Table S10: Flux Variability Analysis (FVA) model ID min_24h max_24h min_36h max_36h min_48h max_48h min_60h max_60h pathway M001 5.10835881 5.10836 7.36899839 7.369 9.69713896 9.69714 12.37759938 12.3776 Glycolysis M002 5.08380749 5.08380869 7.34112419 7.3411258 9.67773088 9.67773191 12.36839105 12.36839167 Glycolysis M003 5.16247758 5.16247877 7.45653307 7.45653468 9.83433298 9.83433402 12.57241513 12.57241637 Glycolysis M004 5.16247758 5.16247877 7.45653307 7.45653468 9.83433298 9.83433402 12.57241513 12.57241637 Glycolysis M005 -5.40843868 -5.40843629 -7.81424649 -7.81424326 -10.3117133 -10.31171122 -13.18774897 -13.18774773 Glycolysis M006 10.6102501 10.6102525 15.32848239 15.32848562 20.2243463 20.22434838 25.86217645 25.86217768 Glycolysis M007 -15.53157647 -10.38723138 -22.70321278 -15.10461496 -30.17747349 -20.00264122 -38.78553329 -25.64307652 Glycolysis M008 -10.6102525 -10.6102501 -15.32848562 -15.32848239 -20.22434838 -20.2243463 -25.86217768 -25.86217645 Glycolysis M009 10.6102501 10.6102525 15.32848239 15.32848562 20.2243463 20.22434838 25.86217645 25.86217768 Glycolysis M010 0 5.1443427 0 7.5985946 0 10.17483019 0 13.14245554 Glycolysis M011 -3.16665488 -3.1666501 -8.39738883 -8.39738239 -15.60525045 -15.6052463 -23.18447892 -23.18447645 Pyruvate metabolism M012 7.44359761 7.4436 6.93109678 6.9311 4.61909792 4.6191 2.67769814 2.6777 Pyruvate metabolism M013 -7.4436 -7.44359761 -6.9311 -6.93109678 -4.6191 -4.61909792 -2.6777 -2.67769814 Pyruvate metabolism M014 7.44359761 7.4436 6.93109678 6.9311 4.61909792 4.6191 2.67769814 2.6777 Pyruvate metabolism M015 7.44359761 7.4436 6.93109678 6.9311 4.61909792 4.6191 2.67769876 2.6777 Pyruvate metabolism M016 -7.4436 -7.44359761 -6.9311 -6.93109678 -4.6191 -4.61909792 -2.6777 -2.67769876 Pyruvate metabolism M017 7.44281029 7.44281268 6.93015567 6.93015889 4.61854862 4.6185507 2.67757164 2.67757492 Pyruvate metabolism M018 0.09230929 0.09231018 0.10075356 0.10075476 0.07923903 0.07923981 0.05339366 0.05339412 Energy metabolism M019 0 0 0 0 0 0 0 0 Alternative sugar metabolism M020 0 0 0 0 0 0 0 0 Alternative sugar metabolism M021 0 0 0 0 0 0 0 0 Alternative sugar metabolism M022 0 0 0 0 0 0 0 0 Alternative sugar metabolism M023 0 0 0 0 0 0 0 0 Alternative sugar metabolism M024 0 0 0 0 0 0 0 0 Alternative sugar metabolism M025 0 0 0 0 0 0 0 0 Alternative sugar metabolism M026 0 0 0 0 0 0 0 0 Alternative sugar metabolism M027 0 0 0 0 0 0 0 0 Alternative sugar metabolism M028 0 0 0 0 0 0 0 0 Alternative sugar metabolism M029 0 0 0 0 0 0 0 0 Alternative sugar metabolism M030 0 0 0 0 0 0 0 0 Alternative sugar metabolism M031 0 0 0 0 0 0 0 0 Alternative sugar metabolism M032 0.12770757 0.127709 0.18422307 0.184225 0.24242675 0.242428 0.30943926 0.30944 Pentose phosphate pathway M033 0.12770757 0.127709 0.18422307 0.184225 0.24242675 0.242428 0.30943926 0.30944 Pentose phosphate pathway M034 -0.03933504 -0.03933457 -0.05770444 -0.0577038 -0.07830106 -0.07830064 -0.10201235 -0.10201173 Pentose phosphate pathway M035 0.03933457 0.03933504 0.0577038 0.05770444 0.07830064 0.07830106 0.10201173 0.10201235 Pentose phosphate pathway M036 -0.03933504 -0.03933457 -0.05770444 -0.0577038 -0.07830106 -0.07830064 -0.10201235 -0.10201173 Pentose phosphate pathway M037 0.07866913 0.07867009 0.11540759 0.11540888 0.15660128 0.15660211 0.20402346 0.2040247 Pentose phosphate pathway M038 0.07866913 0.07867009 0.11540759 0.11540888 0.15660128 0.15660211 0.20402346 0.2040247 Pentose phosphate pathway M039 0 2.38926E-006 0 3.22371E-006 0 2.07861E-006 0 1.23881E-006 Pentose phosphate pathway M040 -0.00970446 -0.00970148 -0.01111248 -0.01110846 -0.00752535 -0.00752276 -0.00340481 -0.00340171 Pentose phosphate pathway M041 0 0.000000195 0 2.6316E-007 0 1.69682E-007 0 1.85821E-006 Pentose phosphate pathway M042 0 0.000000195 0 2.6316E-007 0 1.69682E-007 0 1.85821E-006 Pentose phosphate pathway M043 0 0.000000195 0 2.6316E-007 0 