MyMpn Project

Name	disA
Stable ID	MPN244
Location	296561 - 297169 +
Sequence	1 ATGATGACAG TGGAAGTCTT TTCGGTTATT ATCCTTGTCC TTTTATTCTT AATCTTAGCG 61 CTTACCTTGT TGTTTGTTTT ACTCAACAAG CGTACTAGAA GCTTTGTTAT TCGTACCTTT 121 ACTGGATTAT TTAGATCAAA GCATACTACC AGTCAAAAGA ACTTTTATGA CAACTTGACC 181 TCAACCTTAC TGAGGTTATC AACTGATAAG ATTGGTGCCA TTATTGCCAT TGAAAACCAG 241 GACTCACTCG AGTCTTACGT CAATATTGGC TACCGCGTGA CTTCGGACTT TTCCCCCGAG 301 TTGTTAGTAA CGATCTTTTA CAACAAGCAG TCGCCACTTC ACGATGGAGC GGTAATTGTG 361 CGGGACTACC AGATTGTGAG TGTGTCCTCT TACTTCCCAA TGACACGGCA ACTAATTGAT 421 GTGTCATACG GTTCCAGACA CCGCAGCGCG TTAGGTCTAA CCGAAAAGTG TGATGCCATA 481 GTCTTTATTG TTAGTGAAAC AACAGGCAAA ATTTCGGTGG CTGTGCGCGG CGTGATTAAA 541 ACACTGTCGA GTAACTCCGA CCGTTTACAA GACCAGATTA TTCACTATCT GACGGTAAAG 601 CCGGGTTAA
Download Sequence
Operon	OP99
Operon location	294125 - 297450

MMTVEVFSVIILVLLFLILALTLLFVLLNKRTRSFVIRTFTGLFRSKHTTSQKNFYDNLTSTLLRLSTDKIGAIIAIENQ

DSLESYVNIGYRVTSDFSPELLVTIFYNKQSPLHDGAVIVRDYQIVSVSSYFPMTRQLIDVSYGSRHRSALGLTEKCDAI

VFIVSETTGKISVAVRGVIKTLSSNSDRLQDQIIHYLTVKPG

Name	DNA integrity scanning protein DisA
Stable ID	Mpn244
Molecular Weight	22220
Isoelectric Point	10
Localization	SIGNALP
Comment	DisA N terminus domain. The DisA protein is a bacterial checkpoint protein that dimerises into an octameric complex. The protein consists of three distinct domains. This domain is the first and is a globular, nucleotide-binding region. Di-adenylate cyclase activity, second messenger candidate in Bacteria and Archaea (Sci Signal, 2008,1:39). Before, DUF147
Sequence	MMTVEVFSVIILVLLFLILALTLLFVLLNKRTRSFVIRTFTGLFRSKHTTSQKNFYDNLTSTLLRLSTDKIGAIIAIENQ DSLESYVNIGYRVTSDFSPELLVTIFYNKQSPLHDGAVIVRDYQIVSVSSYFPMTRQLIDVSYGSRHRSALGLTEKCDAI VFIVSETTGKISVAVRGVIKTLSSNSDRLQDQIIHYLTVKPG

Modification	Modified sequence	Relative start	Relative end	Amino acid
Oxidation	DYQIVSVSSYFPmTR	122	137	M

Location (aa)	Name (InterPro ID)	Description	GO terms	Sequence	Evalue
1-200	TIGR00159 (IPR014046)	Conserved hypothetical protein CHP00159			0
2-184	SSF143597 (n.a.)	NULL			1.7e-39
2-201	PIRSF004793 (IPR014046)	Conserved hypothetical protein CHP00159			0
55-180	G3DSA:3.40.1700.10 (n.a.)	NULL			1.3e-38
61-179	PF02457 (IPR003390)	DNA integrity scanning protein, DisA, N-terminal			3.3e-32

Protein Start	Protein End	Hit Size	Orthologous	Organism	Orthologous Start	Orthologous End	Evalue	Identity	Score	Alignment
50	197	147	- MAG3060	Mycoplasma agalactiae	46	190	7e-29	40.5405	295
59	191	132	- MARTH_orf527	Mycoplasma arthritidis	57	186	9e-25	42.8571	259
44	177	133	- MCJ_002940	Mycoplasma conjunctivae	10	142	2e-22	38.0597	240
59	177	118	- MHO_0510	Mycoplasma hominis	13	130	4e-26	43.6975	271
66	177	111	-	Lactococcus lactis subsp. lactis KF147	136	247	1e-24	46.9027	263
58	184	126	-	Bacillus subtilis subsp. subtilis	76	201	5e-23	40.1575	252
42	177	135	-	Bacillus subtilis subsp. subtilis	104	243	5e-20	34.7518	226
42	177	135	-	Bacillus subtilis subsp. subtilis	95	234	6e-20	34.7518	226
58	184	126	-	Bacillus subtilis subsp. subtilis	76	201	4e-23	40.1575	253
29	200	171	- MG105	Mycoplasma genitalium	28	200	<1e-50	81.5029	751
44	198	154	- MS53_0498	Mycoplasma synoviae	61	212	6e-25	35.4839	261
29	173	144	- MHP7448_0488	Mycoplasma hyopneumoniae 7448	36	170	3e-20	36.5517	221
35	199	164	- MMOB4550	Mycoplasma mobile	50	216	8e-29	38.2353	294
66	177	111	- LIC_10844	Leptospira interrogans serovar Copenhage	124	234	1e-20	41.0714	230
51	200	149	- MYCGA4570	Mycoplasma gallisepticum	55	204	<1e-50	63.3333	501
52	193	141	- MYPE2120	Mycoplasma penetrans	52	193	8e-33	42.2535	331
65	197	132	-	Mycoplasma pulmonis	77	206	2e-25	38.3459	266

EC number	4.6.1.-
Gene ID	876807
GI	13507983
GO	DNA replication, recombination and repair/ Division and chromosome partitioning
Home COG	LD
InterPro	IPR003390\|DAC (diadenylate cyclase)
Old MP number	MP588
Pathway	Membrane, ABC transporter?
PDB homologs	2FB5
Pfam	PF02457
PID	g1674289
RefSeq	NP_109932.1
Swiss-Prot protein ID	Y244_MYCPN
phylomeDB tree	Y244_MYCPN
UniProt	P75528