPN133 sugar metabolism MPN136 sugar metabolism sick MPN133 sugar metabolism MPN251 PPP sick MPN133 sugar metabolism MPN258 sugar metabolism sick MPN133 sugar metabolism MPN259 sugar metabolism sick MPN133 sugar metabolism MPN260 sugar metabolism sick MPN133 sugar metabolism MPN306 amino acid metabolism sick MPN133 sugar metabolism MPN307 amino acid metabolism sick MPN133 sugar metabolism MPN320 folate metabolism sick MPN133 sugar metabolism MPN386 NT metabolism sick MPN133 sugar metabolism MPN390 pyruvate metabolism sick MPN133 sugar metabolism MPN391 pyruvate metabolism sick MPN133 sugar metabolism MPN392 pyruvate metabolism sick MPN133 sugar metabolism MPN393 pyruvate metabolism sick MPN133 sugar metabolism MPN394 pyruvate metabolism sick MPN133 sugar metabolism MPN428 pyruvate metabolism sick MPN133 sugar metabolism MPN533 pyruvate metabolism sick MPN133 sugar metabolism MPN595 PPP sick MPN133 sugar metabolism MPN674 pyruvate metabolism sick MPN134 sugar metabolism MPN135 sugar metabolism sick MPN134 sugar metabolism MPN136 sugar metabolism sick MPN134 sugar metabolism MPN251 PPP sick MPN134 sugar metabolism MPN258 sugar metabolism sick MPN134 sugar metabolism MPN259 sugar metabolism sick MPN134 sugar metabolism MPN260 sugar metabolism sick MPN134 sugar metabolism MPN306 amino acid metabolism sick MPN134 sugar metabolism MPN307 amino acid metabolism sick MPN134 sugar metabolism MPN320 folate metabolism sick MPN134 sugar metabolism MPN386 NT metabolism sick MPN134 sugar metabolism MPN390 pyruvate metabolism sick MPN134 sugar metabolism MPN391 pyruvate metabolism sick MPN134 sugar metabolism MPN392 pyruvate metabolism sick MPN134 sugar metabolism MPN393 pyruvate metabolism sick MPN134 sugar metabolism MPN394 pyruvate metabolism sick MPN134 sugar metabolism MPN428 pyruvate metabolism sick MPN134 sugar metabolism MPN533 pyruvate metabolism sick MPN134 sugar metabolism MPN595 PPP sick MPN134 sugar metabolism MPN674 pyruvate metabolism sick MPN135 sugar metabolism MPN136 sugar metabolism sick MPN135 sugar metabolism MPN251 PPP sick MPN135 sugar metabolism MPN258 sugar metabolism sick MPN135 sugar metabolism MPN259 sugar metabolism sick MPN135 sugar metabolism MPN260 sugar metabolism sick MPN135 sugar metabolism MPN306 amino acid metabolism sick MPN135 sugar metabolism MPN307 amino acid metabolism sick MPN135 sugar metabolism MPN320 folate metabolism sick MPN135 sugar metabolism MPN386 NT metabolism sick MPN135 sugar metabolism MPN390 pyruvate metabolism sick MPN135 sugar metabolism MPN391 pyruvate metabolism sick MPN135 sugar metabolism MPN392 pyruvate metabolism sick MPN135 sugar metabolism MPN393 pyruvate metabolism sick MPN135 sugar metabolism MPN394 pyruvate metabolism sick MPN135 sugar metabolism MPN428 pyruvate metabolism sick MPN135 sugar metabolism MPN533 pyruvate metabolism sick MPN135 sugar metabolism MPN595 PPP sick MPN135 sugar metabolism MPN674 pyruvate metabolism sick MPN136 sugar metabolism MPN251 PPP sick MPN136 sugar metabolism MPN258 sugar metabolism sick MPN136 sugar metabolism MPN259 sugar metabolism sick MPN136 sugar metabolism MPN260 sugar metabolism sick MPN136 sugar metabolism MPN306 amino acid metabolism sick MPN136 sugar metabolism MPN307 amino acid metabolism