MyMpn Project

Gene acpS (MPN298)

Name	acpS
Stable ID	MPN298
Location	352387 - 352746 +
Sequence	1 ATGATTCTAG GCATAGGGAT TGATTTAGTC GAAATCAAAC GCTTTGAACA ATTAGCTAGA 61 CAAACTGATA ACTGTTTTGC GAAACGCTTG TTGACTTCAA CGGAGTACGC GCACTATGCG 121 AAGCTGCGTA AAGATAGTGA AAAGTCGAGT TTTTTAGCAG TCCACTGGTC ATTAAAGGAA 181 GCGATTTATA AGGCTGTTAA CCACATCAAG CCATTGTTTA GCCAACTGGA AATTACAAAG 241 AAAAACCAAC GTTATAACTG CCAGATTGAC CCTAAGATTG AACTTTTGCT CTCGGTTAGT 301 TACAGCAGTA ATAACATTAC TGCCATCTGT TTGGCACAAC AAACACCATG AAAAAATTAA
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Operon	OP119
Operon location	348825 - 355675

Protein (mpn298)

Name	Holo-[acyl-carrier-protein] synthase (Holo-ACP synthase) (EC 2.7.8.7) (4'-phosphopantetheinyl transferase acpS)
Stable ID	Mpn298
Molecular Weight	13090
Isoelectric Point	10
Localization	Cytoplasm
Comment	-
Sequence	MILGIGIDLVEIKRFEQLARQTDNCFAKRLLTSTEYAHYAKLRKDSEKSSFLAVHWSLKEAIYKAVNHIKPLFSQLEITK KNQRYNCQIDPKIELLLSVSYSSNNITAICLAQQTPWKN

Post translational modifications

No post translational modifications were found

GENE/PROTEIN acpS (Domains Overview)

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Domains (InterProScan)

Location (aa)	Name (InterPro ID)	Description	GO terms	Sequence	Evalue
1-114	SSF56214 (IPR008278)	4'-phosphopantetheinyl transferase	Biological Process: <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0009059'>'macromolecule' == '' ? '': 'macromolecule'; 'biosynthetic' == '' ? '': 'biosynthetic'; 'process' == '' ? '': 'process'; ('GO' == '' ? '': 'GO';:0009059) Molecular Function: <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0000287'>'magnesium' == '' ? '': 'magnesium'; 'ion' == '' ? '': 'ion'; 'binding' == '' ? '': 'binding'; ('GO' == '' ? '': 'GO';:0000287) <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0008897'>'holo' == '' ? '': 'holo';-['acyl' == '' ? '': 'acyl';-'carrier' == '' ? '': 'carrier';-'protein' == '' ? '': 'protein';] 'synthase' == '' ? '': 'synthase'; 'activity' == '' ? '': 'activity'; ('GO' == '' ? '': 'GO';:0008897)		1.3e-17
1-114	G3DSA:3.90.470.20 (n.a.)	NULL			1.1e-21
1-119	TIGR00556 (IPR004568)	Phosphopantethiene-protein transferase	Biological Process: <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0006633'>'fatty' == '' ? '': 'fatty'; 'acid' == '' ? '': 'acid'; 'biosynthetic' == '' ? '': 'biosynthetic'; 'process' == '' ? '': 'process'; ('GO' == '' ? '': 'GO';:0006633) Molecular Function: <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0000287'>'magnesium' == '' ? '': 'magnesium'; 'ion' == '' ? '': 'ion'; 'binding' == '' ? '': 'binding'; ('GO' == '' ? '': 'GO';:0000287) <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0008897'>'holo' == '' ? '': 'holo';-['acyl' == '' ? '': 'acyl';-'carrier' == '' ? '': 'carrier';-'protein' == '' ? '': 'protein';] 'synthase' == '' ? '': 'synthase'; 'activity' == '' ? '': 'activity'; ('GO' == '' ? '': 'GO';:0008897)		3.69999e-19
5-66	PF01648 (IPR008278)	4'-phosphopantetheinyl transferase	Biological Process: <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0009059'>'macromolecule' == '' ? '': 'macromolecule'; 'biosynthetic' == '' ? '': 'biosynthetic'; 'process' == '' ? '': 'process'; ('GO' == '' ? '': 'GO';:0009059) Molecular Function: <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0000287'>'magnesium' == '' ? '': 'magnesium'; 'ion' == '' ? '': 'ion'; 'binding' == '' ? '': 'binding'; ('GO' == '' ? '': 'GO';:0000287) <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0008897'>'holo' == '' ? '': 'holo';-['acyl' == '' ? '': 'acyl';-'carrier' == '' ? '': 'carrier';-'protein' == '' ? '': 'protein';] 'synthase' == '' ? '': 'synthase'; 'activity' == '' ? '': 'activity'; ('GO' == '' ? '': 'GO';:0008897)		0.0000000000034
8-67	PD004282 (IPR004568)	Phosphopantethiene-protein transferase	Biological Process: <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0006633'>'fatty' == '' ? '': 'fatty'; 'acid' == '' ? '': 'acid'; 'biosynthetic' == '' ? '': 'biosynthetic'; 'process' == '' ? '': 'process'; ('GO' == '' ? '': 'GO';:0006633) Molecular Function: <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0000287'>'magnesium' == '' ? '': 'magnesium'; 'ion' == '' ? '': 'ion'; 'binding' == '' ? '': 'binding'; ('GO' == '' ? '': 'GO';:0000287) <'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0008897'>'holo' == '' ? '': 'holo';-['acyl' == '' ? '': 'acyl';-'carrier' == '' ? '': 'carrier';-'protein' == '' ? '': 'protein';] 'synthase' == '' ? '': 'synthase'; 'activity' == '' ? '': 'activity'; ('GO' == '' ? '': 'GO';:0008897)		0

