Table S5: Constraints										
	24h		36h		48h		60h		defined medium	
reaction ID	min	max	min	max	min	max	min	max	min	max
M048	0.01	inf	0.01	inf	0.01	inf	0.01	inf	0.01	inf
M130	0.01	inf	0.01	inf	0.01	inf	0.01	inf	0.01	inf
M302	0.0003489	inf	0.0003489	inf	0.0003489	inf	0.0003489	inf	0.0003489	inf
M174	0.007741	inf	0.007741	inf	0.007741	inf	0.007741	inf	0.007741	inf
M251	0	0.25	0	0.25	0	0.25	0	0.25	0	0.25
M273	0	0	0	0	0	0	0	0	0	0
M277	0	0	0	0	0	0	0	0	0	0
M278	0	0	0	0	0	0	0	0	0	0
M279	0	0.1277089592	0	0.1842251049	0	0.242428403	0	0.3094402185	0	0
M282	0	5.1083583676	0	7.369004196	0	9.6971361183	0	12.3776087416	0	7.369004196
M283	0	0.1277089592	0	0.1842251049	0	0.242428403	0	0.3094402185	0	0.1842251049
M286	0	0	0	0	0	0	0	0	0	0
M291	0	0	0	0	0	0	0	0	0	0
M294	0	0.1277089592	0	0.1842251049	0	0.242428403	0	0.3094402185	0	0.1842251049
M243	0	7.4436	0	6.9311	0	4.6191	0	2.6777	0	6.9311
M304	13.105	inf	16.9625	inf	20.435	inf	25.2015	inf	-	-
										
Table S5: Constraints: Final constraints in mmol*g-1*h-1 as used for simulating growth of M. pneumoniae at different time points of the exponential growth phase under rich medium conditions and to simulate growth on defined medium. Glucose and acetate have been constrained as for the 36-hour time point under rich medium conditions (for details see SI).