sick MPN136 sugar metabolism MPN320 folate metabolism sick MPN136 sugar metabolism MPN386 NT metabolism sick MPN136 sugar metabolism MPN390 pyruvate metabolism sick MPN136 sugar metabolism MPN391 pyruvate metabolism sick MPN136 sugar metabolism MPN392 pyruvate metabolism sick MPN136 sugar metabolism MPN393 pyruvate metabolism sick MPN136 sugar metabolism MPN394 pyruvate metabolism sick MPN136 sugar metabolism MPN428 pyruvate metabolism sick MPN136 sugar metabolism MPN533 pyruvate metabolism sick MPN136 sugar metabolism MPN595 PPP sick MPN136 sugar metabolism MPN674 pyruvate metabolism sick MPN251 PPP MPN258 sugar metabolism synthetic lethal MPN251 PPP MPN259 sugar metabolism synthetic lethal MPN251 PPP MPN260 sugar metabolism synthetic lethal MPN251 PPP MPN306 amino acid metabolism sick MPN251 PPP MPN307 amino acid metabolism sick MPN251 PPP MPN320 folate metabolism sick MPN251 PPP MPN386 NT metabolism sick MPN251 PPP MPN390 pyruvate metabolism sick MPN251 PPP MPN391 pyruvate metabolism sick MPN251 PPP MPN392 pyruvate metabolism sick MPN251 PPP MPN393 pyruvate metabolism sick MPN251 PPP MPN394 pyruvate metabolism sick MPN251 PPP MPN428 pyruvate metabolism sick MPN251 PPP MPN533 pyruvate metabolism sick MPN251 PPP MPN674 pyruvate metabolism sick MPN253 lipid metabolism MPN258 sugar metabolism sick MPN253 lipid metabolism MPN259 sugar metabolism sick MPN253 lipid metabolism MPN260 sugar metabolism sick MPN253 lipid metabolism MPN306 amino acid metabolism sick MPN253 lipid metabolism MPN307 amino acid metabolism sick MPN253 lipid metabolism MPN320 folate metabolism sick MPN253 lipid metabolism MPN386 NT metabolism sick MPN253 lipid metabolism MPN390 pyruvate metabolism sick MPN253 lipid metabolism MPN391 pyruvate metabolism sick MPN253 lipid metabolism MPN392 pyruvate metabolism sick MPN253 lipid metabolism MPN393 pyruvate metabolism sick MPN253 lipid metabolism MPN394 pyruvate metabolism sick MPN253 lipid metabolism MPN428 pyruvate metabolism sick MPN253 lipid metabolism MPN533 pyruvate metabolism sick MPN253 lipid metabolism MPN595 PPP sick MPN253 lipid metabolism MPN674 pyruvate metabolism sick MPN258 sugar metabolism MPN306 amino acid metabolism sick MPN258 sugar metabolism MPN307 amino acid metabolism sick MPN258 sugar metabolism MPN320 folate metabolism sick MPN258 sugar metabolism MPN386 NT metabolism sick MPN258 sugar metabolism MPN390 pyruvate metabolism sick MPN258 sugar metabolism MPN391 pyruvate metabolism sick MPN258 sugar metabolism MPN392 pyruvate metabolism sick MPN258 sugar metabolism MPN393 pyruvate metabolism sick MPN258 sugar metabolism MPN394 pyruvate metabolism sick MPN258 sugar metabolism MPN428 pyruvate metabolism sick MPN258 sugar metabolism MPN533 pyruvate metabolism sick MPN258 sugar metabolism MPN595 PPP synthetic lethal MPN258 sugar metabolism MPN674 pyruvate metabolism sick MPN259 sugar metabolism MPN306 amino acid metabolism sick MPN259 sugar metabolism MPN307 amino acid metabolism sick MPN259 sugar metabolism MPN320 folate metabolism sick MPN259 sugar metabolism MPN386 NT metabolism sick MPN259 sugar metabolism MPN390 pyruvate metabolism sick MPN259 sugar metabolism MPN391 pyruvate metabolism sick MPN259 sugar metabolism MPN392 pyruvate metabolism sick MPN259 