1.69682E-007 0 1.85821E-006 Alternative sugar metabolism M044 -0.127709 -0.12770661 -0.184225 -0.18422178 -0.242428 -0.24242592 -0.30944 -0.30943876 Lipid metabolism M045 0.12770661 0.127709 0.18422178 0.184225 0.24242592 0.242428 0.30943876 0.30944 Lipid metabolism M046 0.12770661 0.127709 0.18422178 0.184225 0.24242592 0.242428 0.30943876 0.30944 Lipid metabolism M047 0.24595752 0.24595991 0.35770858 0.35771181 0.47737719 0.47737927 0.61533136 0.6153326 Lipid metabolism M048 0.01 0.01000239 0.01 0.01000322 0.01 0.01000208 0.01 0.01000124 Lipid metabolism M049 0.01 0.01000239 0.01 0.01000322 0.01 0.01000208 0.01 0.01000124 Lipid metabolism M050 0.00945809 0.0094581 0.01073819 0.01073821 0.00747673 0.00747674 0.0035474 0.0035474 Lipid metabolism M051 0.00945809 0.0094581 0.01073819 0.01073821 0.00747673 0.00747674 0.0035474 0.0035474 Lipid metabolism M052 0 0 0 0 0 0 0 0 Lipid metabolism M053 0 0 0 0 0 0 0 0 Lipid metabolism M054 0 0 0 0 0 0 0 0 Lipid metabolism M055 0 0 0 0 0 0 0 0 Lipid metabolism M056 0.00284372 0.00284373 0.0032286 0.00322861 0.00224799 0.002248 0.00106658 0.00106658 Lipid metabolism M057 -0.01706235 -0.01706234 -0.01937165 -0.01937163 -0.01348798 -0.01348797 -0.00639949 -0.00639948 Lipid metabolism M058 0.01706234 0.01706235 0.01937163 0.01937165 0.01348797 0.01348798 0.00639948 0.00639949 Lipid metabolism M059 0.00853117 0.00853118 0.00968581 0.00968582 0.00674398 0.00674399 0.00319974 0.00319974 Lipid metabolism M060 0.00284372 0.00284373 0.0032286 0.00322861 0.00224799 0.002248 0.00106658 0.00106658 Lipid metabolism M061 4.4641E-006 4.46411E-006 5.06829E-006 5.0683E-006 3.52892E-006 3.52893E-006 1.67433E-006 1.67433E-006 Lipid metabolism M062 4.4641E-006 4.46411E-006 5.06829E-006 5.0683E-006 3.52892E-006 3.52893E-006 1.67433E-006 1.67433E-006 Lipid metabolism M063 0 0 0 0 0 0 0 0 Lipid metabolism M064 0 0 0 0 0 0 0 0 Lipid metabolism M065 -0.00433861 -0.00294637 -0.00497355 -0.00339236 -0.00335682 -0.00225604 -0.00160902 -0.00098676 Nucleotide metabolism M066 -0.00008843 -0.00008604 -0.0001004 -0.00009718 -0.00006991 -0.00006783 -0.00003317 -0.00003193 Nucleotide metabolism M067 0 2.38926E-006 0 3.22371E-006 0 2.07861E-006 0 1.23881E-006 Nucleotide metabolism M068 0.61423093 0.61562317 0.6507833 0.65236448 0.55765442 0.55875519 0.44565459 0.44627684 Nucleotide metabolism M069 0 0.00139006 0 0.00157824 0 0.00109887 0 0.00062112 Nucleotide metabolism M070 0.00138985 0.00139006 0.00157796 0.00157824 0.00109869 0.00109887 0.00061642 0.00062112 Nucleotide metabolism M071 0.00783095 0.00783096 0.00784313 0.00784314 0.00781211 0.00781212 0.00777474 0.00777474 Nucleotide metabolism M072 1.19479945 1.19480184 1.23554175 1.23554497 1.13173768 1.13173976 1.00687667 1.0068779 Nucleotide metabolism M073 -0.00225131 -0.00086119 -0.00255602 -0.0009777 -0.00177969 -0.00068076 -0.00084443 -0.00022324 Nucleotide metabolism M074 0.00086119 0.00225131 0.0009777 0.00255602 0.00068076 0.00177969 0.00022324 0.00084443 Nucleotide metabolism M075 0.00086119 0.00225131 0.0009777 0.00255602 0.00068076 0.00177969 0.00022324 0.00084443 Nucleotide metabolism M076 0 5.1443427 0 7.5985946 0 10.17483019 0 13.14245554 Nucleotide metabolism M077 -0.00225131 5.14209145 -0.00255602 7.59603866 -0.00177969 10.17305055 -0.00084443 13.14161117 Nucleotide metabolism M078 0.00007504 0.00007504 0.0000852 0.0000852 0.00005932 0.00005932 0.00002815 0.00002815 Nucleotide metabolism M079 -0.00391089 -0.00251865 -0.00444072 -0.00285953 -0.00309179 -0.00199102 -0.00156691 -0.00094466 Nucleotide metabolism M080 -0.00007397 -0.00007158 -0.00008398 -0.00008076 -0.00005847 -0.0000564 -0.00002774 -0.0000265 Nucleotide metabolism M081 0 2.38926E-006 0 3.22371E-006 0 2.07861E-006 0 1.23881E-006 Nucleotide metabolism M082 0.21926665 0.22065678 0.21960753 0.22118587 0.21873902 0.21983796 0.21769266 0.21831381 Nucleotide metabolism M083 0 0.00139006 0 0.00157824 0 0.00109887 0 0.00062112 Nucleotide