MyMpn Project

Gene pfk (MPN302)

Name	pfk
Stable ID	MPN302
Location	355685 - 356671 +
Sequence	1 ATGAGTCCAA AAACAACCAA AAAAATTGCC ATTTTAACCT CTGGTGGTGA TGCTCCAGGG 61 ATGAATGCCA CACTAGTTTA CCTAACGCGT TATGCCACTA GTTCTGAAAT TGAAGTTTTC 121 TTTGTGAAAA ACGGTTATTA TGGGCTGTAC CATGATGAGT TAGTACCCGC TCATCAATTA 181 GATTTGTCAA ACAGCTTGTT TAGTGCTGGC ACCGTGATTG GTAGTAAGCG CTTTGTCGAA 241 TTTAAGGAGT TAAAGGTCCG CGAGCAAGCA GCACAGAATC TTAAAAAGCG CCAAATCGAT 301 TACCTAGTGG TTATTGGTGG TGATGGTAGT TACATGGGCG CTAAATTGCT AAGCGAGTTG 361 GGCGTTAACT GTTACTGTTT GCCGGGTACG ATTGACAACG ACATAAATTC GAGTGAGTTT 421 ACAATTGGTT TTCTCACGGC TTTGGAGTCG ATTAAGGTCA ATGTCCAGGC CGTGTACCAC 481 ACTACGAAAT CACATGAACG GGTCGCCATT GTGGAGGTGA TGGGTCGCCA TTGTGGTGAT 541 TTAGCCATTT TTGGTGCCTT AGCCACCAAT GCTGACTTTG TGGTGACTCC TAGCAATAAA 601 ATGGATTTAA AGCAGCTAGA AAGTGCTGTC AAAAAGATCT TGCAACACCA AAACCACTGT 661 GTGGTGATTG TTAGTGAAAA CATCTATGGC TTTGATGGTT ATCCCTCACT TACAGCGATC 721 AAACAGCACT TTGATGCTAA CAACATGAAG TGTAACCTGG TGTCCTTGGG TCACACGCAA 781 CGCGGATTTG CCCCTACCAG CCTCGAGTTA GTCCAAATTA GTTTAATGGC GCAACACACG 841 ATTAACTTAA TTGGACAAAA CAAGGTTAAC CAGGTCATTG GTAATAAGGC CAATGTGCCC 901 GTTAACTATG ACTTTGATCA AGCCTTTAAC ATGCCACCGG TTGATCGCAG CGCTTTAATT 961 GCAGTCATTA ATAAAAATAT TATTTAA
Download Sequence
Operon	OP120
Operon location	355675 - 358180

Protein (mpn302)

Name	6-phosphofructokinase (Phosphofructokinase) (EC 2.7.1.11) (Phosphohexokinase)
Stable ID	Mpn302
Molecular Weight	36080
Isoelectric Point	8
Localization	Cytoplasm
Comment	-
Sequence	MSPKTTKKIAILTSGGDAPGMNATLVYLTRYATSSEIEVFFVKNGYYGLYHDELVPAHQLDLSNSLFSAGTVIGSKRFVE FKELKVREQAAQNLKKRQIDYLVVIGGDGSYMGAKLLSELGVNCYCLPGTIDNDINSSEFTIGFLTALESIKVNVQAVYH TTKSHERVAIVEVMGRHCGDLAIFGALATNADFVVTPSNKMDLKQLESAVKKILQHQNHCVVIVSENIYGFDGYPSLTAI KQHFDANNMKCNLVSLGHTQRGFAPTSLELVQISLMAQHTINLIGQNKVNQVIGNKANVPVNYDFDQAFNMPPVDRSALI AVINKNII

Post translational modifications

Modification	Modified sequence	Relative start	Relative end	Amino acid
Oxidation	KIAILTSGGDAPGmNATLVYLTR	8	31	M
Oxidation	IAILTSGGDAPGmNATLVYLTR	9	31	M
Oxidation	QIDYLVVIGGDGSYmGAK	98	116	M
Oxidation	VAIVEVmGR	168	177	M
Oxidation	VAIVEVmGr	168	177	M
Oxidation	ANVPVNYDFDQAFNmPPVDr	297	317	M
Oxidation	ANVPVNYDFDQAFNmPPVDR	297	317	M

GENE/PROTEIN pfk (Domains Overview)

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Domains (InterProScan)