sugar metabolism MPN393 pyruvate metabolism sick MPN259 sugar metabolism MPN394 pyruvate metabolism sick MPN259 sugar metabolism MPN428 pyruvate metabolism sick MPN259 sugar metabolism MPN533 pyruvate metabolism sick MPN259 sugar metabolism MPN595 PPP synthetic lethal MPN259 sugar metabolism MPN674 pyruvate metabolism sick MPN260 sugar metabolism MPN306 amino acid metabolism sick MPN260 sugar metabolism MPN307 amino acid metabolism sick MPN260 sugar metabolism MPN320 folate metabolism sick MPN260 sugar metabolism MPN386 NT metabolism sick MPN260 sugar metabolism MPN390 pyruvate metabolism sick MPN260 sugar metabolism MPN391 pyruvate metabolism sick MPN260 sugar metabolism MPN392 pyruvate metabolism sick MPN260 sugar metabolism MPN393 pyruvate metabolism sick MPN260 sugar metabolism MPN394 pyruvate metabolism sick MPN260 sugar metabolism MPN428 pyruvate metabolism sick MPN260 sugar metabolism MPN533 pyruvate metabolism sick MPN260 sugar metabolism MPN595 PPP synthetic lethal MPN260 sugar metabolism MPN674 pyruvate metabolism sick MPN300 folate metabolism MPN306 amino acid metabolism sick MPN300 folate metabolism MPN307 amino acid metabolism sick MPN300 folate metabolism MPN320 folate metabolism sick MPN300 folate metabolism MPN321 folate metabolism synthetic lethal MPN300 folate metabolism MPN386 NT metabolism sick MPN300 folate metabolism MPN390 pyruvate metabolism sick MPN300 folate metabolism MPN391 pyruvate metabolism sick MPN300 folate metabolism MPN392 pyruvate metabolism sick MPN300 folate metabolism MPN393 pyruvate metabolism sick MPN300 folate metabolism MPN394 pyruvate metabolism sick MPN300 folate metabolism MPN428 pyruvate metabolism sick MPN300 folate metabolism MPN533 pyruvate metabolism sick MPN300 folate metabolism MPN595 PPP sick MPN300 folate metabolism MPN674 pyruvate metabolism sick MPN304 amino acid metabolism MPN306 amino acid metabolism sick MPN304 amino acid metabolism MPN307 amino acid metabolism sick MPN304 amino acid metabolism MPN320 folate metabolism sick MPN304 amino acid metabolism MPN386 NT metabolism sick MPN304 amino acid metabolism MPN390 pyruvate metabolism sick MPN304 amino acid metabolism MPN391 pyruvate metabolism sick MPN304 amino acid metabolism MPN392 pyruvate metabolism sick MPN304 amino acid metabolism MPN393 pyruvate metabolism sick MPN304 amino acid metabolism MPN394 pyruvate metabolism sick MPN304 amino acid metabolism MPN428 pyruvate metabolism sick MPN304 amino acid metabolism MPN533 pyruvate metabolism sick MPN304 amino acid metabolism MPN595 PPP sick MPN304 amino acid metabolism MPN674 pyruvate metabolism sick MPN305 amino acid metabolism MPN306 amino acid metabolism sick MPN305 amino acid metabolism MPN307 amino acid metabolism sick MPN305 amino acid metabolism MPN320 folate metabolism sick MPN305 amino acid metabolism MPN386 NT metabolism sick MPN305 amino acid metabolism MPN390 pyruvate metabolism sick MPN305 amino acid metabolism MPN391 pyruvate metabolism sick MPN305 amino acid metabolism MPN392 pyruvate metabolism sick MPN305 amino acid metabolism MPN393 pyruvate metabolism sick MPN305 amino acid metabolism MPN394 pyruvate metabolism sick MPN305 amino acid metabolism MPN428 pyruvate metabolism sick MPN305 amino acid metabolism