metabolism M084 0 5.1443427 0 7.5985946 0 10.17483019 0 13.14245554 Nucleotide metabolism M085 -0.21926693 4.92507605 -0.21960791 7.37898706 -0.21873926 9.95609117 -0.2176928 12.92476288 Nucleotide metabolism M086 -0.00150087 -0.00011077 -0.00170402 -0.00012572 -0.00118646 -0.00008755 -0.00056295 0.00005821 Nucleotide metabolism M087 0.00011077 0.00150087 0.00012572 0.00170402 0.00008755 0.00118646 -0.00005821 0.00056295 Nucleotide metabolism M088 0.00011077 0.00150087 0.00012572 0.00170402 0.00008755 0.00118646 -0.00005821 0.00056295 Nucleotide metabolism M089 0 5.1443427 0 7.5985946 0 10.17483019 0 13.14245554 Nucleotide metabolism M090 -0.00150087 5.14284187 -0.00170402 7.59689064 -0.00118646 10.17364376 -0.00056295 13.14189263 Nucleotide metabolism M091 0.005787 0.00718163 0.00666417 0.00824858 0.00442832 0.00553117 0.00193353 0.00255702 Nucleotide metabolism M092 -0.00954386 -0.00953908 -0.01093052 -0.01092407 -0.00739853 -0.00739438 -0.0033439 -0.0033408 Nucleotide metabolism M093 0 2.38926E-006 0 3.22371E-006 0 2.07861E-006 0 1.23881E-006 Nucleotide metabolism M094 0.00942565 0.00943042 0.01079529 0.01080173 0.00730471 0.00730886 0.00329826 0.00340046 Nucleotide metabolism M095 0.19577379 0.19716389 0.19607815 0.19765645 0.19530269 0.19640161 0.19436844 0.19498958 Nucleotide metabolism M096 0.21283613 0.21283638 0.21544978 0.21545012 0.20879066 0.20879088 0.20076792 0.20076805 Nucleotide metabolism M097 0 0.00139006 0 0.00157824 0 0.00109887 0 0.00062112 Nucleotide metabolism M098 0 2.06267E-007 0 2.78306E-007 0 1.79448E-007 0 0.00009983 Nucleotide metabolism M099 0.00162359 0.00162598 0.00184334 0.00184656 0.00128347 0.00128555 0.00060895 0.00070992 Nucleotide metabolism M100 0 2.38926E-006 0 3.22371E-006 0 2.07861E-006 0 1.23881E-006 Nucleotide metabolism M101 0.14096159 0.1409618 0.14118134 0.14118162 0.14062147 0.14062165 0.13994695 0.14004679 Nucleotide metabolism M102 0.14096159 0.14096177 0.14118134 0.14118158 0.14062147 0.14062162 0.13994695 0.13994705 Nucleotide metabolism M103 0 2.06267E-007 0 2.78306E-007 0 1.79448E-007 0 0.00009983 Nucleotide metabolism M104 0.00150063 0.00150322 0.00170368 0.00170718 0.00118624 0.0011885 0.00046308 0.00056415 Nucleotide metabolism M105 0 2.38926E-006 0 3.22371E-006 0 2.07861E-006 0 1.23881E-006 Nucleotide metabolism M106 0.00150063 0.00150087 0.00170368 0.00170402 0.00118624 0.00118646 0.00046308 0.00056295 Nucleotide metabolism M107 0.00150083 0.00150087 0.00170396 0.00170402 0.00118642 0.00118646 0.00056291 0.00056295 Nucleotide metabolism M108 0.00466871 0.00466898 0.00530055 0.00530091 0.00369065 0.00369088 0.00165131 0.00175121 Nucleotide metabolism M109 0.00236202 0.00375227 0.00268166 0.00426016 0.00186719 0.00296623 0.00078615 0.00140913 Nucleotide metabolism M110 0.00091648 0.00230908 0.00104044 0.00262211 0.00072446 0.00182554 0.0002434 0.0008664 Nucleotide metabolism M111 0 2.38926E-006 0 3.22371E-006 0 2.07861E-006 0 1.2388E-006 Nucleotide metabolism M112 -0.00139006 0 -0.00157824 0 -0.00109887 0 -0.00062112 0 Nucleotide metabolism M113 0.00230651 0.00230675 0.00261865 0.00261897 0.00182331 0.00182352 0.00086442 0.00086522 Nucleotide metabolism M114 -1.80322E-007 0 -2.43299E-007 0 -1.56876E-007 0 -7.43283E-007 0 Nucleotide metabolism M115 0 2.38926E-006 0 3.22371E-006 0 2.07861E-006 0 1.2388E-006 Nucleotide metabolism M116 0.00005526 0.00005783 0.0000627 0.00006617 0.00004367 0.00004591 0.00002005 0.00002203 Nucleotide metabolism M117 0.00225125 0.00225131 0.00255594 0.00255602 0.00177964 0.00177969 0.00084436 0.00084443 Nucleotide metabolism M118 0.00225125 0.00225131 0.00255594 0.00255602 0.00177964 0.00177969 0.00084436 0.00084443 Nucleotide metabolism M119 0.24050889 0.24051128 0.23922381 0.23922704 0.24249698 0.24249906 0.24643988 0.24644112 Amino acid metabolism M120 -0.24051128 -0.24050889 -0.23922704 -0.23922381 -0.24249906 -0.24249698 -0.24644112 -0.24643988 Amino acid metabolism