MyMpn
The Mycoplasma pneumoniae database
 
e.g Mpn001 or dnaN or polymerase
Gene tmk (MPN006)
Name 
tmk
Stable ID 
MPN006
Location 
8579 - 9211 +
Sequence 
    1  ATGAAACAAG GCGTGTTTGT GGCCATAGAG GGCGTGGATG GTGCGGGGAA AACCGTCCTC
   61  CTAGAAGCTT TTAAACAGCG CTTTCCCCAA AGCTTTTTGG GCTTTAAAAC GCTTTTTAGC
  121  AGGGAACCCG GGGGCACACC GTTAGCGGAA AAAATCCGGG CACTGCTCCT GCATGAAGCA
  181  ATGGAACCAC TTACAGAAGC TTATCTGTTT GCGGCATCGC GCACCGAACA CGTGCGCCAG
  241  TTAATCCAAC CAGCGTTACA ACAAAAACAG TTAGTGATAG TAGACCGCTT TGTGTGATCT
  301  AGTTATGCAT ACCAGGGCTT AATTAAAAAA GTCGGACTTG ATGTGGTCAA AAAGCTCAAT
  361  GCTGATGCGG TGGGGGATAG TATGCCCGAC TTTACCTTTA TTGTTGATTG TGACTTTGAG
  421  ACTGCTTTAA ACCGGATGGC CAAACGCGGT CAGGACAATT TATTGGACAA TACTGTTAAA
  481  AAGCAAGCGG ACTTTAATAC TATGCGCCAG TATTACCACA GTTTGGTTGA TAACAAACGC
  541  GTCTTTCTCT TAGACGGGCA AAACCAAACG GGTTGTCTGG AACAATTTAT TGAACAATTA
  601  AGCCAATGTT TAACCCAACC CACGCTCTCT TAA
Download Sequence
Operon 
OP2
Operon location 
2800 - 11960
Protein (mpn006)
Name 
Thymidylate kinase (EC 2.7.4.9) (dTMP kinase)
Stable ID 
Mpn006
Molecular Weight 
23100
Isoelectric Point 
7
Localization 
Cytoplasm
Comment Required for DNA replicacion, even in the presence of dNTPs. Different enzymes of the dNTPs metabolism interact funcionally or physically with the replication apparatus (J Bacteriol, 1996, 178:2804)
Sequence 
MKQGVFVAIEGVDGAGKTVLLEAFKQRFPQSFLGFKTLFSREPGGTPLAEKIRALLLHEAMEPLTEAYLFAASRTEHVRQ
LIQPALQQKQLVIVDRFVWSSYAYQGLIKKVGLDVVKKLNADAVGDSMPDFTFIVDCDFETALNRMAKRGQDNLLDNTVK
KQADFNTMRQYYHSLVDNKRVFLLDGQNQTGCLEQFIEQLSQCLTQPTLS
Post translational modifications
Modification Modified sequence Relative start Relative end Amino acid
Oxidation mKQGVFVAIEGVDGAGK 1 18 M
Oxidation QADFNTmR 162 170 M
GENE/PROTEIN tmk (Domains Overview)
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Domains (InterProScan)
Location (aa) Name (InterPro ID) Description GO terms Sequence Evalue
1-178 PTHR10344 (IPR018094) Thymidylate kinase Biological Process:
<'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0006233'>'dTDP' == '' ? '': 'dTDP'; 'biosynthetic' == '' ? '': 'biosynthetic'; 'process' == '' ? '': 'process'; ('GO' == '' ? '': 'GO';:0006233)

Molecular Function:
<'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0004798'>'thymidylate' == '' ? '': 'thymidylate'; 'kinase' == '' ? '': 'kinase'; 'activity' == '' ? '': 'activity'; ('GO' == '' ? '': 'GO';:0004798) <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0005524'>'ATP' == '' ? '': 'ATP'; 'binding' == '' ? '': 'binding'; ('GO' == '' ? '': 'GO';:0005524)

3.6e-28
1-188 SSF52540 (n.a.) NULL 9.3887e-44
1-197 TIGR00041 (IPR018094) Thymidylate kinase Biological Process:
<'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0006233'>'dTDP' == '' ? '': 'dTDP'; 'biosynthetic' == '' ? '': 'biosynthetic'; 'process' == '' ? '': 'process'; ('GO' == '' ? '': 'GO';:0006233)

Molecular Function:
<'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0004798'>'thymidylate' == '' ? '': 'thymidylate'; 'kinase' == '' ? '': 'kinase'; 'activity' == '' ? '': 'activity'; ('GO' == '' ? '': 'GO';:0004798) <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0005524'>'ATP' == '' ? '': 'ATP'; 'binding' == '' ? '': 'binding'; ('GO' == '' ? '': 'GO';:0005524)