MPN533 pyruvate metabolism sick MPN305 amino acid metabolism MPN595 PPP sick MPN305 amino acid metabolism MPN674 pyruvate metabolism sick MPN306 amino acid metabolism MPN320 folate metabolism sick MPN306 amino acid metabolism MPN386 NT metabolism sick MPN306 amino acid metabolism MPN390 pyruvate metabolism sick MPN306 amino acid metabolism MPN391 pyruvate metabolism sick MPN306 amino acid metabolism MPN392 pyruvate metabolism sick MPN306 amino acid metabolism MPN393 pyruvate metabolism sick MPN306 amino acid metabolism MPN394 pyruvate metabolism sick MPN306 amino acid metabolism MPN428 pyruvate metabolism sick MPN306 amino acid metabolism MPN533 pyruvate metabolism sick MPN306 amino acid metabolism MPN595 PPP sick MPN306 amino acid metabolism MPN674 pyruvate metabolism sick MPN307 amino acid metabolism MPN320 folate metabolism sick MPN307 amino acid metabolism MPN386 NT metabolism sick MPN307 amino acid metabolism MPN390 pyruvate metabolism sick MPN307 amino acid metabolism MPN391 pyruvate metabolism sick MPN307 amino acid metabolism MPN392 pyruvate metabolism sick MPN307 amino acid metabolism MPN393 pyruvate metabolism sick MPN307 amino acid metabolism MPN394 pyruvate metabolism sick MPN307 amino acid metabolism MPN428 pyruvate metabolism sick MPN307 amino acid metabolism MPN533 pyruvate metabolism sick MPN307 amino acid metabolism MPN595 PPP sick MPN307 amino acid metabolism MPN674 pyruvate metabolism sick MPN320 folate metabolism MPN386 NT metabolism sick MPN320 folate metabolism MPN390 pyruvate metabolism sick MPN320 folate metabolism MPN391 pyruvate metabolism sick MPN320 folate metabolism MPN392 pyruvate metabolism sick MPN320 folate metabolism MPN393 pyruvate metabolism sick MPN320 folate metabolism MPN394 pyruvate metabolism sick MPN320 folate metabolism MPN428 pyruvate metabolism sick MPN320 folate metabolism MPN533 pyruvate metabolism sick MPN320 folate metabolism MPN595 PPP sick MPN320 folate metabolism MPN674 pyruvate metabolism sick MPN321 folate metabolism MPN386 NT metabolism sick MPN321 folate metabolism MPN390 pyruvate metabolism sick MPN321 folate metabolism MPN391 pyruvate metabolism sick MPN321 folate metabolism MPN392 pyruvate metabolism sick MPN321 folate metabolism MPN393 pyruvate metabolism sick MPN321 folate metabolism MPN394 pyruvate metabolism sick MPN321 folate metabolism MPN428 pyruvate metabolism sick MPN321 folate metabolism MPN533 pyruvate metabolism sick MPN321 folate metabolism MPN595 PPP sick MPN321 folate metabolism MPN674 pyruvate metabolism sick MPN386 NT metabolism MPN390 pyruvate metabolism sick MPN386 NT metabolism MPN391 pyruvate metabolism sick MPN386 NT metabolism MPN392 pyruvate metabolism sick MPN386 NT metabolism MPN393 pyruvate metabolism sick MPN386 NT metabolism MPN394 pyruvate metabolism sick MPN386 NT metabolism MPN428 pyruvate metabolism sick MPN386 NT metabolism MPN533 pyruvate metabolism sick MPN386 NT metabolism MPN595 PPP sick MPN386 NT metabolism MPN674 pyruvate metabolism sick MPN390 pyruvate metabolism MPN394 pyruvate metabolism sick MPN390 pyruvate metabolism MPN595 PPP sick MPN390 pyruvate metabolism MPN674 pyruvate metabolism synthetic lethal MPN391 pyruvate metabolism MPN394 pyruvate metabolism sick MPN391 pyruvate