M121 -0.24051128 -0.24050889 -0.23922704 -0.23922381 -0.24249906 -0.24249698 -0.24644112 -0.24643988 Amino acid metabolism M122 -4.46411E-006 -4.4641E-006 -5.0683E-006 -5.06829E-006 -3.52893E-006 -3.52892E-006 -1.67433E-006 -1.67433E-006 One carbon pool by folate M123 -0.00231122 -0.00231097 -0.00262404 -0.00262371 -0.00182705 -0.00182684 -0.0008669 -0.00086609 One carbon pool by folate M124 0 1.89875E-007 0 2.56189E-007 0 1.65187E-007 0 1.23881E-006 One carbon pool by folate M125 0.00106529 0.00106548 0.00116221 0.00116246 0.0009152 0.00091536 0.00061642 0.00061766 One carbon pool by folate M126 0.00106548 0.00106548 0.00116246 0.00116246 0.00091536 0.00091536 0.00061766 0.00061766 One carbon pool by folate M127 -0.00337669 -0.00337644 -0.0037865 -0.00378616 -0.00274241 -0.00274219 -0.00148456 -0.00148326 One carbon pool by folate M128 0.00106975 0.00106994 0.00116727 0.00116753 0.00091873 0.00091889 0.0006181 0.00061934 One carbon pool by folate M129 0.00999554 0.00999793 0.00999493 0.00999816 0.00999647 0.00999855 0.00999833 0.00999956 One carbon pool by folate M130 0.01 0.01000239 0.01 0.01000322 0.01 0.01000208 0.01 0.01000124 One carbon pool by folate M131 0.00106515 0.00106534 0.00116205 0.00116231 0.00091509 0.00091526 0.00061637 0.00061761 One carbon pool by folate M132 4.4641E-006 4.46617E-006 5.06829E-006 5.07108E-006 3.52892E-006 3.53072E-006 1.67433E-006 1.67647E-006 Amino acid metabolism M133 0 2.06639E-009 0 2.78807E-009 0 1.79771E-009 0 2.14667E-009 Amino acid metabolism M134 0 2.06639E-009 0 2.78807E-009 0 1.79771E-009 0 2.14667E-009 Amino acid metabolism M135 -0.00032458 -0.00032437 -0.00041578 -0.0004155 -0.00018351 -0.00018333 -3.4556E-006 -3.34865E-006 Cofactor metabolism M136 0.00032437 0.00032458 0.0004155 0.00041578 0.00018333 0.00018351 3.34865E-006 3.4556E-006 Cofactor metabolism M137 0.00032437 0.00032458 0.0004155 0.00041578 0.00018333 0.00018351 3.34865E-006 3.4556E-006 Cofactor metabolism M138 0 2.06267E-007 0 2.78306E-007 0 1.79448E-007 0 3.4556E-006 Cofactor metabolism M139 0.00032437 0.00032458 0.0004155 0.00041578 0.00018333 0.00018351 0 3.4556E-006 Cofactor metabolism M140 4.4641E-006 4.46411E-006 5.06829E-006 5.0683E-006 3.52892E-006 3.52893E-006 1.67433E-006 1.67433E-006 Cofactor metabolism M141 4.4641E-006 4.46411E-006 5.06829E-006 5.0683E-006 3.52892E-006 3.52893E-006 1.67433E-006 1.67433E-006 Cofactor metabolism M142 4.4641E-006 4.46411E-006 5.06829E-006 5.0683E-006 3.52892E-006 3.52893E-006 1.67433E-006 1.67433E-006 Cofactor metabolism M143 4.4641E-006 4.46411E-006 5.06829E-006 5.0683E-006 3.52892E-006 3.52893E-006 1.67433E-006 1.67433E-006 Cofactor metabolism M144 4.4641E-006 4.46411E-006 5.06829E-006 5.0683E-006 3.52892E-006 3.52893E-006 1.67433E-006 1.67433E-006 Cofactor metabolism M145 0.000004598 0.000004598 5.22034E-006 5.22035E-006 3.63479E-006 3.63479E-006 1.72456E-006 1.72456E-006 CoA metabolism M146 0.000004598 5.39445E-006 5.22034E-006 6.29491E-006 3.63479E-006 4.32766E-006 1.72456E-006 2.13749E-006 CoA metabolism M147 0.000004598 5.39445E-006 5.22034E-006 6.29491E-006 3.63479E-006 4.32766E-006 1.72456E-006 2.13749E-006 CoA metabolism M148 1.33923E-007 9.30344E-007 0.000000152 1.22662E-006 1.05868E-007 7.98737E-007 5.02298E-008 4.63165E-007 CoA metabolism M149 0 7.96421E-007 0 1.07457E-006 0 6.92869E-007 0 4.12935E-007 CoA metabolism M150 0 9.30344E-007 0 1.22662E-006 0 7.98737E-007 0 4.63165E-007 CoA metabolism M151 0.01891619 0.01891621 0.02147639 0.02147641 0.01495346 0.01495347 0.00709479 0.0070948 CoA metabolism M152 0 0.01219639 0 0.01384779 0 0.00964164 0 0.00457489 Amino acid metabolism M153 0.00591499 0.0181114 0.0059121 0.01975991 0.00591815 0.01555981 0.00592473 0.01049963 Amino acid metabolism M154 0.0063926 0.00639261 0.00697447 0.00697448 0.00549196 0.00549197 0.00370588 0.00370588 Amino acid metabolism M155 0.02343864 0.02343866 0.02557205 0.02557208 0.0201365 0.02013652 0.01358788 0.0135879 