0
3-200 G3DSA:3.40.50.300 (n.a.) NULL 0
9-197 PF02223 (IPR018094) Thymidylate kinase Biological Process:
<'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0006233'>'dTDP' == '' ? '': 'dTDP'; 'biosynthetic' == '' ? '': 'biosynthetic'; 'process' == '' ? '': 'process'; ('GO' == '' ? '': 'GO';:0006233)

Molecular Function:
<'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0004798'>'thymidylate' == '' ? '': 'thymidylate'; 'kinase' == '' ? '': 'kinase'; 'activity' == '' ? '': 'activity'; ('GO' == '' ? '': 'GO';:0004798) <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0005524'>'ATP' == '' ? '': 'ATP'; 'binding' == '' ? '': 'binding'; ('GO' == '' ? '': 'GO';:0005524)

0
93-105 PS01331 (IPR018095) Thymidylate kinase, conserved site Biological Process:
<'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0006233'>'dTDP' == '' ? '': 'dTDP'; 'biosynthetic' == '' ? '': 'biosynthetic'; 'process' == '' ? '': 'process'; ('GO' == '' ? '': 'GO';:0006233)

Molecular Function:
<'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0004798'>'thymidylate' == '' ? '': 'thymidylate'; 'kinase' == '' ? '': 'kinase'; 'activity' == '' ? '': 'activity'; ('GO' == '' ? '': 'GO';:0004798) <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0005524'>'ATP' == '' ? '': 'ATP'; 'binding' == '' ? '': 'binding'; ('GO' == '' ? '': 'GO';:0005524)

0
Protein Homology (BLASTP results)
Protein Start Protein End Hit Size Orthologous Organism Orthologous Start Orthologous End Evalue Identity Score Alignment
5 202 197 - MAG6850 Mycoplasma agalactiae 1 204 3e-26 30.1435 273
3 172 169 - Lactococcus lactis subsp. lactis KF147 2 165 0.000000004 28.9017 129
2 178 176 - MARTH_orf161 Mycoplasma arthritidis 3 182 3e-25 34.0541 264
1 150 149 - Caulobacter crescentus NA1000 1 151 7e-24 35.9477 257
5 148 143 - MCJ_003810 Mycoplasma conjunctivae 1 148 7e-25 35.8108 261
1 148 147 - MHO_0980 Mycoplasma hominis 1 152 1e-22 34.8684 241
3 176 173 - Lactococcus lactis subsp. lactis KF147 2 176 6e-25 36.5169 265
4 170 166 - Bacillus subtilis subsp. subtilis 3 169 7e-29 40.1163 303
4 170 166 - Bacillus subtilis subsp. subtilis 3 169 7e-29 40.1163 303
6 206 200 - b1098 Escherichia coli 5 206 4e-21 33.6449 234
1 208 207 - MG006 Mycoplasma genitalium 1 208 <1e-50 62.0192 715
5 186 181 - MCAP_0010 Mycoplasma capricolum subsp. capricolum 1 185 6e-32 38.9474 322
5 157 152 - MS53_0052 Mycoplasma synoviae 1 154 1e-26 36.7089 276
5 187 182 - MHP7448_0259 Mycoplasma hyopneumoniae 7448 1 188 5e-21 31.2169 227
5 206 201 - MMOB0760 Mycoplasma mobile 1 209 6e-32 35.545 321
5 186 181 - MSC_0046 Mycoplasma mycoides subsp. mycoides SC 1 185 4e-32 38.4211 324
2 200 198 - LIC_12814 Leptospira interrogans serovar Copenhage 4 200 0.0000000000005 29.3269 164
1 187 186 - MYCGA7210 Mycoplasma gallisepticum 4 189 2e-35 40.625 352
1 186 185 - MYPE8140 Mycoplasma penetrans 3 194 1e-28 35.4167 295
5 205 200 - Mycoplasma pulmonis 14 222 6e-26 33.1754 271
External IDs
COG 
COG0125F
EC number 
2.7.4.9
Gene ID 
877298
GI 
13507745
GO 
coenzyme metabolism
GO 
Nucleotide transport and metabolism
Home COG 
F
InterPro 
IPR000062|Thymidylate kinase
Old MP number 
MP148
Pathway 
Metabolism nucleotide
Pathway 
DNA replication
PDB homologs 
4tmk_A
PDB homologs 
1zin_
PDB homologs 
5tmp_A
PDB homologs 
1TMK-A
Pfam 
PF02223
PID 
g1673808
RefSeq 
NP_109694.1
Swiss-Prot protein ID 
KTHY_MYCPN
phylomeDB tree 
KTHY_MYCPN
UniProt 
P75106
Transcription
IMAGE BROWSERS

OPERON OP2 (Genomic Overview)
Region:2800-11960

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STRING image

STRING of Mpn006STRING legend

PDB image(s)

4tmk

PDB 4tmk

1zin

PDB 1zin

5tmp

PDB 5tmp

1TMK

PDB 1TMK
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