MyMpn
The Mycoplasma pneumoniae database
 
e.g Mpn001 or dnaN or polymerase
Gene dnaE (MPN378)
Name 
dnaE
Stable ID 
MPN378
Location 
453650 - 456268 +
Sequence 
    1  ATGTTTGTTA ACCTCCACAC TAACTCTTAC TATAACTTCC TCAACTCCAC ACTTTCACCG
   61  CAAAAGCTAG TTGACCTAGC TGTTCAAGAC CAACAGGTAG CTGTTTGTTT AACCGATCCC
  121  AACTTATTTG GTGCTACCGA GTTTTTTTTG GCCTGTCAAA AAGCGCACAT TAAACCCTTA
  181  ATTGGGTTGA GTGTTACTGT TCGACATTAC GAACAAAACG TTAATTTACT AGTAATTGCC
  241  CAAACCAACC GGGGTTATCA GAACCTAATG TGCTTAGCGT TAGTTAAAGA CCAACCAGAT
  301  TTGCAATTAG AACCCTTTTT GGATGGTAAT GTGGTAATTA TTTGCACACA AACTGAACTG
  361  CGCCTCAACA CCGCAAACCC CGTTTACTTA GCACATGGTT TGAGTGGTCG TTATCCTAAA
  421  ATTGCAGTAA CACAAAAACC AGTTAAGTGT CAAAACACCA ATAAGGACTT AACACTGCTC
  481  TTAACACTTA AGCAAATTAG TCAAATTAAC AGCGAACACT TCCAGCCACT GGAATGAAAA
  541  TTAAGCCGTA GTTTAAACGA AATCCAATTG GATCCACCAT TGTTGCAACA ACTCCGGCAC
  601  CAACCTTTTT TAAGCCAAAA GGCAGCACAG CAAATTTTTA GCGAAGAGGA ATTGGGAAAT
  661  CTGCAAAAGC TAGTGGAGCA AAGTCAATGA GATTTAACCA AACTCAAAGC GTCATCGTTA
  721  CAAGTGTCAC ACAACGATGC ACAAATGTTA AGCGAGCAGT GTCAACTAGC CTTAACTGAA
  781  TTTTTAAAGC TCAATCCGCA ATTAAACAAA CAGCTCTATG AAGAGCGGTT AGCCAAAGAA
  841  TTGGAGATAA TTAACTCACT CCACTTTGCT AGTTACTTTT TAGTGGTGAG CGACTTAGTT
  901  CAGTTTGCCC ATAATAACGA TATCCTCATC GGTCCTGGTC GAGGATCTGC AGTGGGTTCT
  961  TTAGTGGCCT TTCTGCTCAA AATTACCCAA ATTGATCCAG TAGCCAACAA TCTCATTTTT
 1021  GAGCGCTTTA TTTCCCGTCA CCGCCAGGGC TTACCTGACA TTGACATTGA CATTATGGAA
 1081  ACTAAACGTG ATTTAGTAAT TGACTATGTC ATGCAAAAAT ATGGCCGGGA ACAGTGTGCA
 1141  CAAATAGTTA CTTTCCAAAA ATTTAAGACC CGCTCTGCGT TGCGTGATGT CGGTAAGGTA
 1201  TTTAACCACA TTGAGGGTGC TGAAGATTTA CTGGGTAAAC TACCAAAAGA CAAAAGCTTA
 1261  TTGGAGCTTG ATGTAAACGG TGTTACTGAT CCGGTTTTAC AACTTAGTTT AAAGAGCTTT
 1321  CGCTTGTTGT GGGAGGTGGC GCGTGAAATT ATTAACTTTC CGCGCCAACC AAGCATTCAC
 1381  GCTTCTGGTG TTGTGATTGT CACTGAACCT TTAATTACCA CGATCCCTTT AATGGTGGGT
 1441  AATAACAACA ACTACGTCAC CCAAGTGTCG ATGGACTGGT TAGAATGGTA CAACCTCAAT
 1501  AAGTTTGACT TATTGGGTTT AATTAACCTC ACCATGATCC ATGAGGTTGT GCAAGCGGTA
 1561  AAACCCAAGG AAGTTAGCGT ACAGCAATTC CTCCAACAAA TACCGCTAGA TGATGAAGCT
 1621  ACTTTTACTA ACCTCACTAA CCAAGCCACT TTAGGTGTTT TTCAACTAGA GTCGTTTGGG
 1681  ATGAAAAAGG TGCTCAAACA AATTAAACCG CACAACCTCC ATGATTTAGC AATTGTTTTA
 1741  GCACTTTACC GCCCCGGTCC ACAGGACAAC ATTAATACCT TTATTGCTAA CCGTAACTTA
 1801  GGGTTTGACA CATCAGACAT CGATCCGCGA ATTTTGCCAA TCCTCAAAGA AACTTACGGA
 1861  GTGTTAATCT TTCAAGAACA GGTTATTAAC ATCGCCAAAA CTGTTGCTAA CTATTCATTG