Amino acid metabolism M156 0.02663427 0.02663429 0.02905852 0.02905856 0.02288195 0.02288197 0.01544057 0.01544059 Amino acid metabolism M157 0.03089658 0.03089661 0.03370883 0.03370887 0.02654372 0.02654375 0.01791137 0.01791139 Amino acid metabolism M158 0.00319603 0.00319603 0.00348693 0.00348694 0.00274577 0.00274577 0.00185284 0.00185284 Amino acid metabolism M159 0.02343904 0.02343906 0.0255725 0.02557254 0.02013681 0.02013683 0.01358803 0.01358805 Amino acid metabolism M160 0.01811138 0.0181114 0.01975989 0.01975991 0.01555979 0.01555981 0.01049962 0.01049963 Amino acid metabolism M161 0.01384974 0.01384975 0.01511034 0.01511036 0.01189855 0.01189856 0.00802907 0.00802907 Amino acid metabolism M162 0.01065344 0.01065345 0.0116231 0.01162312 0.00915257 0.00915258 0.00617613 0.00617613 Amino acid metabolism M163 0.00319603 0.00319603 0.00348693 0.00348694 0.00274577 0.00274577 0.00185284 0.00185284 Amino acid metabolism M164 0.02237289 0.02237291 0.02440928 0.02440931 0.01922092 0.01922094 0.01297012 0.01297013 Amino acid metabolism M165 0.02237235 0.02237238 0.02440867 0.0244087 0.0192205 0.01922052 0.01296992 0.01296993 Amino acid metabolism M166 0.01491495 0.01491496 0.0162725 0.01627252 0.0128137 0.01281371 0.00864663 0.00864664 Amino acid metabolism M167 0.01917699 0.01917701 0.0209225 0.02092253 0.01647526 0.01647527 0.01111733 0.01111734 Amino acid metabolism M168 0.02130728 0.0213073 0.02324667 0.0232467 0.01830545 0.01830547 0.01235241 0.01235242 Amino acid metabolism M169 0.03409248 0.03409251 0.03719561 0.03719566 0.02928938 0.02928941 0.01976416 0.01976418 Amino acid metabolism M170 0.0063922 0.0063922 0.00697402 0.00697402 0.00549165 0.00549165 0.00370573 0.00370573 Amino acid metabolism M171 0.01598083 0.01598084 0.01743542 0.01743544 0.01372938 0.0137294 0.00926444 0.00926445 Amino acid metabolism M172 0.02876482 0.02876485 0.03138299 0.03138303 0.02471236 0.02471238 0.01667575 0.01667576 Amino acid metabolism M173 0.02237235 0.02237238 0.02440867 0.0244087 0.0192205 0.01922052 0.01296992 0.01296993 Amino acid metabolism M174 0.007741 0.00774101 0.007741 0.00774101 0.007741 0.00774101 0.007741 0.00774101 Nucleotide metabolism M175 -7.68517663 -7.68517424 -7.17148935 -7.17148612 -4.86251432 -4.86251224 -2.92475873 -2.92475687 Cofactor metabolism M176 0 1.67668E-007 0 2.26225E-007 0 1.45867E-007 0 4.64552E-007 Nucleotide metabolism M177 0 1.80322E-007 0 2.43299E-007 0 1.56876E-007 0 7.43283E-007 Nucleotide metabolism M178 3.1666501 3.16665488 8.39738239 8.39738883 15.6052463 15.60525045 23.18447645 23.18447892 Pyruvate metabolism M179 7.68877019 7.68877258 7.28786747 7.2878707 5.09592789 5.09592997 3.29290424 3.29290753 Cofactor metabolism M180 4.46E-06 4.46E-06 5.06829E-006 5.0683E-006 3.53E-06 3.53E-06 1.67E-06 1.67E-06 Cofactor metabolism M181 0.00164605 0.00164625 0.00186883 0.00186911 0.00130122 0.0013014 0.00071189 0.00071721 Nucleotide metabolism M182 0 2.06639E-009 0 2.78807E-009 0 1.79771E-009 0 2.14667E-009 Amino acid metabolism M183 0.00409345 0.00409349 0.00464747 0.00464753 0.00323592 0.00323595 0.00153531 0.00153535 Nucleotide metabolism M184 -0.24595991 -0.24595752 -0.35771181 -0.35770858 -0.47737927 -0.47737719 -0.6153326 -0.61533136 Cofactor metabolism M185 4.4641E-006 4.46411E-006 5.06829E-006 5.0683E-006 3.52892E-006 3.52893E-006 1.67433E-006 1.67433E-006 Cofactor metabolism M186 4.4641E-006 4.46411E-006 5.06829E-006 5.0683E-006 3.52892E-006 3.52893E-006 1.67433E-006 1.67433E-006 One carbon pool by folate M187 0.01891619 0.01891621 0.02147639 0.02147641 0.01495346 0.01495347 0.00709479 0.0070948 CoA metabolism M188 -7.54080677 -7.5407996 -7.05384973 -7.05384006 -4.47457715 -4.47457092 -2.21498267 -2.21497833 Cofactor metabolism M189 0.00528605 0.00528645 0.0060487 0.00604924 0.00410559 0.00410593 0.0018643 0.0018645 Nucleotide metabolism M190 0.00032437 0.00032458 0.0004155 0.00041578 0.00018333 0.00018351 3.34865E-006 