Location (aa)	Name (InterPro ID)	Description	GO terms	Sequence	Evalue
3-219	G3DSA:3.40.50.450 (n.a.)	NULL			0
3-328	PIRSF000532 (IPR012003)	ATP-dependent phosphofructokinase, prokaryotic	Biological Process: <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0006002'>'fructose' == '' ? '': 'fructose'; 6-'phosphate' == '' ? '': 'phosphate'; 'metabolic' == '' ? '': 'metabolic'; 'process' == '' ? '': 'process'; ('GO' == '' ? '': 'GO';:0006002) <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0006096'>'glycolysis' == '' ? '': 'glycolysis'; ('GO' == '' ? '': 'GO';:0006096) Molecular Function: <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0005524'>'ATP' == '' ? '': 'ATP'; 'binding' == '' ? '': 'binding'; ('GO' == '' ? '': 'GO';:0005524) <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0008443'>'phosphofructokinase' == '' ? '': 'phosphofructokinase'; 'activity' == '' ? '': 'activity'; ('GO' == '' ? '': 'GO';:0008443)		0
7-284	PF00365 (IPR000023)	Phosphofructokinase domain	Biological Process: <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0006096'>'glycolysis' == '' ? '': 'glycolysis'; ('GO' == '' ? '': 'GO';:0006096) Cellular Component: <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0005945'>6-'phosphofructokinase' == '' ? '': 'phosphofructokinase'; 'complex' == '' ? '': 'complex'; ('GO' == '' ? '': 'GO';:0005945) Molecular Function: <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0003872'>6-'phosphofructokinase' == '' ? '': 'phosphofructokinase'; 'activity' == '' ? '': 'activity'; ('GO' == '' ? '': 'GO';:0003872)		0
7-310	SSF53784 (IPR000023)	Phosphofructokinase domain	Biological Process: <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0006096'>'glycolysis' == '' ? '': 'glycolysis'; ('GO' == '' ? '': 'GO';:0006096) Cellular Component: <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0005945'>6-'phosphofructokinase' == '' ? '': 'phosphofructokinase'; 'complex' == '' ? '': 'complex'; ('GO' == '' ? '': 'GO';:0005945) Molecular Function: <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0003872'>6-'phosphofructokinase' == '' ? '': 'phosphofructokinase'; 'activity' == '' ? '': 'activity'; ('GO' == '' ? '': 'GO';:0003872)		0
11-30	PR00476 (IPR022953)	Phosphofructokinase			0
36-49	PR00476 (IPR022953)	Phosphofructokinase			0
98-114	PR00476 (IPR022953)	Phosphofructokinase			0
122-266	PTHR13697 (n.a.)	NULL			1.3e-25
125-142	PR00476 (IPR022953)	Phosphofructokinase			0
143-161	PR00476 (IPR022953)	Phosphofructokinase			0
163-179	PR00476 (IPR022953)	Phosphofructokinase			0
181-198	PR00476 (IPR022953)	Phosphofructokinase			0
216-228	PR00476 (IPR022953)	Phosphofructokinase			0
248-270	PR00476 (IPR022953)	Phosphofructokinase			0

Protein Homology (BLASTP results)

Protein Start	Protein End	Hit Size	Orthologous	Organism	Orthologous Start	Orthologous End	Evalue	Identity	Score	Alignment
7	325	318	- MCJ_005670	Mycoplasma conjunctivae	3	318	<1e-50	37.0717	501
7	284	277	-	Lactococcus lactis subsp. lactis KF147	2	276	<1e-50	36.2007	472
7	305	298	-	Bacillus subtilis subsp. subtilis	2	296	<1e-50	36.6667	528
7	305	298	-	Bacillus subtilis subsp. subtilis	2	296	<1e-50	36.6667	528
7	310	303	- b3916	Escherichia coli	3	302	<1e-50	39.4137	581
8	328	320	- MG215	Mycoplasma genitalium	3	323	<1e-50	66.3551	1175
8	271	263	- Rv3010c	Mycobacterium tuberculosis	2	286	8e-34	32.526	346
7	320	313	- MCAP_0220	Mycoplasma capricolum subsp. capricolum	3	314	<1e-50	40.566	572
21	314	293	- MS53_0296	Mycoplasma synoviae	1	291	<1e-50	37.8378	504
6	325	319	- MHP7448_0111	Mycoplasma hyopneumoniae 7448	2	318	<1e-50	35.4037	505
7	325	318	- MMOB3200	Mycoplasma mobile	3	321	<1e-50	41.1765	570
7	320	313	- MSC_0260	Mycoplasma mycoides subsp. mycoides SC	40	351	<1e-50	40.566	565
10	226	216	- LIC_20088	Leptospira interrogans serovar Copenhage	71	298	0.000000000000001	28.8703	189
6	325	319	- MYCGA4800	Mycoplasma gallisepticum	5	327	<1e-50	46.7492	705
7	320	313	- MYPE5920	Mycoplasma penetrans	2	317	<1e-50	40.8805	606
7	319	312	-	Mycoplasma pulmonis	3	313	<1e-50	37.6997	537

External IDs

COG	COG0205G
EC number	2.7.1.11
Gene ID	877241
GI	13508041
GO	Carbohydrate transport and metabolism
Home COG	G
InterPro	IPR000023\|Phosphofructokinase
InterPro	IPR012003\|ATP-dependent phosphofructokinase, prokaryotic
Old MP number	MP534
Pathway	Metabolism energy
PDB homologs	6pfk_A
PDB homologs	3pfk_
PDB homologs	4pfk_
Pfam	PF00365
PID	g1674230
RefSeq	NP_109990.1
Swiss-Prot protein ID	K6PF_MYCPN
phylomeDB tree	K6PF_MYCPN
UniProt	P75476

Transcription

IMAGE BROWSERS

OPERON OP120 (Genomic Overview)

Region:355675-358180

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STRING image

STRING legend

PDB image(s)

PDB 6pfk

PDB 3pfk

PDB 4pfk