 1921  GAAACCGCTG ATAGCTTTCG CCGTGCCATT TCCAAAAAAA ACTTGCAAGT AATTCAGGAC
 1981  AACATGCGCA GCTTTTATGA AGGCGCGCTA GCCAATAACT TTAGCTTAAA AGCAGCGACT
 2041  ACTATCTTTA ATTACATCCA GCGCTTTGCT GGATATGGTT TTAACTTGTC CCACGCCTTG
 2101  GGCTATGCTT TATTGAGTTA CTGAACAGCA TGATTGAAGA CACATTACTT TGAGCAATTT
 2161  AACCTGTGGT GATTAAACCA CGAACAGGGC AAAAAGGAAA AGCAAAAACA GCTCTTAAAC
 2221  GAGTTTATTA GCAGTGGTTA TGAAATTTGC CCACCACTAA TCAATAAGGC TAAAAGTGAT
 2281  TTTAGTGTTC AAGATAAAAA GCTGTATTTA GGCTTTAAGT TAATCAATGG TATTGGTGAC
 2341  AAGCAAGCCC ATGCCTTGGA ACATGTTCAG GAAGTTTTAA AGCAAAACCC CAATTTATCC
 2401  TTAATAGCTA CCGTTAATTT GTGTTTGAGC AAAACGGTAG GGGGTTTAGA ACTTAAAGAC
 2461  ATTACATTGC TCCAACAAGC AGGTTGTTTT AATTGCTTTA ATTACACGGT TGACTTTAAT
 2521  TTGGCCAAAA GCTTTTGGGT GCAAAGTAAC CATGAATTAT TTCCAAAAAT ACCACTAGAT
 2581  CAACCACCCG TAATTAACTG AAAGAGCTTT GGTTTTTAA
Download Sequence
Operon 
OP152
Operon location 
453392 - 457035
Protein (mpn378)
Name 
DNA polymerase III subunit alpha (EC 2.7.7.7)
Stable ID 
Mpn378
Molecular Weight 
95920
Isoelectric Point 
7
Localization 
Cytoplasm
Comment -
Sequence 
MFVNLHTNSYYNFLNSTLSPQKLVDLAVQDQQVAVCLTDPNLFGATEFFLACQKAHIKPLIGLSVTVRHYEQNVNLLVIA
QTNRGYQNLMCLALVKDQPDLQLEPFLDGNVVIICTQTELRLNTANPVYLAHGLSGRYPKIAVTQKPVKCQNTNKDLTLL
LTLKQISQINSEHFQPLEWKLSRSLNEIQLDPPLLQQLRHQPFLSQKAAQQIFSEEELGNLQKLVEQSQWDLTKLKASSL
QVSHNDAQMLSEQCQLALTEFLKLNPQLNKQLYEERLAKELEIINSLHFASYFLVVSDLVQFAHNNDILIGPGRGSAVGS
LVAFLLKITQIDPVANNLIFERFISRHRQGLPDIDIDIMETKRDLVIDYVMQKYGREQCAQIVTFQKFKTRSALRDVGKV
FNHIEGAEDLLGKLPKDKSLLELDVNGVTDPVLQLSLKSFRLLWEVAREIINFPRQPSIHASGVVIVTEPLITTIPLMVG
NNNNYVTQVSMDWLEWYNLNKFDLLGLINLTMIHEVVQAVKPKEVSVQQFLQQIPLDDEATFTNLTNQATLGVFQLESFG
MKKVLKQIKPHNLHDLAIVLALYRPGPQDNINTFIANRNLGFDTSDIDPRILPILKETYGVLIFQEQVINIAKTVANYSL
ETADSFRRAISKKNLQVIQDNMRSFYEGALANNFSLKAATTIFNYIQRFAGYGFNLSHALGYALLSYWTAWLKTHYFEQF
NLWWLNHEQGKKEKQKQLLNEFISSGYEICPPLINKAKSDFSVQDKKLYLGFKLINGIGDKQAHALEHVQEVLKQNPNLS
LIATVNLCLSKTVGGLELKDITLLQQAGCFNCFNYTVDFNLAKSFWVQSNHELFPKIPLDQPPVINWKSFGF
Post translational modifications
Modification Modified sequence Relative start Relative end Amino acid
Oxidation DLVIDYVmQK 364 374 M
Oxidation NLQVIQDNmR 654 664 M
GENE/PROTEIN dnaE (Domains Overview)
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Domains (InterProScan)
Location (aa) Name (InterPro ID) Description GO terms Sequence Evalue
2-872 TIGR00594 (IPR004805) DNA polymerase III, alpha subunit Biological Process:
<'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0006260'>'DNA' == '' ? '': 'DNA'; 'replication' == '' ? '': 'replication'; ('GO' == '' ? '': 'GO';:0006260)