3.4556E-006 Cofactor metabolism M191 0.000004598 0.000004598 5.22034E-006 5.22035E-006 3.63479E-006 3.63479E-006 1.72456E-006 1.72456E-006 CoA metabolism M192 0.01856537 0.01856875 0.02103083 0.02103539 0.01474921 0.01475215 0.00718009 0.00718298 One carbon pool by folate M193 0.00436482 0.00436801 0.00495558 0.00495987 0.00345044 0.00345321 0.00163709 0.00163874 Amino acid metabolism M194 0.48536233 0.48536711 0.48333295 0.4833394 0.48850147 0.48850563 0.49462755 0.49463009 Cofactor metabolism M195 4.4641E-006 4.46411E-006 5.06829E-006 5.0683E-006 3.52892E-006 3.52893E-006 1.67433E-006 1.67433E-006 Cofactor metabolism M196 4.4641E-006 4.46411E-006 5.06829E-006 5.0683E-006 3.52892E-006 3.52893E-006 1.67433E-006 1.67433E-006 Lipid metabolism M197 0.24050889 0.24051128 0.23922381 0.23922704 0.24249698 0.24249906 0.24643988 0.24644112 Amino acid metabolism M198 7.44359761 7.4436 6.93109678 6.9311 4.61909792 4.6191 2.67769876 2.6777 Pyruvate metabolism M199 0 0 0 0 0 0 0 0 Lipid metabolism M200 0 3.18569E-006 0 4.29828E-006 0 2.77148E-006 0 1.65174E-006 Amino acid metabolism M201 0 3.18569E-006 0 4.29828E-006 0 2.77148E-006 0 1.65174E-006 Amino acid metabolism M202 0 3.18569E-006 0 4.29828E-006 0 2.77148E-006 0 1.65174E-006 Amino acid metabolism M203 0 3.18569E-006 0 4.29828E-006 0 2.77148E-006 0 1.65174E-006 Amino acid metabolism M204 0 3.18569E-006 0 4.29828E-006 0 2.77148E-006 0 1.65174E-006 Amino acid metabolism M205 0 3.18569E-006 0 4.29828E-006 0 2.77148E-006 0 1.65174E-006 Amino acid metabolism M206 0 3.18569E-006 0 4.29828E-006 0 2.77148E-006 0 1.65174E-006 Amino acid metabolism M207 0 3.18569E-006 0 4.29828E-006 0 2.77148E-006 0 1.65174E-006 Amino acid metabolism M208 0 3.18569E-006 0 4.29828E-006 0 2.77148E-006 0 1.65174E-006 Amino acid metabolism M209 0 3.18569E-006 0 4.29828E-006 0 2.77148E-006 0 1.65174E-006 Amino acid metabolism M210 0 3.18569E-006 0 4.29828E-006 0 2.77148E-006 0 1.65174E-006 Amino acid metabolism M211 0 3.18569E-006 0 4.29828E-006 0 2.77148E-006 0 1.65174E-006 Amino acid metabolism M212 0 3.18569E-006 0 4.29828E-006 0 2.77148E-006 0 1.65174E-006 Amino acid metabolism M213 0 3.18569E-006 0 4.29828E-006 0 2.77148E-006 0 1.65174E-006 Amino acid metabolism M214 0 3.18569E-006 0 4.29828E-006 0 2.77148E-006 0 1.65174E-006 Amino acid metabolism M215 0 3.18569E-006 0 4.29828E-006 0 2.77148E-006 0 1.65174E-006 Amino acid metabolism M216 0 3.18569E-006 0 4.29828E-006 0 2.77148E-006 0 1.65174E-006 Amino acid metabolism M217 0 3.18569E-006 0 4.29828E-006 0 2.77148E-006 0 1.65174E-006 Amino acid metabolism M218 0 3.18569E-006 0 4.29828E-006 0 2.77148E-006 0 1.65174E-006 Amino acid metabolism M219 0 3.18569E-006 0 4.29828E-006 0 2.77148E-006 0 1.65174E-006 Amino acid metabolism M220 0.00616954 0.00616985 0.00700451 0.00700493 0.00487707 0.00487734 0.00221422 0.00221953 Nucleotide metabolism M221 0.00948872 0.0094919 0.01077296 0.01077726 0.00750094 0.00750371 0.00355888 0.00356053 Amino acid metabolism M222 0.00111637 0.01331594 0.00126678 0.01511886 0.00088225 0.01052665 0.00041825 0.0049948 Amino acid metabolism M223 0.00215232 0.00215551 0.00244363 0.00244793 0.00170143 0.00170421 0.00080726 0.00080891 Amino acid metabolism M224 0.01659584 0.02879223 0.01884199 0.03268978 0.01311919 0.02276083 0.00622451 0.01079941 Amino acid metabolism M225 0.01208035 0.0120836 0.01376257 0.01376695 0.00947655 0.00947938 0.00431283 0.00431455 Amino acid metabolism M226 0.01584578 0.01584896 0.01799042 0.01799471 0.01252626 0.01252903 0.00594319 0.00594484 Amino acid metabolism M227 0.01978307 0.01978626 0.0224606 0.0224649 0.01563874 0.01564151 0.00741993 0.00742158 Amino acid metabolism M228 0.01433169 0.02652808 0.0162714 0.03011919 0.01132936 0.02097099 0.00537531 0.0099502 Amino acid metabolism M229 0.02172991 0.0217331 0.02467093 0.02467523 0.01717774 0.01718051 0.00815012 0.00815177 Amino acid metabolism M230 0 0.01219639 0 0.01384779 0 0.00964164 