MyMpn Project

Name	pfpI
Stable ID	MPN294
Location	350397 - 351017 +
Sequence	1 ATGGATTTGC TTACAACCGC AAACAAAACG CCGCGAATCG CCAAATCACG TCCTGTTCGA 61 ATTGCCATCA TTATAACGCA GAAGACTAAT GATCTGCACG CTACTGTACC CTGCTTTTTA 121 TGGCGCAAAG CAAGGTATGC TGTTGACCTG ATTTCCGCTG AAGCCAAAGC TAGCATTATG 181 TTAGAGATGG GGATTCATGT GCGCTGTGAC AACACTTTGT CCAAAACTAA CTTTAACCAG 241 TATACCGCTG CTTTTATTCC CCATGGCAAC ACTACTAGGT TGGTGGAAAT AGACAAACTA 301 AGAAAGGACT TGGAGAAGTT TGTCTATAAA CCCAAGGGAC CAATGCGCTG GTTGTTTAGC 361 AGTGGTAATG GTGCTTGTGT TTTGAAGGAG TTTGACTTGA TTGCCCCTGA CCAATTAGTC 421 ACCGTTCAAA ACGAAAAGGA AATGGTTAAA CTTTTGGGAA AAAATTTCAT CAAGCAACCA 481 GTACATGTGG ACAAAAACAT TATTAGTTGT GCCAATTCTT GTGGCTTGAC TAAATTCTCC 541 TTTAAGGTAA TTGAAGAGCT TTCAGGAATA GAACTAGCGC GCAAAACGGC GAATCTTGTT 601 GACCATATCT ACAAAGGATA A
Download Sequence
Operon	OP119
Operon location	348825 - 355675

MDLLTTANKTPRIAKSRPVRIAIIITQKTNDLHATVPCFLWRKARYAVDLISAEAKASIMLEMGIHVRCDNTLSKTNFNQ

YTAAFIPHGNTTRLVEIDKLRKDLEKFVYKPKGPMRWLFSSGNGACVLKEFDLIAPDQLVTVQNEKEMVKLLGKNFIKQP

VHVDKNIISCANSCGLTKFSFKVIEELSGIELARKTANLVDHIYKG

Name	SImilar to intracellular protease ThiJ/PfpI;
Stable ID	Mpn294
Molecular Weight	22660
Isoelectric Point	10
Localization	Cytoplasm
Comment	Misses protease catalytic residues; members of this family are TFs; The pfpI-defective mutants in both PAO1 and PA14 showed higher spontaneous mutation rates than the wild-type strains, suggesting that PfpI plays a key role in DNA protection under nonstress conditions. Moreover, the inactivation of pfpI resulted in a dramatic increase in the H2O2-induced mutant frequency. Journal of Bacteriology, February 2009, p. 844-850, Vol. 191, No. 3
Sequence	MDLLTTANKTPRIAKSRPVRIAIIITQKTNDLHATVPCFLWRKARYAVDLISAEAKASIMLEMGIHVRCDNTLSKTNFNQ YTAAFIPHGNTTRLVEIDKLRKDLEKFVYKPKGPMRWLFSSGNGACVLKEFDLIAPDQLVTVQNEKEMVKLLGKNFIKQP VHVDKNIISCANSCGLTKFSFKVIEELSGIELARKTANLVDHIYKG

Protein Start	Protein End	Hit Size	Orthologous	Organism	Orthologous Start	Orthologous End	Evalue	Identity	Score	Alignment
20	180	160	-	Bacillus subtilis subsp. subtilis	4	161	0.00000002	24.2236	127
20	180	160	-	Bacillus subtilis subsp. subtilis	4	161	0.00000002	24.2236	127
20	191	171	- MCAP_0510	Mycoplasma capricolum subsp. capricolum	3	169	0.000005	23.1214	99
17	202	185	- MYCGA2110	Mycoplasma gallisepticum	7	191	1e-20	29.7872	225
15	198	183	- MYPE700	Mycoplasma penetrans	5	186	1e-20	28.1081	226

COG	COG0693R
EC number	3.1.-.-
Gene ID	877198
GI	13508033
GO	Post-translational modification, protein turnover, chaperones
Home COG	O
InterPro	IPR002818\|ThiJ/PfpI
Old MP number	MP541
Pathway	Protein degradation
PDB homologs	1pe0_A
PDB homologs	1j42_A
PDB homologs	1g2i_A
Pfam	PF01965
PID	g1674238
RefSeq	NP_109982.1
Swiss-Prot protein ID	Y294_MYCPN
phylomeDB tree	Y294_MYCPN
UniProt	P75483