Cellular Component:
<'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0005737'>'cytoplasm' == '' ? '': 'cytoplasm'; ('GO' == '' ? '': 'GO';:0005737)

Molecular Function:
<'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0008408'>3'-5' 'exonuclease' == '' ? '': 'exonuclease'; 'activity' == '' ? '': 'activity'; ('GO' == '' ? '': 'GO';:0008408)

0
3-69 SM00481 (IPR003141) Polymerase/histidinol phosphatase, N-terminal Biological Process:
<'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0006260'>'DNA' == '' ? '': 'DNA'; 'replication' == '' ? '': 'replication'; ('GO' == '' ? '': 'GO';:0006260)

Molecular Function:
<'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0003677'>'DNA' == '' ? '': 'DNA'; 'binding' == '' ? '': 'binding'; ('GO' == '' ? '': 'GO';:0003677) <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0003887'>'DNA' == '' ? '': 'DNA';-'directed' == '' ? '': 'directed'; 'DNA' == '' ? '': 'DNA'; 'polymerase' == '' ? '': 'polymerase'; 'activity' == '' ? '': 'activity'; ('GO' == '' ? '': 'GO';:0003887)

4.7e-18
3-125 PF02811 (IPR004013) PHP, C-terminal Molecular Function:
<'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0003824'>'catalytic' == '' ? '': 'catalytic'; 'activity' == '' ? '': 'activity'; ('GO' == '' ? '': 'GO';:0003824)

0.0000000031
249-673 PF07733 (IPR011708) Bacterial DNA polymerase III, alpha subunit Biological Process:
<'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0006260'>'DNA' == '' ? '': 'DNA'; 'replication' == '' ? '': 'replication'; ('GO' == '' ? '': 'GO';:0006260)

Cellular Component:
<'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0005737'>'cytoplasm' == '' ? '': 'cytoplasm'; ('GO' == '' ? '': 'GO';:0005737)

Molecular Function:
<'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0008408'>3'-5' 'exonuclease' == '' ? '': 'exonuclease'; 'activity' == '' ? '': 'activity'; ('GO' == '' ? '': 'GO';:0008408)