metabolism MPN420 lipid metabolism sick MPN391 pyruvate metabolism MPN595 PPP sick MPN391 pyruvate metabolism MPN674 pyruvate metabolism synthetic lethal MPN392 pyruvate metabolism MPN394 pyruvate metabolism sick MPN392 pyruvate metabolism MPN595 PPP sick MPN392 pyruvate metabolism MPN674 pyruvate metabolism synthetic lethal MPN393 pyruvate metabolism MPN394 pyruvate metabolism sick MPN393 pyruvate metabolism MPN595 PPP sick MPN393 pyruvate metabolism MPN674 pyruvate metabolism synthetic lethal MPN394 pyruvate metabolism MPN428 pyruvate metabolism sick MPN394 pyruvate metabolism MPN533 pyruvate metabolism sick MPN394 pyruvate metabolism MPN595 PPP sick MPN394 pyruvate metabolism MPN674 pyruvate metabolism synthetic lethal MPN420 lipid metabolism MPN428 pyruvate metabolism sick MPN420 lipid metabolism MPN533 pyruvate metabolism sick MPN420 lipid metabolism MPN595 PPP sick MPN420 lipid metabolism MPN674 pyruvate metabolism sick MPN428 pyruvate metabolism MPN595 PPP sick MPN428 pyruvate metabolism MPN674 pyruvate metabolism synthetic lethal MPN445 lipid metabolism MPN533 pyruvate metabolism sick MPN445 lipid metabolism MPN595 PPP sick MPN445 lipid metabolism MPN674 pyruvate metabolism sick MPN479 CoA metabolism MPN533 pyruvate metabolism sick MPN479 CoA metabolism MPN595 PPP sick MPN479 CoA metabolism MPN674 pyruvate metabolism sick MPN492 PPP MPN533 pyruvate metabolism sick MPN492 PPP MPN595 PPP sick MPN492 PPP MPN674 pyruvate metabolism sick MPN493 sugar metabolism MPN533 pyruvate metabolism sick MPN493 sugar metabolism MPN595 PPP sick MPN493 sugar metabolism MPN674 pyruvate metabolism sick MPN494 sugar metabolism MPN533 pyruvate metabolism sick MPN494 sugar metabolism MPN595 PPP sick MPN494 sugar metabolism MPN674 pyruvate metabolism sick MPN495 sugar metabolism MPN533 pyruvate metabolism sick MPN495 sugar metabolism MPN595 PPP sick MPN495 sugar metabolism MPN674 pyruvate metabolism sick MPN496 sugar metabolism MPN533 pyruvate metabolism sick MPN496 sugar metabolism MPN595 PPP sick MPN496 sugar metabolism MPN674 pyruvate metabolism sick MPN497 sugar metabolism MPN533 pyruvate metabolism sick MPN497 sugar metabolism MPN595 PPP sick MPN497 sugar metabolism MPN674 pyruvate metabolism sick MPN498 PPP MPN533 pyruvate metabolism sick MPN498 PPP MPN595 PPP sick MPN498 PPP MPN674 pyruvate metabolism sick MPN533 pyruvate metabolism MPN595 PPP sick MPN533 pyruvate metabolism MPN674 pyruvate metabolism synthetic lethal MPN560 amino acid metabolism MPN674 pyruvate metabolism sick MPN564 pyruvate metabolism MPN674 pyruvate metabolism sick MPN595 PPP MPN674 pyruvate metabolism sick MPN609 sugar metabolism MPN674 pyruvate metabolism sick MPN610 sugar metabolism MPN674 pyruvate metabolism sick MPN611 sugar metabolism MPN674 pyruvate metabolism sick MPN637 lipid metabolism MPN674 pyruvate metabolism sick MPN651 sugar metabolism MPN674 pyruvate metabolism sick MPN652 sugar metabolism MPN674 pyruvate metabolism sick MPN653 sugar metabolism MPN674 pyruvate metabolism sick Table S13: Synthetic Lethal and Sick Interactions in In Silico Double Knock-Outs: Pairs of genes with their respective pathway affiliations and the type of interaction when simulating double knock-outs in silico are shown (compare figure 8).