MyMpn
The Mycoplasma pneumoniae database
 
e.g Mpn001 or dnaN or polymerase
Gene thiI (MPN550)
Name 
thiI
Stable ID 
MPN550
Location 
670253 - 671416 -
Sequence 
    1  ATGGGATTGC ATAATGAACC AAATACTATT CTAATCTGCC GTTATGGCGA ACTTGTTTTA
   61  AAGGGCAAGA ACCGCTTGCA GTTTGTCAAA CAACTCAAAA AGAACGTTAA ACAAGCCTTT
  121  AAGAAACTAA GCATTACTAA CCCAGTTGAC TACCAGTTTG ACATGTTGGT AGTGGGTGAA
  181  GTAATTTCCA CCCAAAGATC GTTATTAAAA AATCTCTTTA CCAGATTACC GGGTTTGAGT
  241  GTTTGCTTGT TTGCCTTACA AATCCCTCAT GATGAAGCGC AATTGTTAGC ACTGCTACAG
  301  CAAGTGGTAC AATCCCACCC ATCGTTCAAA ATTGAGGTAA GACGGCGTGA TAAATTATTT
  361  GCTTGCAATT CCAGTGCCTT CAAAAAGTAC CTAGCTTTAC AGTTATGGGA AAAATACCAA
  421  TTGAAGGGTA AGTTAGTTGA CCCTGCCATT ACGGTGCATG TCGAAGTAAC TAAGGAACAT
  481  TTCCTAATAA TTAGTGAAAG CTTTAATGGT ATTGGTGGTC TACCGGTCTT TACTAGTGGT
  541  ACTGCTTTGG CGTTACTGTC TGGTGGCATA GACAGTCCAG TAGCCGCTTC CCTAGTTTTA
  601  CAACGAGGTT TTAATGTTGA CTTTATTACT TTTATTAATG AGCCCGGACA TAACGCTGCC
  661  ACAATAGGCA AAATTCAACG GTTAGCTAAC TTAGTTTCCC TTAACCAAAC GCTTTGTACT
  721  GGGAGACTGT TTGTCTTTGA CTTTACCGAT TTACAGAAAG AGTTGAGTCA TATTAGTCTG
  781  GAAGGATACC GGATTGTTTT AATGCGCCGT TGCTTTTACA AGATTGCTAG TTTGTTTAAA
  841  TATGATTGTT TAATCACCGG GGAAGCATTG GGACAAGTAG CTTCACAAAC AATTGATAAT
  901  TTGAAGGTAA TCCAAGCTGT TGTGCCCAAT ACCTTTGTGA TTCGCCCGTT AATAGGCTTA
  961  AGTAAAGATA AAATAATTGA ATGAGCTAAG GCACTGGGTA CCTTTGAAAC TTCAATTGAG
 1021  CACCATATGG ATACCTGTAC TGTGTTTGCT CCCAAAAAAC CAACTACTAA GGCTAAGTTA
 1081  GCGATCGTTG AAAAGCTTGA GAGTGAACTT TTGTTTGTCC GTGAACTAAT TGAAGCTGGT
 1141  GTCAAGAAGC TGCAAAATGA TTAA
Download Sequence
Operon 
OP353
Operon location 
670575 - 677306
Protein (mpn550)
Name 
Probable thiamine biosynthesis protein thiI or tRNA sulfur transferase modification enzyme (EC 2.8.1.4)
Stable ID 
Mpn550
Molecular Weight 
42570
Isoelectric Point 
10
Localization 
Cytoplasm
Comment Also icsS; U->s4U (4-thiouridin)
Sequence 
MGLHNEPNTILICRYGELVLKGKNRLQFVKQLKKNVKQAFKKLSITNPVDYQFDMLVVGEVISTQRSLLKNLFTRLPGLS
VCLFALQIPHDEAQLLALLQQVVQSHPSFKIEVRRRDKLFACNSSAFKKYLALQLWEKYQLKGKLVDPAITVHVEVTKEH
FLIISESFNGIGGLPVFTSGTALALLSGGIDSPVAASLVLQRGFNVDFITFINEPGHNAATIGKIQRLANLVSLNQTLCT
GRLFVFDFTDLQKELSHISLEGYRIVLMRRCFYKIASLFKYDCLITGEALGQVASQTIDNLKVIQAVVPNTFVIRPLIGL
SKDKIIEWAKALGTFETSIEHHMDTCTVFAPKKPTTKAKLAIVEKLESELLFVRELIEAGVKKLQND
Post translational modifications
No post translational modifications were found
GENE/PROTEIN thiI (Domains Overview)
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Domains (InterProScan)
Location (aa) Name (InterPro ID) Description GO terms Sequence Evalue
8-175 SSF143437 (n.a.) NULL 3.59999e-40
11-378 TIGR00342 (IPR003720) Thiamine biosynthesis protein Biological Process:
<'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0009228'>'thiamin' == '' ? '': 'thiamin'; 'biosynthetic' == '' ? '': 'biosynthetic'; 'process' == '' ? '': 'process'; ('GO' == '' ? '': 'GO';:0009228)