0
Protein Homology (BLASTP results)
Protein Start Protein End Hit Size Orthologous Organism Orthologous Start Orthologous End Evalue Identity Score Alignment
275 856 581 - MAG1660 Mycoplasma agalactiae 252 834 <1e-50 33.3901 774
2 114 112 - MAG1660 Mycoplasma agalactiae 4 113 0.000004 24.5614 774
273 779 506 - MARTH_orf612 Mycoplasma arthritidis 270 782 <1e-50 39.2308 890
243 796 553 - Caulobacter crescentus NA1000 293 848 <1e-50 35.1064 870
264 862 598 - Caulobacter crescentus NA1000 294 909 <1e-50 28.5714 576
3 779 776 - MCJ_005400 Mycoplasma conjunctivae 4 763 <1e-50 30.2879 794
3 835 832 - MHO_4120 Mycoplasma hominis 4 832 <1e-50 32.0091 966
1 778 777 - Lactococcus lactis subsp. lactis KF147 1 780 <1e-50 30.8075 797
273 797 524 - Bacillus subtilis subsp. subtilis 302 825 <1e-50 39.9621 1008
2 95 93 - Bacillus subtilis subsp. subtilis 3 100 0.00000004 31.6327 1008
273 797 524 - Bacillus subtilis subsp. subtilis 302 825 <1e-50 39.9621 1005
2 95 93 - Bacillus subtilis subsp. subtilis 3 100 0.00000004 31.6327 1005
266 836 570 - Rv3370c Mycobacterium tuberculosis 373 928 <1e-50 31.9516 706
260 831 571 - b0184 Escherichia coli 313 889 <1e-50 34.4123 873
196 716 520 - MG031 Mycoplasma genitalium 783 1297 0.000006 19.5502 102
243 779 536 - Rv1547 Mycobacterium tuberculosis 314 868 <1e-50 33.6315 812
42 835 793 - MCAP_0637 Mycoplasma capricolum subsp. capricolum 45 823 <1e-50 31.2195 907
1 867 866 - MG261 Mycoplasma genitalium 1 867 <1e-50 54.2529 2403
194 833 639 - MS53_0529 Mycoplasma synoviae 171 814 <1e-50 32.8767 753
267 779 512 - MHP7448_0582 Mycoplasma hyopneumoniae 7448 252 774 <1e-50 33.5863 760
3 115 112 - MHP7448_0582 Mycoplasma hyopneumoniae 7448 4 114 0.0000002 28.6957 760
3 808 805 - MMOB4870 Mycoplasma mobile 5 792 <1e-50 32.2929 931
42 835 793 - MSC_0684 Mycoplasma mycoides subsp. mycoides SC 45 824 <1e-50 30.5521 909
260 836 576 - LIC_10222 Leptospira interrogans serovar Copenhage 314 891 <1e-50 31.9185 799
1 786 785 - MYCGA2320 Mycoplasma gallisepticum 1 788 <1e-50 35.6532 1180
36 833 797 - MYPE1980 Mycoplasma penetrans 47 824 <1e-50 33.6207 1023
274 716 442 - Mycoplasma pulmonis 253 696 <1e-50 35.3579 734
2 93 91 - Mycoplasma pulmonis 4 91 0.00000000005 32.6087 734
External IDs
COG 
COG0587L
EC number 
2.7.7.7
Gene ID 
876812
GI 
13508117
GO 
DNA replication, recombination and repair
Home COG 
L
InterPro 
IPR004805|DNA polymerase III, alpha subunit
InterPro 
IPR011708|Bacterial DNA polymerase III, alpha subunit
InterPro 
IPR004013|PHP, C-terminal
InterPro 
IPR003141|Polymerase and histidinol phosphatase, N-terminal
Old MP number 
MP459
Pathway 
Division, DNA maintenance
PDB homologs 
1m65_A
PDB homologs 
1m68_A
PDB homologs 
1pb0_A
Pfam 
PF07733
Pfam 
PF02811
PID 
g1674148
RefSeq 
NP_110066.1
Swiss-Prot protein ID 
DPO3A_MYCPN
phylomeDB tree 
DPO3A_MYCPN
UniProt 
P75404
Transcription
IMAGE BROWSERS

OPERON OP152 (Genomic Overview)
Region:453392-457035

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STRING image

STRING of Mpn378STRING legend

PDB image(s)

1m65

PDB 1m65

1m68

PDB 1m68

1pb0

PDB 1pb0
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