Protein Homology (BLASTP results)

Protein Start	Protein End	Hit Size	Orthologous	Organism	Orthologous Start	Orthologous End	Evalue	Identity	Score	Alignment
4	85	81	- MAG7230	Mycoplasma agalactiae	5	81	0.000000000002	39.0244	150
5	110	105	- MCJ_001220	Mycoplasma conjunctivae	2	105	0.000000000005	33.945	146
5	80	75	- MHO_0380	Mycoplasma hominis	2	71	0.000005	32.8947	94
1	65	64	-	Lactococcus lactis subsp. lactis KF147	1	64	0.0000005	33.8462	106
1	67	66	-	Bacillus subtilis subsp. subtilis	1	65	0.0000004	40.2985	111
1	67	66	-	Bacillus subtilis subsp. subtilis	1	65	0.0000009	40.2985	108
3	113	110	- MS53_0098	Mycoplasma synoviae	1	101	0.0000000006	29.7297	128
5	114	109	- MMOB4790	Mycoplasma mobile	7	101	0.0000000008	35.4545	127
1	113	112	- MSC_0578	Mycoplasma mycoides subsp. mycoides SC	1	106	0.000004	29.2035	96
1	114	113	- MYCGA4050	Mycoplasma gallisepticum	1	110	9e-20	42.1053	214
3	111	108	- MYPE350	Mycoplasma penetrans	14	117	0.00000000001	36.036	145
2	114	112	-	Mycoplasma pulmonis	3	100	0.000000005	33.6283	122
1	114	113	- MG211.1	Mycoplasma genitalium	1	112	1e-34	58.7719	341

External IDs

COG	COG0736I
EC number	2.7.8.7
Gene ID	877350
GI	13508037
GO	Lipid metabolism
Home COG	I
InterPro	IPR004568\|Phosphopantethiene-protein transferase
InterPro	IPR008278\|4'-phosphopantetheinyl transferase
Old MP number	MP538
Pathway	Metabolism�
PDB homologs	1fte_A
PDB homologs	1fth_A
PDB homologs	1ftf_A
Pfam	PF01648
PID	g1674234
RefSeq	NP_109986.1
Swiss-Prot protein ID	ACPS_MYCPN
phylomeDB tree	ACPS_MYCPN
UniProt	P75480

Transcription

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OPERON OP119 (Genomic Overview)

Region:348825-355675

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STRING image

STRING legend

PDB image(s)

PDB 1fte

PDB 1fth

PDB 1ftf