Cellular Component:
<'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0005737'>'cytoplasm' == '' ? '': 'cytoplasm'; ('GO' == '' ? '': 'GO';:0005737)

Molecular Function:
<'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0003723'>'RNA' == '' ? '': 'RNA'; 'binding' == '' ? '': 'binding'; ('GO' == '' ? '': 'GO';:0003723)

0
67-167 PS51165 (IPR004114) THUMP 0
80-167 SM00981 (IPR004114) THUMP 0.000018
83-165 PF02926 (IPR004114) THUMP 0.0000000012
171-336 G3DSA:3.40.50.620 (IPR014729) Rossmann-like alpha/beta/alpha sandwich fold 0.0000000000000018
176-372 SSF52402 (n.a.) NULL 2.50001e-35
178-371 PF02568 (IPR020536) Thiamine biosynthesis protein, C-terminal Biological Process:
<'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0009228'>'thiamin' == '' ? '': 'thiamin'; 'biosynthetic' == '' ? '': 'biosynthetic'; 'process' == '' ? '': 'process'; ('GO' == '' ? '': 'GO';:0009228)

Cellular Component:
<'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0005737'>'cytoplasm' == '' ? '': 'cytoplasm'; ('GO' == '' ? '': 'GO';:0005737)

Molecular Function:
<'A' == '' ? '': 'A'; 'class' == '' ? '': 'class';=''result' == '' ? '': 'result';' 'target' == '' ? '': 'target';='_'blank' == '' ? '': 'blank';' 'href' == '' ? '': 'href';=''http' == '' ? '': 'http';://'amigo' == '' ? '': 'amigo';.'geneontology' == '' ? '': 'geneontology';.'org' == '' ? '': 'org';/'cgi' == '' ? '': 'cgi';-'bin' == '' ? '': 'bin';/'amigo' == '' ? '': 'amigo';/'term' == '' ? '': 'term';-'details' == '' ? '': 'details';.'cgi' == '' ? '': 'cgi';?'term' == '' ? '': 'term';='GO' == '' ? '': 'GO';:0003723'>'RNA' == '' ? '': 'RNA'; 'binding' == '' ? '': 'binding'; ('GO' == '' ? '': 'GO';:0003723)

0
Protein Homology (BLASTP results)
Protein Start Protein End Hit Size Orthologous Organism Orthologous Start Orthologous End Evalue Identity Score Alignment
11 378 367 - MAG1310 Mycoplasma agalactiae 5 365 <1e-50 33.8501 483
11 384 373 - MARTH_orf098 Mycoplasma arthritidis 5 373 2.94273e-44 30.8094 430
8 383 375 - MHO_4030 Mycoplasma hominis 4 378 <1e-50 32.3077 446
11 349 338 - Lactococcus lactis subsp. lactis KF147 8 350 8e-38 30.1994 379
11 379 368 - Bacillus subtilis subsp. subtilis 6 378 2e-36 28.9474 371
11 379 368 - Bacillus subtilis subsp. subtilis 6 378 2e-37 29.2105 379
1 387 386 - MG372 Mycoplasma genitalium 1 385 <1e-50 61.2403 1238
15 334 319 - b0423 Escherichia coli 8 333 6e-33 30.303 339
11 382 371 - MCAP_0239 Mycoplasma capricolum subsp. capricolum 4 379 1.4013e-45 34.1207 441
11 370 359 - MS53_0505 Mycoplasma synoviae 5 356 <1e-50 34.5205 484
8 370 362 - MMOB0710 Mycoplasma mobile 16 373 8.40779e-45 31.6354 435
11 382 371 - MSC_0280 Mycoplasma mycoides subsp. mycoides SC 4 379 <1e-50 34.6457 450
5 381 376 - MYCGA5000 Mycoplasma gallisepticum 2 380 <1e-50 35.6955 669
14 349 335 - MYPE5860 Mycoplasma penetrans 8 343 <1e-50 36.7052 545
11 349 338 - Mycoplasma pulmonis 6 340 9.80909e-45 32.6648 435
External IDs
Alias 
icsS
COG 
COG0301H
EC number 
2.7.4.16
Gene ID 
877210
GI 
13508289
GO 
Coenzyme metabolism
Home COG 
H
InterPro 
IPR004114|THUMP
InterPro 
IPR003720|Thiamine biosynthesis protein
Old MP number 
MP292
Pathway 
tRNA Metabolism
PDB homologs 
1NSY-A
PDB homologs 
1GPM-A
PDB homologs 
1gpm_A
PDB homologs 
1j1z_A
PDB homologs 
1j20_A
Pfam 
PF06508
Pfam 
PF03054
Pfam 
PF02568
Pfam 
PF02926
PID 
g1673963
RefSeq 
NP_110239.1
Swiss-Prot protein ID 
THII_MYCPN
phylomeDB tree 
THII_MYCPN
UniProt 
P75228
Transcription
IMAGE BROWSERS

OPERON OP353 (Genomic Overview)
Region:670575-677306

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STRING image

STRING of Mpn550STRING legend

PDB image(s)

1NSY

PDB 1NSY

1GPM

PDB 1GPM

1gpm

PDB 1gpm

1j1z

PDB 1j1z

1j20

PDB 1j20
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