0 0.00457489 Amino acid metabolism M231 0.00440692 0.0044101 0.00500337 0.00500767 0.00348372 0.00348649 0.00165288 0.00165453 Amino acid metabolism M232 0.0230054 0.02300858 0.02611905 0.02612335 0.01818602 0.01818879 0.00862851 0.00863016 Amino acid metabolism M233 0.01033556 0.01033874 0.01173442 0.01173872 0.00817037 0.00817314 0.0038765 0.00387815 Amino acid metabolism M234 0.01097598 0.01097916 0.01246152 0.01246581 0.00867663 0.0086794 0.0041167 0.00411835 Amino acid metabolism M235 0.01515657 0.01515975 0.01720792 0.01721222 0.01198143 0.0119842 0.00568469 0.00568634 Amino acid metabolism M236 0.00223254 0.00223573 0.0025347 0.002539 0.00176485 0.00176762 0.00083735 0.000839 Amino acid metabolism M237 0.00722542 0.0072286 0.00820334 0.00820764 0.00571177 0.00571454 0.00271 0.00271165 Amino acid metabolism M238 0.01803645 0.01803963 0.02047758 0.02048188 0.01425801 0.01426078 0.00676483 0.00676649 Amino acid metabolism M239 0 2.38926E-006 0 3.22371E-006 0 2.07861E-006 0 1.2388E-006 Cofactor metabolism M240 0.09423178 0.09423656 0.14607465 0.1460811 0.21618297 0.21618713 0.29723847 0.29724095 Cofactor metabolism M241 3.1666501 3.16665488 8.39738239 8.39738883 15.6052463 15.60525045 23.18447645 23.18447892 sink/source M242 0 2.06639E-009 0 2.78807E-009 0 1.79771E-009 0 2.14667E-009 sink/source M243 7.44359761 7.4436 6.93109678 6.9311 4.61909792 4.6191 2.67769876 2.6777 sink/source M244 -0.00528645 -0.00528605 -0.00604924 -0.0060487 -0.00410593 -0.00410559 -0.0018645 -0.0018643 sink/source M245 0 4.03523E-007 0 0.000000532 0 3.4644E-007 0 2.00891E-007 sink/source M246 0.04464103 0.04464107 0.05068294 0.05068299 0.03528922 0.03528926 0.01674327 0.01674329 sink/source M247 7.68517424 7.68517663 7.17148612 7.17148935 4.86251224 4.86251432 2.92475687 2.92475873 sink/source M248 -0.0120806 -0.01208035 -0.01376291 -0.01376257 -0.00947677 -0.00947655 -0.00431413 -0.00431283 sink/source M249 0.24595752 0.24595991 0.35770858 0.35771181 0.47737719 0.47737927 0.61533136 0.6153326 sink/source M250 -0.01978309 -0.01978307 -0.02246062 -0.0224606 -0.01563875 -0.01563874 -0.00741994 -0.00741993 sink/source M251 -0.25 -0.24999761 -0.25 -0.24999678 -0.25 -0.24999792 -0.25 -0.24999876 sink/source M252 -0.02652808 -0.01433169 -0.03011919 -0.0162714 -0.02097099 -0.01132936 -0.0099502 -0.00537531 sink/source M253 -0.01331277 -0.00111637 -0.01511458 -0.00126678 -0.01052389 -0.00088225 -0.00499315 -0.00041825 sink/source M254 -0.00215232 -0.00215232 -0.00244363 -0.00244363 -0.00170144 -0.00170143 -0.00080726 -0.00080726 sink/source M255 -0.02879223 -0.01659584 -0.03268978 -0.01884199 -0.02276083 -0.01311919 -0.01079941 -0.00622451 sink/source M256 -0.01219322 3.18569E-006 -0.0138435 4.29828E-006 -0.00963887 2.77148E-006 -0.00457325 1.65174E-006 sink/source M257 -0.00440692 -0.00440692 -0.00500337 -0.00500337 -0.00348372 -0.00348372 -0.00165288 -0.00165288 sink/source M258 0 2.06639E-009 0 2.78807E-009 0 1.79771E-009 0 2.14667E-009 sink/source M259 -0.01584579 -0.01584578 -0.01799044 -0.01799042 -0.01252628 -0.01252626 -0.0059432 -0.00594319 sink/source M260 -0.02172993 -0.02172991 -0.02467096 -0.02467093 -0.01717775 -0.01717774 -0.00815013 -0.00815012 sink/source M261 -0.02300542 -0.0230054 -0.02611908 -0.02611905 -0.01818604 -0.01818602 -0.00862852 -0.00862851 sink/source M262 -0.00436482 -0.00436482 -0.00495558 -0.00495558 -0.00345044 -0.00345044 -0.00163709 -0.00163709 sink/source M263 0.24050889 0.24051128 0.23922381 0.23922704 0.24249698 0.24249906 0.24643988 0.24644112 sink/source M264 -0.01097599 -0.01097598 -0.01246153 -0.01246152 -0.00867664 -0.00867663 -0.00411671 -0.0041167 sink/source M265 -0.01033557 -0.01033556 -0.01173443 -0.01173442 -0.00817038 -0.00817037 -0.00387651 -0.0038765 sink/source M266 -0.01856563 -0.01856537 -0.02103117 -0.02103083 -0.01474943 -0.01474921 -0.00718139 -0.00718009 sink/source M267 -0.01515658 -0.01515657 -0.01720794 -0.01720792 -0.01198144 -0.01198143 -0.0056847 -0.00568469 sink/source M268 -0.00223254 -0.00223254 -0.00253471 -0.0025347 -0.00176485 -0.00176485 -0.00083735 -0.00083735 sink/source M269 -0.00722542 -0.00722542 -0.00820335 -0.00820334 -0.00571178 -0.00571177 -0.00271 -0.00271 sink/source M270 -0.01803646 -0.01803645 -0.0204776 -0.02047758 -0.01425803 -0.01425801 -0.00676484 -0.00676483 sink/source M271 0.00031545 0.00031565 0.00040536 0.00040564 0.00017627 0.00017645 0 1.06947E-007 sink/source M272 0.48536233 0.48536711 0.48333295 0.4833394 0.48850147 0.48850563 0.49462755 0.49463009 sink/source M273 0 0 0 0 0 0 0 0 sink/source M274 -4.46411E-006 -4.4641E-006 -5.0683E-006 -5.06829E-006 -3.52893E-006 -3.52892E-006 -1.67433E-006 -1.67433E-006 sink/source M275 0.00164605 0.00164625 0.00186883 0.00186911 0.00130122 0.0013014 0.00071189 0.00071721 sink/source M276 0.00616954 0.00616985 0.00700451 0.00700493 0.00487707 0.00487734 0.00221422 0.00221953 sink/source M277 0 0 0 0 0 0 0 0 sink/source M278 0 0 0 0 0 0 0 0 sink/source M279 0.12770757 0.127709 0.18422307 0.184225 0.24242675 0.242428 0.30943926 0.30944 sink/source M280 0.01891619 0.01891621 0.02147639 0.02147641 0.01495346 0.01495347 0.00709479 0.0070948 sink/source M281 4.4641E-006 4.46411E-006 5.06829E-006 5.0683E-006 3.52892E-006 3.52893E-006 1.67433E-006 1.67433E-006 sink/source M282 5.10835881 5.10836 7.36899839 7.369 9.69713896 9.69714 12.37759938 12.3776 sink/source M283 0.12770661 0.127709 0.18422178 0.184225 0.24242592 0.242428 0.30943876 0.30944 sink/source M284 0.00409345 0.00409349 0.00464747 0.00464753 0.00323592 0.00323595 0.00153531 0.00153535 sink/source M285 -10.22381519 -10.2238128 -14.90589598 -14.90589276 -19.89386839 -19.89386631 -25.64227075 -25.64226889 sink/source M286 0 0 0 0 0 0 0 0 sink/source M287 0.00032437 0.00032458 0.0004155 0.00041578 0.00018333 0.00018351 3.34865E-006 3.4556E-006 sink/source M288 0.09423178 0.09423417 0.14607465 0.14607788 0.21618297 0.21618505 0.29723847 0.29723971 sink/source M289 7.68877019 7.68877258 7.28786747 7.2878707 5.09592789 5.09592997 3.29290424 3.29290753 sink/source M290 0.000004598 0.000004598 5.22034E-006 5.22035E-006 3.63479E-006 3.63479E-006 1.72456E-006 1.72456E-006 sink/source M291 0 0 0 0 0 0 0 0 sink/source M292 4.4641E-006 4.46411E-006 5.06829E-006 5.0683E-006 3.52892E-006 3.52893E-006 1.67433E-006 1.67433E-006 sink/source M293 4.4641E-006 4.46411E-006 5.06829E-006 5.0683E-006 3.52892E-006 3.52893E-006 1.67433E-006 1.67433E-006 sink/source M294 0.12770661 0.127709 0.18422178 0.184225 0.24242592 0.242428 0.30943876 0.30944 sink/source M295 4.4641E-006 4.46411E-006 5.06829E-006 5.0683E-006 3.52892E-006 3.52893E-006 1.67433E-006 1.67433E-006 sink/source M296 0 1.80322E-007 0 2.43299E-007 0 1.56876E-007 0 7.43283E-007 sink/source M297 0 1.67668E-007 0 2.26225E-007 0 1.45867E-007 0 4.64552E-007 sink/source M298 -7.54080677 -7.5407996 -7.05384973 -7.05384006 -4.47457715 -4.47457092 -2.21498267 -2.21497833 sink/source M299 0.00106534 0.00106534 0.00116231 0.00116231 0.00091526 0.00091526 0.00061761 0.00061761 Protein metabolism M300 0 0 0 0 0 0 0 0 Protein metabolism M301 0 0 0 0 0 0 0 0 Protein metabolism M302 0.0003489 0.0003489 0.0003489 0.0003489 0.0003489 0.0003489 0.0003489 0.0003489 Protein metabolism M303 1.33923E-007 1.33923E-007 0.000000152 0.000000152 1.05868E-007 1.05868E-007 5.02298E-008 5.02299E-008 Protein metabolism M304 13.1031 13.10310239 16.9595 16.95950322 20.4334 20.43340208 25.2013 25.20130124 Energy metabolism M305 4.4641E-008 4.46411E-008 5.06829E-008 5.0683E-008 3.52892E-008 3.52893E-008 1.67433E-008 1.67433E-008 Biomass production M306 0.04464103 0.04464107 0.05068294 0.05068299 0.03528922 0.03528926 0.01674327 0.01674329 Biomass production Table S10: Flux Variability Analysis (FVA): Reaction fluxes in mmol*g-1*h-1 showing variability > 0.00001 are highlighted in orange, reactions that can vary between no flux and flux in yellow.